Probability of malignancy for lesions detected on breast MRI: a predictive model incorporating BI-RADS imaging features and patient characteristics.


OBJECTIVES:To predict the probability of malignancy for MRI-detected breast lesions with a multivariate model incorporating patient and lesion characteristics. METHODS:Retrospective review of 2565 breast MR examinations from 1/03-11/06. BI-RADS 3, 4 and 5 lesions initially detected on MRI for new cancer or high-risk screening were included and outcomes determined by imaging, biopsy or tumor registry linkage. Variables were indication for MRI, age, lesion size, BI-RADS lesion type and kinetics. Associations with malignancy were assessed using generalized estimating equations and lesion probabilities of malignancy were calculated. RESULTS:855 lesions (155 malignant, 700 benign) were included. Strongest associations with malignancy were for kinetics (washout versus persistent; OR 4.2, 95% CI 2.5-7.1) and clinical indication (new cancer versus high-risk screening; OR 3.0, 95% CI 1.7-5.1). Also significant were age > = 50 years, size > = 10 mm and lesion-type mass. The most predictive model (AUC 0.70) incorporated indication, size and kinetics. The highest probability of malignancy (41.1%) was for lesions on MRI for new cancer, > = 10 mm with washout. The lowest (1.2%) was for lesions on high-risk screening, <10 mm with persistent kinetics. CONCLUSIONS:A multivariate model shows promise as a decision support tool in predicting malignancy for MRI-detected breast lesions.


Eur Radiol


European radiology


Demartini WB,Kurland BF,Gutierrez RL,Blackmore CC,Peacock S,Lehman CD




Has Abstract


2011-08-01 00:00:00












  • Iodine-based contrast media, multiple myeloma and monoclonal gammopathies: literature review and ESUR Contrast Media Safety Committee guidelines.

    abstract:OBJECTIVES:Many radiologists and clinicians still consider multiple myeloma (MM) and monoclonal gammopathies (MG) a contraindication for using iodine-based contrast media. The ESUR Contrast Media Safety Committee performed a systematic review of the incidence of post-contrast acute kidney injury (PC-AKI) in these patie...

    journal_title:European radiology

    pub_type: 杂志文章,评审


    authors: Stacul F,Bertolotto M,Thomsen HS,Pozzato G,Ugolini D,Bellin MF,Bongartz G,Clement O,Heinz-Peer G,van der Molen A,Reimer P,Webb JAW,ESUR Contrast Media Safety Committee.

    更新日期:2018-02-01 00:00:00

  • Correlation between the availability of dopamine transporter and olfactory function in healthy subjects.

    abstract:OBJECTIVES:Olfactory dysfunction in Parkinson's disease is usually prodromal to other symptoms. In this study, we aimed to explore the association of olfactory function with the availabilities of striatal dopamine transporter (DAT) in healthy subjects. METHODS:Data used in the preparation of this article were obtained...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Pak K,Kim K,Lee MJ,Lee JM,Kim BS,Kim SJ,Kim IJ

    更新日期:2018-04-01 00:00:00

  • Whole-body diffusion-weighted imaging: is it all we need for detecting metastases in melanoma patients?

    abstract:OBJECTIVES:To investigate whether whole-body diffusion-weighted imaging (WB-DWI) alone is adequate for detecting metastases in melanoma patients, or if standard WB contrast-enhanced magnetic resonance imaging (WB-ceMRI) is required. METHODS:Seventy-one WB-DWI studies were performed quarterly along with whole-body MRI ...

    journal_title:European radiology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Petralia G,Padhani A,Summers P,Alessi S,Raimondi S,Testori A,Bellomi M

    更新日期:2013-12-01 00:00:00

  • The value of re-staging chest CT at first local recurrence of extremity and trunk soft tissue sarcoma.

    abstract:OBJECTIVE:To determine the prevalence of pulmonary metastases on re-staging chest CT at the time of first local recurrence (LR) of trunk or extremity soft tissue sarcoma (STS). MATERIALS AND METHODS:Retrospective review of all patients diagnosed with recurrent STS between May 2007 and April 2018. Data collected includ...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Baig MS,Habib W,Attard V,Sharif B,Lindsay D,Upadhyay B,Saifuddin A

