Probability of malignancy for lesions detected on breast MRI: a predictive model incorporating BI-RADS imaging features and patient characteristics.


OBJECTIVES:To predict the probability of malignancy for MRI-detected breast lesions with a multivariate model incorporating patient and lesion characteristics. METHODS:Retrospective review of 2565 breast MR examinations from 1/03-11/06. BI-RADS 3, 4 and 5 lesions initially detected on MRI for new cancer or high-risk screening were included and outcomes determined by imaging, biopsy or tumor registry linkage. Variables were indication for MRI, age, lesion size, BI-RADS lesion type and kinetics. Associations with malignancy were assessed using generalized estimating equations and lesion probabilities of malignancy were calculated. RESULTS:855 lesions (155 malignant, 700 benign) were included. Strongest associations with malignancy were for kinetics (washout versus persistent; OR 4.2, 95% CI 2.5-7.1) and clinical indication (new cancer versus high-risk screening; OR 3.0, 95% CI 1.7-5.1). Also significant were age > = 50 years, size > = 10 mm and lesion-type mass. The most predictive model (AUC 0.70) incorporated indication, size and kinetics. The highest probability of malignancy (41.1%) was for lesions on MRI for new cancer, > = 10 mm with washout. The lowest (1.2%) was for lesions on high-risk screening, <10 mm with persistent kinetics. CONCLUSIONS:A multivariate model shows promise as a decision support tool in predicting malignancy for MRI-detected breast lesions.


Eur Radiol


European radiology


Demartini WB,Kurland BF,Gutierrez RL,Blackmore CC,Peacock S,Lehman CD




Has Abstract


2011-08-01 00:00:00












  • 2D SPLASH: a new method to determine the fatty infiltration of the rotator cuff muscles.

    abstract::The objective of this paper is to quantify the fatty degeneration (infiltration) of rotator cuff muscles with a new spectroscopic FLASH (SPLASH) sequence. Before planned surgery (reconstruction or muscle transfer), 20 patients (13 men, 7 women; 35-75 years) with different stages of rotator cuff disease underwent an MR...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Kenn W,Böhm D,Gohlke F,Hümmer C,Köstler H,Hahn D

    更新日期:2004-12-01 00:00:00

  • Heterotropic mesenteric ossification: a case report (2004:10b).

    abstract::Heterotropic mesenteric ossification is a rare entity. Only a few cases have been described in the literature. We report a case of heterotropic mesenteric ossification in a patient who underwent several laparotomies, after suffering from multiple gunshot wounds. We discuss the radiographic findings of this disease tha...

    journal_title:European radiology

    pub_type: 杂志文章,评审


    authors: Tonino BA,van der Meulen HG,Kuijpers KC,Mallens WM,van Gils AP

    更新日期:2005-01-01 00:00:00

  • Morphological and functional imaging in COPD with CT and MRI: present and future.

    abstract::Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. COPD is defined by irreversible airflow obstruction. It is a heterogeneous disease affecting the airways (i.e. chronic bronchitis, airway collapse), the parenchyma (i.e. hyperinflation, air trapping and emph...

    journal_title:European radiology

    pub_type: 杂志文章,评审


    authors: Ley-Zaporozhan J,Ley S,Kauczor HU

    更新日期:2008-03-01 00:00:00

  • Meta-analysis: adjusted indirect comparison of drug-eluting bead transarterial chemoembolization versus 90Y-radioembolization for hepatocellular carcinoma.

    abstract:OBJECTIVE:To investigate comparative effectiveness of drug-eluting bead transarterial chemoembolization (DEB-TACE) versus Yttrium-90 (90Y)-radioembolization for hepatocellular carcinoma (HCC). METHODS:Studies comparing conventional (c)TACE versus 90Y-radioembolization or DEB-TACE for HCC treatment were identified usin...

