Abstract:
OBJECTIVES:To compare extraocular muscles (EOMs) T2, post-contrast T1 (T1Gad) signal intensity ratios (SIRs) and normalized-apparent diffusion coefficient (n-ADC) values in patients with thyroid-associated orbitopathy (TAO) at different phases of activity and severity and correlate MRI modifications to clinical evolution during follow-up. METHODS:A total of 74 TAO patients were classified as active or inactive on the basis of the clinical activity score (CAS). Severity of EOM impairment was evaluated by assigning a functional score to each rectus. T2, T1Gad SIRs and n-ADC of EOMs were compared in patients with active inflammation, those with inactive disease and 26 healthy controls, and correlated with clinical scores. MRI parameter variation was correlated with clinical modifications during follow-up. RESULTS:All MRI parameters in TAO EOMs were significantly higher than in healthy subjects and correlated with muscle dysfunction and CAS. EOMs of active patients showed higher T2 and T1Gad SIRs than those with inactive disease. The T2 SIR and n-ADC of normally functioning TAO EOMs were higher than those of healthy controls. SIRs decreased in clinically improved and clinically stable EOMs after therapy. CONCLUSIONS:T2 SIR, T1Gad SIR and n-ADC are objective measures of activity and severity of EOMs in TAO patients. MRI shows clinically silent muscle involvement and modifications. KEY POINTS:• MRI and DWI measures are objective, quantitative parameters of TAO activity and severity • MRI and DWI measures significantly correlate with clinical scores in TAO patients • MRI and DWI can identify clinically silent inflammation of deep orbital structures • MRI and DWI can depict subclinical modifications during follow-up • MRI and DWI may aid clinicians in choosing the most appropriate treatment.
journal_name
Eur Radioljournal_title
European radiologyauthors
Politi LS,Godi C,Cammarata G,Ambrosi A,Iadanza A,Lanzi R,Falini A,Bianchi Marzoli Sdoi
10.1007/s00330-014-3103-3subject
Has Abstractpub_date
2014-05-01 00:00:00pages
1118-26issue
5eissn
0938-7994issn
1432-1084journal_volume
24pub_type
杂志文章abstract::The aim of this study was to assess the capability of a 3D isotropic MRI T2-weighted sequence (3D T2 ISO) in the depiction of changes of neurovascular bundles (NVBs) after bilateral nerve-sparing radical retropubic prostatectomy (RRP). Furthermore, our aim was also to introduce a new MRI classification score of the NV...
journal_title:European radiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00330-008-1102-y
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Transient elastography-based liver stiffness value (TE-LSV) has been investigated for assessing clinically significant portal hypertension (CSPH). The aetiology of CSPH is an important factor determining TE-LSV. There is insufficient evidence for selecting cut-off values. AIMS:This study performed a meta-an...
journal_title:European radiology
pub_type: 杂志文章,meta分析
doi:10.1007/s00330-018-5478-z
更新日期:2018-12-01 00:00:00
abstract::The prevalence of benign focal liver lesions (BFLL) is high both in the general population and in patients with known malignancies. The gray-scale ultrasound (US) technique is usually the first-line imaging modality used in the radiological workup of such lesions, but unfortunately it lacks specificity. Furthermore, D...
journal_title:European radiology
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abstract::Photodynamic therapy (PDT) is a well-investigated locoregional cancer treatment in which a systemically administered photosensitizer is activated locally by illuminating the diseased tissue with light of a suitable wavelength. PDT offers various treatment strategies in oncology, especially palliative ones. This articl...
journal_title:European radiology
pub_type: 杂志文章,评审
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journal_title:European radiology
pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章,评审
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journal_title:European radiology
pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:European radiology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2009-02-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
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更新日期:2005-02-01 00:00:00
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