Abstract:
:Photodynamic therapy (PDT) is a well-investigated locoregional cancer treatment in which a systemically administered photosensitizer is activated locally by illuminating the diseased tissue with light of a suitable wavelength. PDT offers various treatment strategies in oncology, especially palliative ones. This article focuses on the development and evaluation of interstitial PDT for the treatment of solid tumors, particularly liver tumors. The PDT is mostly used for superficial and endoluminal lesions like skin or bladder malignancies and also more frequently applied for the treatment of lung, esophageal, and head and neck cancer. With the help of specially designed application systems, PDT is now becoming a practicable option for solid lesions, including those in parenchymal organs such as the liver. After intravenous treatment with the photosensitizer followed by interstitial light activation, contrast-enhanced computed tomography shows the development of therapy-induced necrosis around the light-guiding device. With the use of multiple devices, ablation of liver tumors seems to be possible, and no severe side effects or toxicities related to the treatment are reported. PDT can become a clinically relevant adjunct in the locoregional therapy strategies.
journal_name
Eur Radioljournal_title
European radiologyauthors
Vogl TJ,Eichler K,Mack MG,Zangos S,Herzog C,Thalhammer A,Engelmann Kdoi
10.1007/s00330-004-2290-8subject
Has Abstractpub_date
2004-06-01 00:00:00pages
1063-73issue
6eissn
0938-7994issn
1432-1084journal_volume
14pub_type
杂志文章,评审abstract:OBJECTIVES:Time-resolved contrast-enhanced MR angiography (4D-MRA), which allows the simultaneous visualization of the vasculature and blood-flow dynamics, is widely used in clinical routine. In this study, the impact of two different contrast agent injection methods on 4D-MRA was examined in a controlled, standardized...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-5178-0
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:Hypoxia is associated with poor prognosis and treatment resistance in breast cancer. However, the temporally variant nature of hypoxia can complicate interpretation of imaging findings. We explored the relationship between hypoxia and vascular function in breast tumours through combined 18F-fluoromisonidazol...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07067-2
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the performance of a computer-aided algorithm for automated stenosis detection at coronary CT angiography (cCTA). METHODS:We investigated 59 patients (38 men, mean age 58 +/- 12 years) who underwent cCTA and quantitative coronary angiography (QCA). All cCTA data sets were analyzed using a softwar...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-009-1644-7
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVES:To assess the inhibitory effect of gadoxetate disodium on the transporter system using indocyanine green (ICG). MATERIALS AND METHODS:Groups of six female B6 Albino mice were injected with the test agent (0.62 mmol/kg gadoxetate disodium) or phosphate-buffered saline (control) 10 min before injection of ICG...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5403-5
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVES:We hypothesized that non-contrast-enhanced PETRA (pointwise encoding time reduction with radial acquisition) MR (magnetic resonance) sequencing could be an alternative to unenhanced computed tomography (CT) in assessing cystic fibrosis (CF) lung structural alterations, as well as compared agreements and conc...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4218-5
更新日期:2016-11-01 00:00:00
abstract::Iodinated X-ray contrast media are among the most frequently used pharmaceuticals for intravascular administration. Although the newer low osmolality, nonionic contrast media, are generally well tolerated, it is well known that they, like the ionic contrast media, give rise to immediate or delayed adverse reactions in...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s003300000543
更新日期:2000-01-01 00:00:00
abstract::The use of Power Doppler sonography in nodal diseases provides an improvement of early and noninvasive diagnosis of regional metastatic involvement. By using Power Doppler sonography it is possible to characterize lymph nodes as reactively enlarged, metastases, malignant lymphoma, tuberculosis and to study cervical cy...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300101111
更新日期:2002-07-01 00:00:00
abstract::This study addressed the use of 3D MR angiography with flip angles (FAs) linearly varying across the excitation volume in order to diminish spin saturation. The shape of the ramp profile was varied to optimize the method for different regions and pathological alterations. Radio frequency pulses with ramp-shaped excita...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/BF00182478
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:To prospectively evaluate non-contrast-enhanced 7-Tesla (T) MRA for delineation of unruptured intracranial aneurysms (UIAs) in comparison with DSA. MATERIAL AND METHODS:Forty patients with single or multiple UIAs were enrolled in this IRB-approved trial. Sequences acquired at 7 T were TOF MRA and non-contrast-...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4323-5
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:In the vast majority of the laboratory-confirmed coronavirus disease 2019 (COVID-19) patients, computed tomography (CT) examinations yield a typical pattern and the sensitivity of this modality has been reported to be 97% in a large-scale study. Structured reporting systems simplify the interpretation and re...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06863-0
更新日期:2020-09-01 00:00:00
abstract::Spontaneous and isolated dissection of the superior mesenteric artery is a rare and often fatal event which has been successfully treated by surgery in several reported cases. We present a patient with acute mesenteric ischemia due to superior mesenteric artery dissection who was successfully treated by percutaneous e...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300000520
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:To determine the feasibility of MRI texture analysis as a method of quantifying subchondral bone architecture in knee osteoarthritis (OA). METHODS:Asymptomatic subjects aged 20-30 (group 1, n = 10), symptomatic patients aged 40-50 (group 2, n = 10) and patients scheduled for knee replacement aged 55-85 (gro...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-4142-0
更新日期:2016-09-01 00:00:00
abstract::The purpose was to assess changes in lactate content and other brain metabolites under visual stimulation in optical chiasm, optic radiations and occipital cortex using multiple voxel MR spectroscopy (MRS). 1H chemical shift imaging (CSI) examinations of transverse planes centered to include the above structures were ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-004-2494-y
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:We describe 64 foetuses with cortical formation abnormalities (CFA) who had two in utero magnetic resonance (iuMR) exams, paying particular detail to those in which the original classification of CFA category changed between the two studies. The goal was to attempt to quantify the value of third-trimester fo...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07125-9
更新日期:2020-09-04 00:00:00
abstract::The aim of this study was to assess the costs and effectiveness of selective short magnetic resonance imaging (MRI) in patients with acute knee injury. A model was developed to evaluate the selective use of MRI in patients with acute knee injury and no fracture on radiography based on the results of a trial in which 2...