    journal_title:European radiology

    pub_type: 杂志文章,meta分析


    authors: Ludwig JM,Zhang D,Xing M,Kim HS

    更新日期:2017-05-01 00:00:00

  • Early post-operative magnetic resonance imaging in glioblastoma: correlation among radiological findings and overall survival in 60 patients.

    abstract:OBJECTIVES:To evaluate early post-operative magnetic resonance (EPMR) as a prognostic tool after resection of glioblastoma. METHODS:Sixty EPMR examinations were evaluated for perioperative infarct, tumour growth between diagnosis and EPMR, contrast enhancement pattern, and extent of resection (EOR). The EOR was approa...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Majós C,Cos M,Castañer S,Gil M,Plans G,Lucas A,Bruna J,Aguilera C

    更新日期:2016-04-01 00:00:00

  • Dynamic MR colpocystorectography assessing pelvic-floor descent.

    abstract::Magnetic resonance colpocystorectography (MR-CCRG) is presented in the evaluation of patients with pelvic-floor disorders. Five healthy volunteers and 44 female patients with isolated or combined visceral descent underwent dynamic MRI and dynamic fluoroscopy (DF). MR-CCRG was performed with the patient in a supine pos...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Lienemann A,Anthuber C,Baron A,Kohz P,Reiser M

    更新日期:1997-01-01 00:00:00

  • Quantitative multivoxel 1H MR spectroscopy of the brain in children with acute liver failure.

    abstract::Acute liver failure (ALF)-related encephalopathy was previously characterized by MR spectroscopy of single voxels containing both grey and white matter brain tissue. Quantitative multivoxel MRS was used here to compare grey and white matter brain tissue concentrations of glutamate/glutamine (Glx) and lactate in ALF an...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Sijens PE,Alkefaji H,Lunsing RJ,van Spronsen FJ,Meiners LC,Oudkerk M,Verkade HJ

    更新日期:2008-11-01 00:00:00

  • Gastrointestinal infection in the immunocompromised (AIDS) patient.

    abstract::In the past two decades acquired immunodeficiency syndrome (AIDS) has become one of the most devastating illnesses in human history. As the epidemic continues to spread increasingly, AIDS patients are no longer confined to a few specialized AIDS hospitals and are now seen in general hospitals and clinics everywhere. R...

    journal_title:European radiology

    pub_type: 杂志文章,评审


    authors: Reeders JW,Yee J,Gore RM,Miller FH,Megibow AJ

    更新日期:2004-03-01 00:00:00

  • Analysis of normal-appearing white matter of multiple sclerosis by tensor-based two-compartment model of water diffusion.

    abstract:OBJECTIVES:To compare the significance of the two-compartment model, considering diffusional anisotropy with conventional diffusion analyzing methods regarding the detection of occult changes in normal-appearing white matter (NAWM) of multiple sclerosis (MS). METHODS:Diffusion-weighted images (nine b-values with six d...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Tachibana Y,Obata T,Yoshida M,Hori M,Kamagata K,Suzuki M,Fukunaga I,Kamiya K,Yokoyama K,Hattori N,Inoue T,Aoki S

    更新日期:2015-06-01 00:00:00

  • Radiomics from magnetic resonance imaging may be used to predict the progression of white matter hyperintensities and identify associated risk factors.

    abstract:OBJECTIVE:The progression of white matter hyperintensities (WMH) varies considerably in adults. In this study, we aimed to predict the progression and related risk factors of WMH based on the radiomics of whole-brain white matter (WBWM). METHODS:A retrospective analysis was conducted on 141 patients with WMH who under...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Shu Z,Xu Y,Shao Y,Pang P,Gong X

    更新日期:2020-06-01 00:00:00

  • Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with ¹⁵O-H₂O PET.

    abstract:OBJECTIVES:This study introduces a method to calculate myocardium blood flow (MBF) and coronary flow reserve (CFR) using the relatively low-dose dynamic 320-row multi-detector computed tomography (MDCT), validates the method against (15)O-H₂O positron-emission tomography (PET) and assesses the CFRs of coronary artery d...

