Abstract:
OBJECTIVES:The purpose of this study was to investigate the association of relaxation-compensated chemical exchange saturation transfer (CEST) MRI with overall survival (OS) and progression-free survival (PFS) in newly diagnosed high-grade glioma (HGG) patients. METHODS:Twenty-six patients with newly diagnosed high-grade glioma (WHO grades III-IV) were included in this prospective IRB-approved study. CEST MRI was performed on a 7.0-T whole-body scanner. Association of patient OS/PFS with relaxation-compensated CEST MRI (amide proton transfer (APT), relayed nuclear Overhauser effect (rNOE)/NOE, downfield-rNOE-suppressed APT (dns-APT)) and diffusion-weighted imaging (apparent diffusion coefficient) were assessed using the univariate Cox proportional hazards regression model. Hazard ratios (HRs) and corresponding 95% confidence intervals were calculated. Furthermore, OS/PFS association with clinical parameters (age, gender, O6-methylguanine-DNA methyltransferase (MGMT) promotor methylation status, and therapy: biopsy + radio-chemotherapy vs. debulking surgery + radio-chemotherapy) were tested accordingly. RESULTS:Relaxation-compensated APT MRI was significantly correlated with patient OS (HR = 3.15, p = 0.02) and PFS (HR = 1.83, p = 0.009). The strongest association with PFS was found for the dns-APT metric (HR = 2.61, p = 0.002). These results still stand for the relaxation-compensated APT contrasts in a homogenous subcohort of n = 22 glioblastoma patients with isocitrate dehydrogenase (IDH) wild-type status. Among the tested clinical parameters, patient age (HR = 1.1, p = 0.001) and therapy (HR = 3.68, p = 0.026) were significant for OS; age additionally for PFS (HR = 1.04, p = 0.048). CONCLUSION:Relaxation-compensated APT MRI signal intensity is associated with overall survival and progression-free survival in newly diagnosed, previously untreated glioma patients and may, therefore, help to customize treatment and response monitoring in the future. KEY POINTS:• Amide proton transfer (APT) MRI signal intensity is associated with overall survival and progression in glioma patients. • Relaxation compensation enhances the information value of APT MRI in tumors. • Chemical exchange saturation transfer (CEST) MRI may serve as a non-invasive biomarker to predict prognosis and customize treatment.
journal_name
Eur Radioljournal_title
European radiologyauthors
Paech D,Dreher C,Regnery S,Meissner JE,Goerke S,Windschuh J,Oberhollenzer J,Schultheiss M,Deike-Hofmann K,Bickelhaupt S,Radbruch A,Zaiss M,Unterberg A,Wick W,Bendszus M,Bachert P,Ladd ME,Schlemmer HPdoi
10.1007/s00330-019-06066-2subject
Has Abstractpub_date
2019-09-01 00:00:00pages
4957-4967issue
9eissn
0938-7994issn
1432-1084pii
10.1007/s00330-019-06066-2journal_volume
29pub_type
杂志文章abstract:OBJECTIVES:To assess the performance of gadoxetate dynamic contrast-enhanced (DCE) MRI of the liver and spleen for noninvasive diagnosis of portal hypertension (PH). METHODS:Thirty-five patients (M/F 22/13, mean age 55 years) with chronic liver disease who underwent hepatic venous pressure gradient (HVPG) measurements...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07495-0
更新日期:2021-01-07 00:00:00
abstract:OBJECTIVES:Time-resolved contrast-enhanced MR angiography (4D-MRA), which allows the simultaneous visualization of the vasculature and blood-flow dynamics, is widely used in clinical routine. In this study, the impact of two different contrast agent injection methods on 4D-MRA was examined in a controlled, standardized...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-5178-0
更新日期:2018-05-01 00:00:00
abstract::Gadoxetic acid-enhanced magnetic resonance imaging (MRI) plays important roles in diagnosis of hepatic lesions because of its superiority in the detectability of small lesions, its differentiation ability, and its utility for the early diagnosis of hepatocellular carcinoma (HCC). In HCC, expression of organic anion tr...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-020-06687-y
更新日期:2020-06-01 00:00:00
abstract::Stress fractures are common injuries frequently overlooked on first radiographs, especially in the early course. The gold standard for accurate diagnosis is MRI and scintigraphy. We report six cases of stress fractures of the lower limb diagnosed with sonography and describe typical sonographic features. ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-004-2525-8
更新日期:2005-02-01 00:00:00
abstract::The influence of the frequency of computed tomography (CT) image acquisition on the diagnostic quality of dynamic perfusion CT (PCT) studies of the brain was investigated. Eight patients with clinically suspected acute ischemia of one hemisphere underwent PCT, performed on average 3.4 h after the onset of symptoms. Si...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-008-1083-x
