Abstract:
OBJECTIVES:To investigate the added diagnostic value of arterial spin labelling (ASL) and diffusion tensor imaging (DTI) to structural MRI for computer-aided classification of Alzheimer's disease (AD), frontotemporal dementia (FTD), and controls. METHODS:This retrospective study used MRI data from 24 early-onset AD and 33 early-onset FTD patients and 34 controls (CN). Classification was based on voxel-wise feature maps derived from structural MRI, ASL, and DTI. Support vector machines (SVMs) were trained to classify AD versus CN (AD-CN), FTD-CN, AD-FTD, and AD-FTD-CN (multi-class). Classification performance was assessed by the area under the receiver-operating-characteristic curve (AUC) and accuracy. Using SVM significance maps, we analysed contributions of brain regions. RESULTS:Combining ASL and DTI with structural MRI resulted in higher classification performance for differential diagnosis of AD and FTD (AUC = 84%; p = 0.05) than using structural MRI by itself (AUC = 72%). The performance of ASL and DTI themselves did not improve over structural MRI. The classifications were driven by different brain regions for ASL and DTI than for structural MRI, suggesting complementary information. CONCLUSIONS:ASL and DTI are promising additions to structural MRI for classification of early-onset AD, early-onset FTD, and controls, and may improve the computer-aided differential diagnosis on a single-subject level. KEY POINTS:• Multiparametric MRI is promising for computer-aided diagnosis of early-onset AD and FTD. • Diagnosis is driven by different brain regions when using different MRI methods. • Combining structural MRI, ASL, and DTI may improve differential diagnosis of dementia.
journal_name
Eur Radioljournal_title
European radiologyauthors
Bron EE,Smits M,Papma JM,Steketee RME,Meijboom R,de Groot M,van Swieten JC,Niessen WJ,Klein Sdoi
10.1007/s00330-016-4691-xsubject
Has Abstractpub_date
2017-08-01 00:00:00pages
3372-3382issue
8eissn
0938-7994issn
1432-1084pii
10.1007/s00330-016-4691-xjournal_volume
27pub_type
杂志文章abstract:OBJECTIVES:To evaluate the changes in arterial oxygenation after portal decompression in Budd-Chiari syndrome (BCS) patients with hepatopulmonary syndrome (HPS). METHODS:From June 2014 to June 2015, all patients with BCS who underwent balloon angioplasty or transjugular intrahepatic portosystemic shunt (TIPS) creation...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5840-1
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVES:To investigate the value of diffusion tensor imaging (DTI) of articular cartilage to differentiate healthy from osteoarthritis (OA) subjects in all cartilage regions. METHODS:DTI was acquired sagittally at 7 T in ten healthy and five OA (Kellgren-Lawrence grade 2) subjects with a line scan diffusion tensor ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3155-4
更新日期:2014-07-01 00:00:00
abstract::This paper evaluates the management of 31 patients with bile leaks identified over a 7-year period. Leaks complicated cholecystectomy in 19 patients (11 laparoscopic, 8 open), interventional procedures in 10 (including surgery in 1), trauma in one and was spontaneous in one case. Confirmation of the diagnosis typicall...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050595
更新日期:1998-01-01 00:00:00
abstract::CT-guided procedures remain an important tool for diagnosis and tissue acquisition for primary diagnosis and molecular/tissue correlation. New imaging devices such as MDCT and PET/CT will improve diagnosis but percutaneous procedures will be needed to confirm and support new molecular and DNA treatments. Coagulopathic...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s10406-005-0130-9
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVES:Coronary artery volume indexed to left myocardial mass (CAVi), derived from coronary computed tomography angiography (CCTA), has been proposed as an indicator of diffuse atherosclerosis. We investigated the association of CAVi with quantitative flow parameters and its ability to predict ischemia as derived f...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07586-y
更新日期:2021-01-16 00:00:00
abstract::Magnetic resonance imaging can be used to measure the muscle volume of a given muscle or muscle group. The purpose of this study was to determine both the intra- and inter-observer variation of the manually outlined volume of the extensor muscles (tibialis anterior, extensor digitorum longus and extensor hallucis long...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-002-1334-1
更新日期:2002-12-01 00:00:00
abstract::We report a case of a large renal tumour containing small amounts of fat and some calcification that proved to be a renal cell carcinoma. The CT appearance of the tumour was suggestive of an angiomyolipoma. Although the overwhelming majority of renal masses containing fat are angiomyolipomas, in the presence of calcif...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050367