    journal_title:European radiology

    pub_type: 杂志文章,随机对照试验


    authors: Kikuchi Y,Oyama-Manabe N,Naya M,Manabe O,Tomiyama Y,Sasaki T,Katoh C,Kudo K,Tamaki N,Shirato H

    更新日期:2014-07-01 00:00:00

  • Comparison of volumetric and functional parameters in simultaneous cardiac PET/MR: feasibility of volumetric assessment with residual activity from prior PET/CT.

    abstract:OBJECTIVE:To compare cardiac left ventricular (LV) parameters in simultaneously acquired hybrid fluorine-18-fluorodeoxyglucose ([18F] FDG) positron emission tomography/magnetic resonance imaging (PET/MRI) in patients with residual tracer activity of upstream PET/CT. METHODS:Twenty-nine patients (23 men, age 58±17 year...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Lücke C,Oppolzer B,Werner P,Foldyna B,Lurz P,Jochimsen T,Brenneis B,Lehmkuhl L,Sattler B,Grothoff M,Barthel H,Sabri O,Gutberlet M

    更新日期:2017-12-01 00:00:00

  • Differentiation of predominant subtypes of lung adenocarcinoma using a quantitative radiomics approach on CT.

    abstract:OBJECTIVES:To develop a model for differentiating the predominant subtype-based prognostic groups of lung adenocarcinoma using CT radiomic features, and to validate its performance in comparison with radiologists' assessments. METHODS:A total of 993 patients presenting with invasive lung adenocarcinoma between March 2...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Park S,Lee SM,Noh HN,Hwang HJ,Kim S,Do KH,Seo JB

    更新日期:2020-09-01 00:00:00

  • Interventional CT: 30 years' experience.

    abstract::CT-guided procedures remain an important tool for diagnosis and tissue acquisition for primary diagnosis and molecular/tissue correlation. New imaging devices such as MDCT and PET/CT will improve diagnosis but percutaneous procedures will be needed to confirm and support new molecular and DNA treatments. Coagulopathic...

    journal_title:European radiology

    pub_type: 杂志文章,评审


    authors: Haaga JR

    更新日期:2005-11-01 00:00:00

  • Automated CT volumetry of pulmonary metastases: the effect of a reduced growth threshold and target lesion number on the reliability of therapy response assessment using RECIST criteria.

    abstract::The purpose of this study was to evaluate the reproducibility of CT-volumetric tumour response assessment of pulmonary metastasis using variable volume change thresholds (VCT) and target lesions with response evaluation criteria in solid tumours (RECIST). Fifty consecutive patients with pulmonary metastases undergoing...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Marten K,Auer F,Schmidt S,Rummeny EJ,Engelke C

    更新日期:2007-10-01 00:00:00

  • Retrospective measurement of different size parameters of non-radiated rectal cancer on MR images and pathology slides and their comparison.

    abstract::There are no non-invasive methods to assess the real tumor size in rectal cancer prior to surgery, especially following radio/chemotherapy. Magnetic resonance imaging is gaining increasing acceptance as the primary modality at many centers for evaluation of pelvic malignancies including rectal cancers. The aim of this...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Torkzad M,Lindholm J,Martling A,Blomqvist L

    更新日期:2003-10-01 00:00:00

  • Characterisation of intra-articular soft tissue tumours and tumour-like lesions.

    abstract::The aim of this study was to describe a new magnetic resonance imaging (MRI) classification system for intra-articular soft tissue tumours based on the morphology of the lesion, with the aim to aid the differential diagnosis. We performed a retrospective review of 52 consecutive patients presenting to a specialist mus...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Adams ME,Saifuddin A

    更新日期:2007-04-01 00:00:00

  • Speed of sound ultrasound: comparison with proton density fat fraction assessed with Dixon MRI for fat content quantification of the lower extremity.