更新日期:2008-12-01 00:00:00
abstract::Magnetization transfer (MT) provides post-gadolinium contrast improvement through decreasing the tissue signal. Our study had two aims: to analyse the effect of MT qualitatively and quantitatively in 13 patients, and to analyse in vitro the competition between two relaxation phenomena, dipole-dipole which is character...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/pl00006889
更新日期:1997-01-01 00:00:00
abstract::To prove the usefulness of a simple laser marker system (LMS) in target definition as well as examination procedure for CT-guided interventions, 130 cases of diagnostic biopsies and lumbal sympathectomies were compared. In 75 cases LMS and in 55 cases a simple crossgrid was used. Taking advantage of the LMS, the param...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300051054
更新日期:2000-01-01 00:00:00
abstract::The aim of this study is to evaluate the usefulness of diffusion-weighted (DW) magnetic resonance (MR) imaging in detecting peritoneal dissemination in cases of gynecological malignancy. We retrospectively analyzed MR images obtained from 26 consecutive patients with gynecological malignancy. Peritoneal dissemination ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-007-0732-9
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:To describe the normal linear measurements of the skull (bi-parietal diameter and occipito-frontal diameter) and intracranial volumes (ventricular volume, brain parenchymal volume, extra-axial volume and total intra-cranial volume) in normal fetuses. MATERIALS AND METHODS:We recruited pregnant women from low-r...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5938-5
更新日期:2019-07-01 00:00:00
abstract:AIM:To describe the effect of hepatobiliary-specific MR imaging contrast agent (HBCA) administration on the signal intensity of peritoneal and pleural fluid effusions on T1-weighted MR images. MATERIALS AND METHODS:From October 2015 to May 2016 139 patients (mean 60±10 years old, 69 % males) with peritoneal or pleural...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-5261-6
更新日期:2018-07-01 00:00:00
abstract::Hepatobiliary contrast agents with uptake into hepatocytes followed by variable biliary excretion represent a unique class of cell-specific MR contrast agents. Two hepatobiliary contrast agents, mangafodipir trisodium and gadobenate dimeglumine, are already clinically approved. A third hepatobiliary contrast agent, Gd...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-004-2236-1
更新日期:2004-04-01 00:00:00
abstract::The purpose was to evaluate whether B-flow can improve the ultrasonographic diagnosis of preocclusive stenosis and occlusion of the internal carotid artery (ICA) compared with colour-coded Doppler and power Doppler. Ninety patients with occlusions or preocclusive stenoses of the ICA suspected by Doppler sonography wer...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-006-0285-3
更新日期:2007-02-01 00:00:00
abstract::Spinal vascular malformations are rare diseases that consist of true inborn cavernomas and arteriovenous malformations (including perimedullary fistulae, glomerular and juvenile AVMs) and presumably acquired dural arteriovenous fistulae. This review article gives an overview of the imaging features both on MRI and ang...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-004-2510-2
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVES:Hypoxia is associated with poor prognosis and treatment resistance in breast cancer. However, the temporally variant nature of hypoxia can complicate interpretation of imaging findings. We explored the relationship between hypoxia and vascular function in breast tumours through combined 18F-fluoromisonidazol...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07067-2
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVES:To describe the pathological appearance of the anterolateral ligament (ALL) on US and MRI in knees with an anterior cruciate ligament (ACL) tear. METHODS:This prospective study included 30 patients who had a suspected acute ACL tear. Their injured and contralateral knees were evaluated with radiography, US ...
journal_title:European radiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00330-017-4955-0
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:The study aimed to determine which hemodynamic parameters independently characterize anterior communicating artery (AcomA) aneurysm formation and explore the threshold of wall shear stress (WSS) of the parent artery to better illustrate the correlation between the magnitude of WSS and AcomA aneurysm formatio...
