Abstract:
:The purpose of this study was to evaluate the reproducibility of CT-volumetric tumour response assessment of pulmonary metastasis using variable volume change thresholds (VCT) and target lesions with response evaluation criteria in solid tumours (RECIST). Fifty consecutive patients with pulmonary metastases undergoing follow-up multislice CT under chemotherapy were assessed for response to chemotherapy with modifications to RECIST: (1) decreasing the percentual VCT for diagnosis of tumour response (range = 70%-20%), (2) reducing the number of target lesions (range = 1-5). Continuous and categorical observer agreements were tested by Bland and Altman and extended (kappa(e)) or non-weighted kappa (kappa) and correlated with percentual VCT to predict observer agreement. A total of 202 metastases were evaluated (average volume = 522.4 mm(3) +/- 902.4 mm(3)). General agreement on treatment response was very high (kappa(e) = 0.93-1), but was reduced with VCT < 35% (kappa(e) < 0.95). Kappa correlation with VCT values was strong (r=0.94-0.96; p< or =0.0002). Average confidence decreased significantly at VCT < 45% (p < 0.01) and agreement on stable disease at VCT < 35% (kappa(e) < 0.95; p < 0.01). Reduction of target lesions (n < 3; VCT = 35%) resulted in decreased reader confidence (for n = 1: kappa = 0.49; p < 0.05). Agreement for evaluation of treatment response was robust using VCT > or =35% and > or =3 metastases. This may translate into shortening of follow-up intervals or enable for response assessment with tumours displaying minimal volume change.
journal_name
Eur Radioljournal_title
European radiologyauthors
Marten K,Auer F,Schmidt S,Rummeny EJ,Engelke Cdoi
10.1007/s00330-007-0642-xsubject
Has Abstractpub_date
2007-10-01 00:00:00pages
2561-71issue
10eissn
0938-7994issn
1432-1084journal_volume
17pub_type
杂志文章abstract::With the advent of powerful gradient coil systems and high-resolution surface coils, magnetic resonance imaging (MRI) has recently extended its role in the staging of rectal cancer. MRI is superior to endorectal ultrasound, the most widely used staging modality in patients with rectal tumors, in that it visualizes not...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-006-0388-x
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:To demonstrate the non-inferiority of synthetic image (SI) mammography versus full-field digital mammography (FFDM) in breast tomosynthesis (DBT) examinations. METHODS:An observational, retrospective, single-centre, multireader blinded study was performed, using 2384 images to directly compare SI and FFDM ba...
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journal_title:European radiology
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更新日期:1997-01-01 00:00:00
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