journal_title:European radiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00330-008-1162-z
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVES:Vertebral augmentation (VA) has become routinely used in vertebral compression fractures (VCFs). VCFs are often associated with posterior wall protrusions (PWPs), which theoretically contraindicates vertebroplasty due to a higher risk of neurological complications. The latest generation of VA devices uses in...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06889-4
更新日期:2020-10-01 00:00:00
abstract::The aim of this study was to propose a quantitative MR protocol with very short acquisition time and good reliability in volume construction, for the evaluation of body composition in patients affected by Duchenne muscular dystrophy (DMD). This MR protocol was compared with common anthropometric evaluations of the sam...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-002-1392-4
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVES:To investigate image quality of triple-rule-out (TRO) computed tomography (CT) using a 320-row-detector CT system with substantially reduced contrast medium volume at 100 kV. METHODS:Forty-six consecutive patients with noncritical, acute chest pain underwent 320-row-detector CT using a two-step TRO protocol...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-011-2088-4
更新日期:2011-07-01 00:00:00
abstract::Management of trauma patients relies on a simple but obvious concept: Time is life! This is a challenge to the emergency radiologist in his evaluation of the radiological admission survey of severe trauma patients, since the latter need a quick and thorough survey of craniocerebral, cervical, thoracic, abdominal, and ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-002-1385-3
更新日期:2002-05-01 00:00:00
abstract::Although spatial resolution of current MR angiography is excellent, temporal resolution has remained unsatisfactory. We evaluated clinical applicability of 2D thick-slice, contrast-enhanced subtraction MR angiography (2D-MR digital subtraction angiography) with sub-second temporal resolution in cerebrovascular occlusi...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300000584
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To compare the sensitivity, specificity, and diagnostic accuracy of fat-only datasets reconstructed using a two-point Dixon technique, with corresponding opposed-phase (OP) and in-phase (IP) datasets for characterization of adrenal lesions at 3 Tesla (T). METHODS:Fifty-nine patients (21 male, 38 female) with...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-011-2244-x
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Fetal postmortem MR Imaging (pmMRI) has been recently used as an adjuvant tool to conventional brain autopsy after termination of pregnancy (TOP). Our purpose was to compare the diagnostic performance of intrauterine MRI (iuMRI) and pmMRI in the detection of brain anomalies in fetuses at early ge...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5878-0
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVES:Coronary artery volume indexed to left myocardial mass (CAVi), derived from coronary computed tomography angiography (CCTA), has been proposed as an indicator of diffuse atherosclerosis. We investigated the association of CAVi with quantitative flow parameters and its ability to predict ischemia as derived f...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07586-y
更新日期:2021-01-16 00:00:00
abstract:OBJECTIVE:Determination of coronary artery calcium scoring (CACS) in non-contrast computed tomography (CT) images has been shown to be an important prognostic factor in coronary artery disease (CAD). The objective of this study was to evaluate the accuracy of CACS from virtual non-contrast (VNC) imaging generated from ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07677-w
更新日期:2021-01-20 00:00:00
abstract:OBJECTIVE:To investigate comparative effectiveness of drug-eluting bead transarterial chemoembolization (DEB-TACE) versus Yttrium-90 (90Y)-radioembolization for hepatocellular carcinoma (HCC). METHODS:Studies comparing conventional (c)TACE versus 90Y-radioembolization or DEB-TACE for HCC treatment were identified usin...
journal_title:European radiology
pub_type: 杂志文章,meta分析
doi:10.1007/s00330-016-4548-3
更新日期:2017-05-01 00:00:00
abstract::Heterotropic mesenteric ossification is a rare entity. Only a few cases have been described in the literature. We report a case of heterotropic mesenteric ossification in a patient who underwent several laparotomies, after suffering from multiple gunshot wounds. We discuss the radiographic findings of this disease tha...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-004-2464-4
更新日期:2005-01-01 00:00:00
abstract::We evaluated an algorithm for automatic selection of the cardiac phase with the least motion for image reconstruction at coronary computed tomography (CT) angiography (CCTA). We analyzed data of 100 patients (49 female, mean age 59 years) who had undergone retrospectively ECG-gated CCTA. Two experienced observers visu...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-009-1368-8
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVES:Left ventricular mass (LVM) at cardiac magnetic resonance imaging (CMR) is a frequent end point in clinical trials in nephrology. Trial participants with end stage renal disease (ESRD) may have a greater frequency of incidental findings (IF). We retrospectively investigated prevalence of IF in previous resea...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4288-4
更新日期:2017-01-01 00:00:00
abstract::We report a rare case of primary thoracic rhabdomyosarcoma in a girl who was referred with acute chest pain, hacking cough, and wheezing. A chest X-ray revealed a complete opacity of the right hemithorax. Ultrasound revealed a right-sided pleural effusion and a solid mass above the liver dome, suggesting a neoplastic ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300000507
更新日期:2001-01-01 00:00:00
abstract::Meningeal hemangiopericytoma (MHP) is extremely rare in childhood. Mean age at diagnosis is between 38 and 43 years. We present an 8-year-old boy with MHP of the middle cranial fossa. Imaging findings were indistinguishable from an aggressive bone tumor such as Ewing's sarcoma. Imaging findings are presented and discu...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003309900222
更新日期:2000-01-01 00:00:00