journal_title:European radiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00330-018-5624-7
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVES:To predict the probability of malignancy for MRI-detected breast lesions with a multivariate model incorporating patient and lesion characteristics. METHODS:Retrospective review of 2565 breast MR examinations from 1/03-11/06. BI-RADS 3, 4 and 5 lesions initially detected on MRI for new cancer or high-risk s...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-011-2094-6
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVES:To compare 0.15 mmol/kg gadobutrol for late gadolinium enhancement (LGE) imaging of chronic myocardial infarction with a relaxivity-adjusted dose of gadoterate meglumine (Gd-DOTA). METHODS:Seventeen patients with suspected chronic myocardial infarction underwent LGE imaging at 1.5 T, acquiring an inversion-...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2563-6
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:Fractional flow reserve computed tomography (FFRCT) depends upon nitroglycerin (NTG) inducing maximal hyperemia. However, the impact of NTG dosages on FFRCT analysis including coronary volume-to-mass ratio (V/M) is unknown. METHODS:Eighty patients with repeat coronary CT angiograms (CCTAs) with different su...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-019-06293-7
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the diagnostic performance of automated coronary atherosclerotic plaque quantification (QCT) by different users (expert/non-expert/automatic). METHODS:One hundred fifty coronary artery segments from 142 patients who underwent coronary computed tomography angiography (CCTA) and intravascular ultra...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-3698-z
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:This retrospective study aims to assess the accuracy of two-phase computed tomography (CT) and transoesophageal echocardiography (TEE) for the detection of left atrial (LA) thrombus in patients with mitral stenosis (MS) and atrial fibrillation (AF), by using intraoperative findings as the reference standard. ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-2944-5
更新日期:2013-11-01 00:00:00
abstract::The aim of this study was to find out by radiological analysis whether it is possible to prevent interval cancers in screening programmes without a concomitant increase in false positives. Re-scrutiny of all mammograms of 544 interval cancers was implemented. Blinded re-scrutiny of screening mammograms of 390 interval...
journal_title:European radiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/s003300050452
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:To assess whether with recent MR technology current patient preparation literature recommendations for female pelvic MRI are still valid and how they are influencing the position of the female pelvic organs, image quality, and diagnostic confidence. METHODS:This prospective study was performed in two centre...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06869-8
更新日期:2020-10-01 00:00:00
abstract::Bilateral tuberculous mastoiditis (TOM) in an immunocompetent child is a very uncommon form of tuberculous infection presentation. This report shows the CT and MR imaging of bilateral tuberculous otomastoiditis consisting of aggressive signs of middle ear and mastoid involvement with bony destruction and periauricular...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-008-1130-7
更新日期:2009-06-01 00:00:00
abstract::Methods of imaging and intervention in acute non-traumatic vascular arterial conditions has changed substantially during recent years. Computed tomography, MRI angiography and, more recently, intravascular ultrasonography (IVUS) have replaced to a large extent conventional diagnostic angiography. An increasing number ...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-002-1526-8
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVES:To assess the accuracy and efficiency of a threshold-based, semi-automated cardiac MRI segmentation algorithm in comparison with conventional contour-based segmentation and aortic flow measurements. METHODS:Short-axis cine images of 148 patients (55 ± 18 years, 81 men) were used to evaluate left ventricular...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-3952-4
更新日期:2016-05-01 00:00:00
abstract::While high-resolution T1-weighted sequences, such as three-dimensional magnetization-prepared rapid gradient-echo imaging, are widely available, there is a lack of an equivalent fast high-resolution sequence providing T2 contrast. Using fast high-performance gradient systems we show the feasibility of three-dimensiona...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-003-1846-3
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVES:Normative brain volume reports (NBVRs) are becoming more and more available for the workup of dementia patients in clinical routine. However, it is yet unknown how this information can be used in the radiological decision-making process. The present study investigates the diagnostic value of NBVRs for detect...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-019-06602-0
更新日期:2020-05-01 00:00:00
abstract::The aim of this study was to analyze the precision of tibial cartilage morphometry, by using a fast, coronal water-excitation sequence with high spatial resolution, to compare the reproducibility of 3D thickness vs volume estimates, and to test the technique in patients with severe osteoarthritis. The tibiae of 8 heal...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050047
更新日期:2000-01-01 00:00:00
abstract::The diagnostic approach for evaluation of adrenal tumour in pregnant women is a problem. This article presents the multifactorial diagnosis of rare, incidentally detected massive adrenal tumour with 2D and 3D US. Grey-scale 2D and 3D US with tissue harmonic imaging showed inhomogeneous, encapsulated, solid tumour of t...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-002-1457-4
更新日期:2002-12-01 00:00:00