Abstract:
OBJECTIVES:To assess the prognostic value of pre-therapeutic computed tomography (CT) attenuation of liver metastases for overall survival (OS) in metastatic colorectal cancer (mCRC). METHODS:In the open-label, randomised, prospective phase-III FIRE-3 trial, patients with histologically confirmed mCRC received fluorouracil (5-FU), leucovorin and irinotecan (FOLFIRI) with either cetuximab or bevacizumab. Participating patients gave written informed consent prior to study entry. In CT at baseline (portal venous phase, slice thickness ≤5 mm), mean attenuation [Hounsfield units (HU)] of liver metastases was retrospectively assessed by semi-automated volumetry. Its prognostic influence on OS was analysed in Kaplan-Meier-analysis and Cox proportional hazard regression and an optimal threshold was determined. RESULTS:In FIRE-3, 592 patients were enrolled between 2007 and 2012. Among the 347 patients eligible for liver volumetry, median baseline CT attenuation of liver metastases was 59.67 HU [interquartile range (IQR), 49.13, 68.85]. Increased attenuation was associated with longer OS {per 10 HU: hazard ratio (HR), 0.85 [95% confidence interval (CI), 0.78, 0.93], p < 0.001}. The optimised threshold (≥61.62 HU) was a strong predictor for increased OS [median, 21.3 vs 30.6 months; HR, 0.61 (95% CI, 0.47, 0.80), p < 0.001]. Multivariate regression controlling for correlated and further prognostic factors confirmed this [HR, 0.60 (95% CI, 0.45, 0.81), p = 0.001]. Furthermore, mean attenuation ≥61.62 HU was significantly associated with increased early tumour shrinkage (p = 0.002) and increased depth of response (p = 0.012). CONCLUSIONS:Increased mean baseline CT attenuation of liver metastases may identify mCRC patients with prolonged OS and better tumour response. KEY POINTS:• In colorectal cancer, increased attenuation of liver metastases in baseline computed tomography is a prognostic factor for prolonged OS (p < 0.001). • A threshold of ≥61.62 HU was determined as optimal cut-off to identify patients with prolonged OS (p < 0.001), early tumour shrinkage (p = 0.002) and increased depth of response (p = 0.012).
journal_name
Eur Radioljournal_title
European radiologyauthors
Froelich MF,Heinemann V,Sommer WH,Holch JW,Schoeppe F,Hesse N,Baumann AB,Kunz WG,Reiser MF,Ricke J,D'Anastasi M,Stintzing S,Modest DP,Kazmierczak PM,Hofmann FOdoi
10.1007/s00330-018-5454-7subject
Has Abstractpub_date
2018-12-01 00:00:00pages
5284-5292issue
12eissn
0938-7994issn
1432-1084pii
10.1007/s00330-018-5454-7journal_volume
28pub_type
杂志文章,多中心研究,随机对照试验abstract:OBJECTIVES:To analyse the diagnostic accuracy and to establish a predictive score based on diffusion-weighted magnetic resonance imaging (DWMRI) compared to exploratory laparotomy (EL) for predicting suboptimal cytoreductive surgery for different intra-abdominal sites of implants in patients with ovarian cancer. METHO...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-2837-7
更新日期:2013-09-01 00:00:00
abstract::We report a case of a 22-year-old male with Hunter syndrome who developed progressive major airway obstruction and was treated with insertion of plastic and metallic stents, with dramatic improvement in the patient's symptomatic and functional status. To the best of our knowledge, this is the first reported case of en...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300100932
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVES:To investigate the added diagnostic value of arterial spin labelling (ASL) and diffusion tensor imaging (DTI) to structural MRI for computer-aided classification of Alzheimer's disease (AD), frontotemporal dementia (FTD), and controls. METHODS:This retrospective study used MRI data from 24 early-onset AD an...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4691-x
更新日期:2017-08-01 00:00:00
abstract::To prove the usefulness of a simple laser marker system (LMS) in target definition as well as examination procedure for CT-guided interventions, 130 cases of diagnostic biopsies and lumbal sympathectomies were compared. In 75 cases LMS and in 55 cases a simple crossgrid was used. Taking advantage of the LMS, the param...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300051054
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:To compare contrast effects of gadobutrol with gadoterate meglumine for brain MRI in multiple sclerosis (MS) in a multicentre, randomized, prospective, intraindividual study at 3 T. METHODS:Institutional review board approval was obtained. Patients with known or suspected active MS lesions were included. Tw...
