Diffusion-weighted imaging of bone marrow: current status.

Abstract:

:Diffusion-weighted imaging allows for measurement of tissue microstructure and reflects the random motion of water protons. It provides a new method to study bone marrow and bone marrow alterations on the basis of altered water-proton mobility in various diseases. Different diffusion-weighted methods have proved to be capable of differentiating between benign edema and tumorous involvement of bone marrow. It is especially useful for the distinction of acute benign osteoporotic and malignant vertebral compression fractures. Diagnosis is based on the contrast to normal bone marrow. Hypo- or isointensity reflects acute benign collapse, whereas hyperintensity is indicative of the tumorous nature of a fracture. Apparent diffusion coefficients (ADC) are significantly lower in metastatic disease than in bone marrow edema. Furthermore, bone marrow cellularity can be estimated by ADC measurements. Diffusion-weighted imaging might be helpful for monitoring response to therapy in metastatic disease.

journal_name

Eur Radiol

journal_title

European radiology

authors

Baur A,Dietrich O,Reiser M

doi

10.1007/s00330-003-1873-0

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

1699-708

issue

7

eissn

0938-7994

issn

1432-1084

journal_volume

13

pub_type

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