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:To compare the value of functional future liver remnant (functFLR) to established clinical and imaging variables in prediction of post-hepatectomy liver failure (PHLF) after major liver resection. METHODS:This retrospective, cross-sectional study included 62 patients, who underwent gadoxetic acid enhanced M...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5487-y
更新日期:2018-11-01 00:00:00
abstract::The purpose of this study was to assess the prevalence of lung cancer in a high-risk asbestos-exposed cohort using low-dose MDCT. Of a population of 5,389 former power-plant workers, 316 were characterized as individuals at highest risk for lung cancer according to a lung-cancer risk model including age, asbestos expo...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-006-0426-8
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:To assess the role of colour Doppler flow imaging (CDFI) in the diagnosis and management of lacrimal fossa lesions. METHODS:Institutional ethical committee approval was obtained. Fifty-one patients with 62 lacrimal fossa lesions were retrospectively included from 2003-2015. All patients underwent conventiona...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4438-8
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:To compare cardiac MRI with right heart catheterisation in patients with pulmonary hypertension (PH) and to evaluate its ability to assess PH severity. MATERIALS AND METHODS:Forty patients were included. MRI included cine and phase-contrast sequences, study of ventricular function, cardiac cavity areas and r...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-009-1664-3
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVES:To evaluate tomosynthesis compared with 2D-mammography in cancer detection and recalls in a screening-programme, and assess performing synthesized instead of 2D, and compare double reading of 2D with single reading of tomosynthesis. METHODS:Women (age 50-69 years) participating in the screening-programme we...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-5219-8
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVES:Comparison of bolus tracking with a fixed threshold versus a manual fast start for coronary CT angiography. METHODS:We retrospectively analysed 320-row coronary CT angiography of 50 patients with suspected or known coronary artery disease. Twenty-five examinations were initiated by a bolus tracking method (...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3148-3
更新日期:2014-06-01 00:00:00
abstract::Although spatial resolution of current MR angiography is excellent, temporal resolution has remained unsatisfactory. We evaluated clinical applicability of 2D thick-slice, contrast-enhanced subtraction MR angiography (2D-MR digital subtraction angiography) with sub-second temporal resolution in cerebrovascular occlusi...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300000584
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:Duchenne muscular dystrophy (DMD) is the most common and severe dystrophinopathy. DMD carriers rarely present with clinical symptoms, but may suffer from cardiac involvement. Because echocardiographic findings are inconsistent and cardiac magnetic resonance imaging (CMRI) data are limited, this study sought ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-3694-3
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To compare the sensitivity, specificity, and diagnostic accuracy of fat-only datasets reconstructed using a two-point Dixon technique, with corresponding opposed-phase (OP) and in-phase (IP) datasets for characterization of adrenal lesions at 3 Tesla (T). METHODS:Fifty-nine patients (21 male, 38 female) with...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-011-2244-x
更新日期:2012-01-01 00:00:00
abstract::The majority of abnormal findings or lesions on T2-weighted fast spin-echo (FSE) magnetic resonance imaging (MRI) are hyperintense due to increased perfusion or fluid content, such as infections, tumours or synovitis. Hypointense lesions on T2-weighted images (both fat-suppressed and non-fat-suppressed) are less commo...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-015-4027-2
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVES:To clarify the changes in organic anion-transporting polypeptide 8 (OATP8) expression and enhancement ratio on gadoxetic acid-enhanced MR imaging in hepatocellular nodules during multistep hepatocarcinogenesis. METHODS:In imaging analysis, we focused on 71 surgically resected hepatocellular carcinomas (well...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-011-2165-8