journal_title:European radiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00330-015-3889-7
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVES:Our aim was to investigate regional difference in brain activities in response to antiepileptic drug (AED) medications in benign epilepsy with central-temporal spikes (BECTS) using resting-state functional magnetic resonance imaging (fMRI). METHODS:Fifty-seven patients with BECTS underwent resting-state fMR...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4531-z
更新日期:2017-05-01 00:00:00
abstract::The objective of this study was to compare screen-film mammography (SFM) to full-field digital mammography (FFDM) regarding image quality as well as detectability and characterization of lesions using equivalent images of the same patient acquired with both systems. Two mammography units were used, one with a screen-f...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-001-1269-y
更新日期:2002-07-01 00:00:00
abstract::The purpose of the study was to evaluate a semiautomatic analysis tool for assessing global left ventricular myocardial function with multislice computed tomography (MSCT). We examined 33 patients with MSCT using 16x0.5 mm detector collimation and magnetic resonance imaging (MRI) on a 1.5-T scanner. MSCT data were ana...
journal_title:European radiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00330-005-2817-7
更新日期:2006-01-01 00:00:00
abstract::We report an uncommon case of spontaneous massive hemorrhage of the abdominal wall caused by rupture of a deep iliac circumflex (DIC) artery. Enhanced computed tomography (CT) demonstrated a marked extravasation in a huge hematoma of the abdominal wall. Although a pelvic arteriogram demonstrated no extravasation, a su...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050432
更新日期:1998-01-01 00:00:00
abstract::The performance of breath-hold MR imaging using two T2-weighted hybrid sequences (TSE, TGSE), two T2-weighted single-shot sequences (HASTE, EPI-SE), and one T1-weighted gradient-echo sequence (FLASH) was compared with a standard conventional T2-weighted SE sequence in 20 patients with focal liver lesions. Liver signal...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/BF00240685
更新日期:1996-01-01 00:00:00
abstract::The original version of this article, published on 19 August 2016, unfortunately contained a mistake. ...
journal_title:European radiology
pub_type: 已发布勘误
doi:10.1007/s00330-020-06947-x
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVES:To review the role of imaging in the diagnosis of recurrent disease in previously treated non-small cell lung cancer (NSCLC) and discuss the imaging pitfalls. METHODS:A comprehensive review of published literature on CT and PET imaging of NSCLC recurrence was performed. Diagnostic and prognostic values are ...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-011-2299-8
更新日期:2012-03-01 00:00:00
abstract::Carcinoid heart disease is a frequent complication of the carcinoid syndrome, usually presenting as right-sided valvular heart disease. Although the diagnosis is most often made with cardiac ultrasound, MRI and CT are valuable techniques for diagnosing carcinoid heart disease. ...
journal_title:European radiology
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVES:To validate new diagnostic criteria for hepatocellular carcinoma (HCC) on gadoxetic acid-enhanced MR imaging (Gd-EOB-MRI) using hypointensity on the hepatobiliary phase (HBP) as an alternative to washout in combination with ancillary features. METHODS:This retrospective study included 288 patients at high r...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5727-1
更新日期:2019-04-01 00:00:00
abstract::To investigate the influence of age, sex and spinal level on perfusion parameters of normal lumbar bone marrow with dynamic contrast-enhanced MRI (DCE MRI). Sixty-seven subjects referred for evaluation of low back pain or sciatica underwent DCE MRI of the lumbar spine. After subtraction of dynamic images, a region of ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-008-0943-8
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between paraspinal and psoas muscle volumes and acute osteoporotic or low-bone-mass compression fractures of the lumbar spine in postmenopausal women. METHODS:Patient data were retrieved retrospectively for postmenopausal women with L-spine magnetic resonance imaging (MRI) and...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-019-06034-w
更新日期:2019-09-01 00:00:00
abstract:INTRODUCTION:Numerous publications have studied the regional anatomy of the carpal tunnel to define a "safe zone" to reduce the risk of perioperative neurovascular complications. This zone, located between the ulnar neurovascular bundle and the median nerve, is considered to be safe mainly because of the absence of vas...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-019-06416-0
更新日期:2020-02-01 00:00:00
abstract::Developmental symptomatic C1 canal stenosis is very rare. We describe the computed tomography (CT) and magnetic resonance imaging (MRI) appearances in a 8-year-old child who presented with progressive upper and lower limb neurological symptoms and in whom imaging revealed the medial posterior hemiarches of a bifid C1 ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300000755
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To investigate the prevalence and diagnostic value of first-pass myocardial perfusion defects (PD) visualised by contrast-enhanced multidetector computed tomography (MDCT) in patients admitted for a first acute coronary syndrome (ACS). METHODS:Thirty-eight patients with non-ST segment elevation myocardial in...