    abstract:OBJECTIVES:To compare speed of sound (SoS) ultrasound (US) of the calves with Dixon magnetic resonance imaging (MRI) for fat content quantification. MATERIALS AND METHODS:The study was approved by the local ethics committee. Fifty calf muscles of 35 women (age range 22-81 years) prospectively underwent an US and subse...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Ruby L,Kunut A,Nakhostin DN,Huber FA,Finkenstaedt T,Frauenfelder T,Sanabria SJ,Rominger MB

    更新日期:2020-10-01 00:00:00

  • Quantitative CT detects progression in COPD patients with severe emphysema in a 3-month interval.

    abstract:OBJECTIVES:Chronic obstructive pulmonary disease (COPD) is characterized by variable contributions of emphysema and airway disease on computed tomography (CT), and still little is known on their temporal evolution. We hypothesized that quantitative CT (QCT) is able to detect short-time changes in a cohort of patients w...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Konietzke P,Wielpütz MO,Wagner WL,Wuennemann F,Kauczor HU,Heussel CP,Eichinger M,Eberhardt R,Gompelmann D,Weinheimer O

    更新日期:2020-05-01 00:00:00

  • Isolated cerebral susceptibility artefacts in patients with malignant melanoma: metastasis or not?

    abstract:OBJECTIVE:While staging patients with malignant melanoma, cerebral susceptibility artefacts on T2*-weighted/susceptibility-weighted imaging (SWI) sequences without a correlate on contrast-enhanced T1-weighted images can be confusing. Without intravenous contrast enhancement, cavernomas, microhaemorrhages and melanin-co...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Gramsch C,Göricke SL,Behrens F,Zimmer L,Schadendorf D,Krasny A,Forsting M,Schlamann MU

    更新日期:2013-09-01 00:00:00

  • CT perfusion imaging of the liver and the spleen in patients with cirrhosis: Is there a correlation between perfusion and portal venous hypertension?

    abstract:OBJECTIVES:To correlate hepatic and splenic CT perfusion parameters with hepatic venous pressure gradient (HVPG) measurements in patients with cirrhosis. METHODS:Twenty-one patients with cirrhosis (males, 17; females, 4; mean ± SD age, 57 ± 7 years) underwent hepatic and splenic perfusion CT on a 320-detector row volu...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Talakić E,Schaffellner S,Kniepeiss D,Mueller H,Stauber R,Quehenberger F,Schoellnast H

    更新日期:2017-10-01 00:00:00

  • Precise measurement of renal filtration and vascular parameters using a two-compartment model for dynamic contrast-enhanced MRI of the kidney gives realistic normal values.

    abstract:OBJECTIVE:To model the uptake phase of T(1)-weighted DCE-MRI data in normal kidneys and to demonstrate that the fitted physiological parameters correlate with published normal values. METHODS:The model incorporates delay and broadening of the arterial vascular peak as it appears in the capillary bed, two distinct comp...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Tofts PS,Cutajar M,Mendichovszky IA,Peters AM,Gordon I

    更新日期:2012-06-01 00:00:00

  • Delayed enhancement imaging of myocardial viability: low-dose high-pitch CT versus MRI.

    abstract:OBJECTIVES:To evaluate the accuracy of high-pitch delayed enhancement (DE) CT for the assessment of myocardial viability with MRI as the reference standard. METHODS:Twenty-four patients (mean age 66.9 ± 9.2 years) with coronary artery disease underwent DE imaging with 128-slice dual-source CT (prospective electrocardi...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Goetti R,Feuchtner G,Stolzmann P,Donati OF,Wieser M,Plass A,Frauenfelder T,Leschka S,Alkadhi H

    更新日期:2011-10-01 00:00:00

  • CT appearance of the larynx after conservative and radical surgery for carcinomas.