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the effect of bilateral salpingo-oophorectomy (BSO) on background parenchymal enhancement (BPE) and the amount of fibroglandular tissue (FGT) seen on breast MRI. METHODS:Retrospective review identified 21 BRCA mutation carriers who underwent breast MRI before and a...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-2993-9
更新日期:2014-01-01 00:00:00
abstract::The aim of this study was to evaluate inter- and intra-observer reproducibility when making electronic caliper linear tumor measurements on picture archiving and communications systems (PACS) and compare them with linear measurements obtained from circumferential tracing of tumor perimeter. Three radiologists measured...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-003-2027-0
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVES:To compare treatment outcomes of subcentimeter hypervascular nodules at high risk for developing into hepatocellular carcinomas (SHNHR) between early treatment and watchful waiting until progression to overt hepatocellular carcinoma (HCC) groups. METHODS:SHNHRs were defined as subcentimeter hypervascular no...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-4818-8
更新日期:2017-10-01 00:00:00
abstract::Percutaneous thrombectomy (PT) is an established technique for the removal of acute thrombus in occluded arteries, veins and vascular grafts. Percutaneous thrombectomy can be used as an adjunctive treatment to other methods of thrombus removal such as thrombolysis or as sole therapy. The two main methods are percutane...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s003300101014
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVES:The clinical presentation of peripheral artery disease (PAD) and chronic venous insufficiency (CVI) can overlap and the conditions may co-exist. The purpose of our study was to investigate the prevalence and clinical significance of concomitant CVI in patients with PAD examined with run-off MR angiography (M...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06696-x
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:Hypoxia is associated with poor prognosis and treatment resistance in breast cancer. However, the temporally variant nature of hypoxia can complicate interpretation of imaging findings. We explored the relationship between hypoxia and vascular function in breast tumours through combined 18F-fluoromisonidazol...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07067-2
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVES:This prospective trial was performed to verify whether microwave ablation (MWA) in combination with chemotherapy could provide superior survival benefit compared with chemotherapy alone. MATERIALS AND METHODS:From March 1, 2015, to June 20, 2017, treatment-naïve patients with pathologically verified advance...
journal_title:European radiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00330-019-06613-x
更新日期:2020-05-01 00:00:00
abstract::Endovascular treatment options for visceral artery pseudoaneurysms depend on lesion location and size. Exclusion methods fall into two categories, embolization and stent placement, and these procedures aim to exclude the pseudoaneurysm from the circulation and if possible to maintain distal blood flow. Embolization of...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-008-1053-3
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the risk factors affecting early diffuse recurrence within 1 year of percutaneous ultrasound-guided radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). METHODS:Out of 146 patients who received transcatheter arterial chemoembolisation (TACE) for treatment of recurrent HCC after percu...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2561-8
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:Evaluate the ability of MR diffusion-weighted imaging (DWI) to predict patency capsule retention in Crohn's disease (CD). METHODS:Clinical and imaging data were prospectively reviewed for 80 CD patients following patency capsule administration and MR-DWI under institutional review board (IRB) approval with ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-4857-1
更新日期:2017-12-01 00:00:00
abstract::An aberrant channel was identified on CT in the petrous bone in four patients presenting with unrelated otological symptoms. These channels occurred unilaterally in each case. In two patients, the channel was seen to run between the sigmoid sinus sulcus and the superior petrosal sinus sulcus; in one of these patients,...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-009-1492-5
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVES:To investigate the survival benefit of transarterial chemoembolization (TACE) plus Iodine125 seed implantation (TACE-Iodine125) in hepatitis B-related HCC patients with portal vein tumour thrombus (PVTT) and the underlying prognostic factors. METHODS:A retrospective matched cohort study was performed on con...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-4198-x
更新日期:2016-10-01 00:00:00