Abstract:
OBJECTIVES:This prospective trial was performed to verify whether microwave ablation (MWA) in combination with chemotherapy could provide superior survival benefit compared with chemotherapy alone. MATERIALS AND METHODS:From March 1, 2015, to June 20, 2017, treatment-naïve patients with pathologically verified advanced or recurrent non-small cell lung cancer (NSCLC) were randomly assigned to MWA plus chemotherapy group or chemotherapy group. The primary endpoint was progression-free survival (PFS), while the secondary endpoints included overall survival (OS), time to local progression (TTLP), and objective response rate (ORR). The complications and adverse events were also reported. RESULTS:A total of 293 patients were randomly assigned into the two groups. One hundred forty-eight patients with 117 stage IV tumors were included in the MWA plus chemotherapy group. One hundred forty-five patients with 113 stage IV tumors were included in the chemotherapy group. The median follow-up period was 13.1 months and 12.4 months, respectively. Median PFS was 10.3 months (95% CI 8.0-13.0) in the MWA plus chemotherapy group and 4.9 months (95% CI 4.2-5.7) in the chemotherapy group (HR = 0.44, 95% CI 0.28-0.53; p < 0.0001). Median OS was not reached in the MWA plus chemotherapy group and 12.6 months (95% CI 10.6-14.6) in the chemotherapy group (HR = 0.38, 95% CI 0.27-0.53; p < 0.0001) using Kaplan-Meier analyses with log-rank test. The median TTLP was 24.5 months, and the ORR was 32% in both groups. The adverse event rate was not significantly different in the two groups. CONCLUSIONS:In patients with advanced NSCLC, longer PFS and OS can be achieved with the treatment of combined MWA and chemotherapy than chemotherapy alone. KEY POINTS:• Patients treated with MWA plus chemotherapy had superior PFS and OS over those treated with chemotherapy alone. • The ORR of patients treated with MWA plus chemotherapy was similar to that of those treated with chemotherapy alone. • Complications associated with MWA were common but tolerable and manageable.
journal_name
Eur Radioljournal_title
European radiologyauthors
Wei Z,Yang X,Ye X,Feng Q,Xu Y,Zhang L,Sun W,Dong Y,Meng Q,Li T,Wang C,Li G,Zhang K,Li P,Bi J,Xue G,Sun Y,Sheng L,Liu B,Yu G,Ren H,Wang J,Sun L,Chen S,Geng D,Zhang B,Xu X,Zhang L,Sun D,Xu X,Diaodoi
10.1007/s00330-019-06613-xsubject
Has Abstractpub_date
2020-05-01 00:00:00pages
2692-2702issue
5eissn
0938-7994issn
1432-1084pii
10.1007/s00330-019-06613-xjournal_volume
30pub_type
杂志文章,多中心研究,随机对照试验abstract::This pictorial review illustrates the anatomical features of normal intra-articular components of the hip and their common disorders on MR arthrography. On T1-weighted MR arthrograms, the normal contrast-filled joint cavity shows a homogeneous high signal intensity. Normal acetabular labrum appears as a well-delineate...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s003300050009
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:To evaluate whether post-contrast cone-beam breast CT (CBBCT) alone is comparable to the current standard of combined pre- and post-contrast CBBCT regarding diagnostic accuracy and superior regarding radiation exposure. MATERIAL AND METHODS:This study included 49 women (61 breasts) with median age 57.9 year...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5854-8
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:To compare imaging findings with histopathology in AML without visible fat (AMLwvf). MATERIAL AND METHODS:With IRB approval, we identified 18 AMLwvf that underwent CT between 2002-2014. A radiologist measured NECT-attenuation, corticomedullary (CM) and nephrographic (NG) enhancement, echogenicity relative to...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-3851-8
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVES:To evaluate the accuracy of high-pitch delayed enhancement (DE) CT for the assessment of myocardial viability with MRI as the reference standard. METHODS:Twenty-four patients (mean age 66.9 ± 9.2 years) with coronary artery disease underwent DE imaging with 128-slice dual-source CT (prospective electrocardi...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-011-2149-8
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:To evaluate visualization of the right adrenal vein (RAV) with multidetector CT and non-contrast-enhanced MR imaging in patients with primary aldosteronism. METHODS:A total of 125 patients (67 men) scheduled for adrenal venous sampling (AVS) were included. Dynamic 64-detector-row CT and balanced steady-stat...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-3872-3
更新日期:2016-03-01 00:00:00
abstract::The purpose was to evaluate low-dose CT colonography without cathartic cleansing in terms of image quality, polyp visualization and patient acceptance. Sixty-one patients scheduled for colonoscopy started a low-fiber diet, lactulose and amidotrizoic-acid for fecal tagging 2 days prior to the CT scan (standard dose, 5....