    abstract::The purpose of this study was to evaluate the normal CT appearance of the larynx after conservative and radical surgery. Postoperative (conservative surgery n = 52, radical surgery n = 21) CT examinations of 73 patients suspected of local/regional recurrence (n = 53) or asymptomatic (n = 20) were retrospectively analy...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Maroldi R,Battaglia G,Nicolai P,Maculotti P,Cappiello J,Cabassa P,Farina D,Chiesa A

    更新日期:1997-01-01 00:00:00

  • Hypoxia and perfusion in breast cancer: simultaneous assessment using PET/MR imaging.

    abstract:OBJECTIVES:Hypoxia is associated with poor prognosis and treatment resistance in breast cancer. However, the temporally variant nature of hypoxia can complicate interpretation of imaging findings. We explored the relationship between hypoxia and vascular function in breast tumours through combined 18F-fluoromisonidazol...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Carmona-Bozo JC,Manavaki R,Woitek R,Torheim T,Baxter GC,Caracò C,Provenzano E,Graves MJ,Fryer TD,Patterson AJ,Gilbert FJ

    更新日期:2021-01-01 00:00:00

  • Reproducibility of linear tumor measurements using PACS: comparison of caliper method with edge-tracing method.

    abstract::The aim of this study was to evaluate inter- and intra-observer reproducibility when making electronic caliper linear tumor measurements on picture archiving and communications systems (PACS) and compare them with linear measurements obtained from circumferential tracing of tumor perimeter. Three radiologists measured...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Monsky WL,Raptopoulos V,Keogan MT,Doty D,Kamel I,Yam CS,Ransil BJ

    更新日期:2004-03-01 00:00:00

  • Kinematic shoulder MRI: the diagnostic value in acute shoulder dislocations.

    abstract:OBJECTIVES:To determine whether positioning of the arm in adduction and internal rotation would improve the confidence in the diagnosis of Bankart lesions in first time shoulder dislocators. METHODS:Eleven patients were imaged on an open bore MRI within 1-6 days of traumatic shoulder dislocation with the arm adducted ...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Marcus M,Malhotra A,Peri M,Schweitzer M,Vladislav O,Tenebaum S,Shabshin N

    更新日期:2013-03-01 00:00:00

  • From community-acquired pneumonia to COVID-19: a deep learning-based method for quantitative analysis of COVID-19 on thick-section CT scans.

    abstract:OBJECTIVE:To develop a fully automated AI system to quantitatively assess the disease severity and disease progression of COVID-19 using thick-section chest CT images. METHODS:In this retrospective study, an AI system was developed to automatically segment and quantify the COVID-19-infected lung regions on thick-secti...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Li Z,Zhong Z,Li Y,Zhang T,Gao L,Jin D,Sun Y,Ye X,Yu L,Hu Z,Xiao J,Huang L,Tang Y

    更新日期:2020-12-01 00:00:00

  • Aneurysmal bone cyst of the cervical spine (2008:7b).

    abstract::Aneurysmal bone cysts (ABC) are rare, benign, but locally destructive bone tumors. They occur in the spine in 14% of cases, but only 2% are found in the cervical spine. This case report presents a 16-year-old female with an expansive aneurysmatic bone cyst with extensive bone destruction and instability in the cervica...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Pennekamp W,Peters S,Schinkel C,Kuhnen C,Nicolas V,Muhr G,Frangen TM

    更新日期:2008-10-01 00:00:00

  • White matter rather than gray matter damage characterizes essential tremor.

    abstract:OBJECTIVES:We investigated changes in gray matter (GM) and white matter (WM) in the whole brain, including both cortical and subcortical structures, and their relationship with tremor severity, psychiatric symptoms, and cognitive impairment in patients affected by essential tremor (ET). METHODS:We studied 19 ET patien...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Pietracupa S,Bologna M,Bharti K,Pasqua G,Tommasin S,Elifani F,Paparella G,Petsas N,Grillea G,Berardelli A,Pantano P

    更新日期:2019-12-01 00:00:00