journal_title:European radiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00330-010-1725-7
更新日期:2010-07-01 00:00:00
abstract::The aim of this study was to compare our computer-aided report writing system to standard techniques. A computer-aided reporting system for reporting on chest X-rays was developed and linked with a UNIX-based radiology information system. The reporting system consists of different text modules which can be composed to...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050505
更新日期:1998-01-01 00:00:00
abstract::Cardiovascular intervention, using MRI guidance, is challenging for clinical applications. Real-time imaging sequences with high spatial resolution are needed for monitoring intramyocardial delivery of drug, gene, or stem cell therapies. New generation MR scanners make local intramyocardial and vascular wall therapies...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-004-2622-8
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVES:To compare image quality and radiation dose of abdominal split-filter dual-energy CT (SF-DECT) combined with monoenergetic imaging to single-energy CT (SECT) with automatic tube voltage selection (ATVS). METHODS:Two-hundred single-source abdominal CT scans were performed as SECT with ATVS (n = 100) and SF-D...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5338-x
更新日期:2018-08-01 00:00:00
abstract::The imaging findings that ultrasonographically differentiate focal acute pancreatitis (FAP) from a malignant lesion of the pancreas are described. Focal acute pancreatitis is ultrasonographically (US) characterized as a hypoechoic, homogeneous, localized, subsegmental, non-expansive and diffusely demarcated lesion loc...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050756
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To update quality standards for CT colonography based on consensus among opinion leaders within the European Society of Gastrointestinal and Abdominal Radiology (ESGAR). MATERIAL AND METHODS:A multinational European panel of nine members of the ESGAR CT colonography Working Group (representing six EU countri...
journal_title:European radiology
pub_type: 杂志文章,实务指引
doi:10.1007/s00330-012-2632-x
更新日期:2013-03-01 00:00:00
abstract::The aim of the study was differential evaluation of new and classical sonographic features of benign thyroid nodules and thyroid cancer with three-dimensional gray-scale sonography and evaluation of the effectiveness of the thin-slice surface rendered images in comparison with multiplanar reformation (MPR) presentatio...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-005-2903-x
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVES:X-ray iodinated contrast media have been shown to generate contrast in MR images when used with the chemical exchange saturation transfer (CEST) approach. The aim of this study is to compare contrast enhancement (CE) capabilities and perfusion estimates between radiographic molecules and a Gd-based contrast ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4552-7
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to compare the diagnostic performance of direct C-arm flat panel computed tomography arthrography (FPCT-A) with direct magnetic resonance arthrography (MR-A) of the wrist in patients with clinically suspected pathologies. METHODS:Forty-nine patients underwent tri-compartmenta...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5901-5
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVES:To compare the significance of the two-compartment model, considering diffusional anisotropy with conventional diffusion analyzing methods regarding the detection of occult changes in normal-appearing white matter (NAWM) of multiple sclerosis (MS). METHODS:Diffusion-weighted images (nine b-values with six d...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3572-4
更新日期:2015-06-01 00:00:00
abstract::The aim of this study was to assess the correlation between 18F-fluorodeoxyglucose positron emission tomography (FDG PET) positivity of tumor recurrence and vascularity, Ki-67, p53, and histologic grade in patients with ovarian cancer. Nineteen patients with recurrent ovarian cancer underwent FDG PET before second-loo...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-006-0326-y
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVES:To evaluate the diffusion characteristics of inflammatory renal lesions and assess whether apparent diffusion coefficient (ADC) values can distinguish them from renal-cell carcinomas (RCCs). METHODS:Eighty-eight patients underwent multidetector computed tomography (MDCT), magnetic resonance imaging (MRI) an...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2577-0
更新日期:2013-01-01 00:00:00