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-007-0668-0
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVE:Despite 90 % of glioblastoma (GBM) recurrences occurring in the peritumoral brain zone (PBZ), its contribution in patient survival is poorly understood. The current study leverages computerized texture (i.e. radiomic) analysis to evaluate the efficacy of PBZ features from pre-operative MRI in predicting long-...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4637-3
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVES:To evaluate the diagnostic performance of arterial spin labelling perfusion weighted images (ASL-PWIs) to differentiate primary CNS lymphoma (PCNSL) from glioblastoma (GBM). METHODS:ASL-PWIs of pathologically confirmed PCNSL (n = 21) or GBM (n = 93) were analysed. For qualitative analysis, tumours were visu...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5359-5
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVES:We wished to determine whether tumor morphology descriptors obtained from pretreatment magnetic resonance images and clinical variables could predict survival for glioblastoma patients. METHODS:A cohort of 404 glioblastoma patients (311 discoveries and 93 validations) was used in the study. Pretreatment vol...
journal_title:European radiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00330-018-5758-7
更新日期:2019-04-01 00:00:00
abstract::We report a case of a 22-year-old male with Hunter syndrome who developed progressive major airway obstruction and was treated with insertion of plastic and metallic stents, with dramatic improvement in the patient's symptomatic and functional status. To the best of our knowledge, this is the first reported case of en...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300100932
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to examine whether visual MRI rating scales used in diagnostics of cognitive disorders can be estimated computationally and to compare the visual rating scales with their computed counterparts in differential diagnostics. METHODS:A set of volumetry and voxel-based morphometry ima...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-019-06067-1
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVES:Duchenne muscular dystrophy (DMD) is the most common and severe dystrophinopathy. DMD carriers rarely present with clinical symptoms, but may suffer from cardiac involvement. Because echocardiographic findings are inconsistent and cardiac magnetic resonance imaging (CMRI) data are limited, this study sought ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-3694-3
更新日期:2015-10-01 00:00:00
abstract::The objective of our work was to evaluate the long-term results of percutaneous ethanol injection (PEI) for the treatment of hepatocellular carcinoma (HCC) in patients with liver cirrhosis. A total of 184 cirrhotic patients with HCC underwent PEI as the only anticancer treatment over an 8-year period. Patients were fo...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050194
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:This tertiary care experience examines the utility of magnetic resonance neurography (MRN) in the management of peripheral trigeminal neuropathies. MATERIALS AND METHODS:Seventeen patients with clinically suspected peripheral trigeminal neuropathies (inferior alveolar nerve and lingual nerve) were imaged uni...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-4182-5
更新日期:2016-10-01 00:00:00
abstract::Treatment of the superficial femoral artery (SFA) has been among the least effective of all endovascular procedures in terms of long-term patency. The relatively small vessel lumen, in conjunction with a high plaque burden, slow flow, and a high frequency of primary occlusions, contributes to a considerable rate of ac...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-005-0111-3
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVES:Coronary artery volume indexed to left myocardial mass (CAVi), derived from coronary computed tomography angiography (CCTA), has been proposed as an indicator of diffuse atherosclerosis. We investigated the association of CAVi with quantitative flow parameters and its ability to predict ischemia as derived f...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07586-y
更新日期:2021-01-16 00:00:00
abstract::The gamekeeper's or skier's thumb is a very common injury. Nondisplaced tears of the ulnar collateral ligament of the thumb (UCL) may be treated conservatively. For that reason an accurate diagnosis is mandatory for choosing the correct therapy. Ultrasound is able to depict the position of the torn UCL correctly in ap...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050111
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:We aimed to determine the timing for assessing birth status of the developing brain (i.e. brain maturity at birth) by exploring the postnatal age-related changes in neonatal brain white matter (WM). METHODS:The institutional review board approved this study and all informed parental consents were obtained. 1...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5665-y
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:To test the feasibility of four-dimensional (4D) flow MRI to quantify the systolic wall shear stress (WSSsystole) and oscillatory shear index (OSI) in high-grade internal carotid artery (ICA) stenosis before and after endarterectomy (CEA). METHODS:Twenty patients with ≥60 % ICA stenosis were prospectively a...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-2953-4
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVES:To analyse the implementation, applicability and accuracy of the pretest probability calculation provided by NICE clinical guideline 95 for decision making about imaging in patients with chest pain of recent onset. METHODS:The definitions for pretest probability calculation in the original Duke clinical sco...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5322-5
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:To prospectively compare reduced-dose (RD) CT colonography (CTC) with standard-dose (SD) imaging using several reconstruction algorithms. METHODS:Following SD supine CTC, 40 patients (mean age, 57.3 years; 17 M/23 F; mean BMI, 27.2) underwent an additional RD supine examination (targeted dose reduction, 70-9...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-3603-9
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVES:Many radiologists and clinicians still consider multiple myeloma (MM) and monoclonal gammopathies (MG) a contraindication for using iodine-based contrast media. The ESUR Contrast Media Safety Committee performed a systematic review of the incidence of post-contrast acute kidney injury (PC-AKI) in these patie...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-017-5023-5
更新日期:2018-02-01 00:00:00
abstract::The original version of this article, published on 27 May 2019, unfortunately contained a mistake. The following correction has therefore been made in the original. ...
journal_title:European radiology
pub_type: 已发布勘误
doi:10.1007/s00330-019-06333-2
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:This study aims to investigate whether aneurysm wall enhancement (AWE) is independently associated with symptomatic status of unruptured intracranial aneurysms (UIAs). METHODS:One hundred thirty-nine consecutive patients (67 male, mean age 58 ± 11 years) with 79 symptomatic and 87 asymptomatic UIAs were imag...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07063-6
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:The progression of white matter hyperintensities (WMH) varies considerably in adults. In this study, we aimed to predict the progression and related risk factors of WMH based on the radiomics of whole-brain white matter (WBWM). METHODS:A retrospective analysis was conducted on 141 patients with WMH who under...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06676-1
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVES:To compare tumour enhancement patterns measured using dynamic contrast-enhanced (DCE)-CT with tumour metabolism measured using positron emission tomography (PET)-CT in patients with non-small cell lung cancer (NSCLC) and stable disease after chemotherapy or chemoradiotherapy. METHODS:After treatment, 75 NSC...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2755-0
更新日期:2013-06-01 00:00:00
abstract::A "quadraphasic" imaging technique is described for imaging malignancies of the abdomen (liver, kidneys and pancreas). With this technique images are acquired during four different phases relative to the administration of contrast agent: pre-contrast (baseline), during the capillary (arterial, pre-sinusoidal) phase, d...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/pl00006899
更新日期:1997-01-01 00:00:00
abstract::The purpose was to evaluate whether B-flow can improve the ultrasonographic diagnosis of preocclusive stenosis and occlusion of the internal carotid artery (ICA) compared with colour-coded Doppler and power Doppler. Ninety patients with occlusions or preocclusive stenoses of the ICA suspected by Doppler sonography wer...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-006-0285-3
更新日期:2007-02-01 00:00:00
abstract::Intussusception represents the most common abdominal emergency in infancy. The classical clinical triad, consisting of abdominal colics, red jelly stools and a palpable mass, is only present in approximately 50% of cases, 20% of patients are symptom free at clinical presentation. Primary imaging modality of choice is ...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-003-2033-2
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the diagnostic performance of automated coronary atherosclerotic plaque quantification (QCT) by different users (expert/non-expert/automatic). METHODS:One hundred fifty coronary artery segments from 142 patients who underwent coronary computed tomography angiography (CCTA) and intravascular ultra...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-3698-z
更新日期:2015-10-01 00:00:00