    更新日期:2020-10-10 00:00:00

  • Cardiac MRI in pulmonary artery hypertension: correlations between morphological and functional parameters and invasive measurements.

    abstract:OBJECTIVE:To compare cardiac MRI with right heart catheterisation in patients with pulmonary hypertension (PH) and to evaluate its ability to assess PH severity. MATERIALS AND METHODS:Forty patients were included. MRI included cine and phase-contrast sequences, study of ventricular function, cardiac cavity areas and r...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Alunni JP,Degano B,Arnaud C,Tétu L,Blot-Soulétie N,Didier A,Otal P,Rousseau H,Chabbert V

    更新日期:2010-05-01 00:00:00

  • MRI-CEST assessment of tumour perfusion using X-ray iodinated agents: comparison with a conventional Gd-based agent.

    abstract:OBJECTIVES:X-ray iodinated contrast media have been shown to generate contrast in MR images when used with the chemical exchange saturation transfer (CEST) approach. The aim of this study is to compare contrast enhancement (CE) capabilities and perfusion estimates between radiographic molecules and a Gd-based contrast ...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Anemone A,Consolino L,Longo DL

    更新日期:2017-05-01 00:00:00

  • Structural changes induced by antineoplastic therapies: keys to evaluate tumor response to treatment.

    abstract::The criteria to define therapeutic response in oncology are those proposed by Miller, characterized by four response categories (complete response, partial response, no change, progression of disease), and based upon both measurable and non-measurable (and otherwise assessable) morphological parameters in comparison w...

    journal_title:European radiology

    pub_type: 杂志文章,评审


    authors: Ferrozzi F,Tognini G,Pavone P

    更新日期:2002-04-01 00:00:00

  • Diagnostic performance of dual-energy contrast-enhanced subtracted mammography in dense breasts compared to mammography alone: interobserver blind-reading analysis.

    abstract:PURPOSE:To analyse the accuracy of dual-energy contrast-enhanced spectral mammography in dense breasts in comparison with contrast-enhanced subtracted mammography (CESM) and conventional mammography (Mx). MATERIALS AND METHODS:CESM cases of dense breasts with histological proof were evaluated in the present study. Fou...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Cheung YC,Lin YC,Wan YL,Yeow KM,Huang PC,Lo YF,Tsai HP,Ueng SH,Chang CJ

    更新日期:2014-10-01 00:00:00

  • Coronary artery lumen volume index as a marker of flow-limiting atherosclerosis-validation against 13N-ammonia positron emission tomography.

    abstract:OBJECTIVES:Coronary artery volume indexed to left myocardial mass (CAVi), derived from coronary computed tomography angiography (CCTA), has been proposed as an indicator of diffuse atherosclerosis. We investigated the association of CAVi with quantitative flow parameters and its ability to predict ischemia as derived f...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Benetos G,Benz DC,Rampidis GP,Giannopoulos AA,von Felten E,Bakula A,Sustar A,Fuchs TA,Pazhenkottil AP,Gebhard C,Kaufmann PA,Gräni C,Buechel RR

    更新日期:2021-01-16 00:00:00

  • Radiation dose management systems-requirements and recommendations for users from the ESR EuroSafe Imaging initiative.

    abstract::The European Directive 2013/59/Euratom requires member states of the European Union to ensure justification and optimisation of radiological procedures and store information on patient exposure for analysis and quality assurance. The EuroSafe Imaging campaign of the European Society of Radiology created a working grou...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Loose RW,Vano E,Mildenberger P,Tsapaki V,Caramella D,Sjöberg J,Paulo G,Torresin A,Schindera S,Frija G,Damilakis J,European Society of Radiology (ESR).

    更新日期:2020-09-21 00:00:00

  • Visualization of antigen-specific human cytotoxic T lymphocytes labeled with superparamagnetic iron-oxide particles.

    abstract::New technologies are needed to characterize the migration and survival of antigen-specific T cells in vivo. In this study, we developed a novel technique for the labeling of human cytotoxic T lymphocytes with superparamagnetic iron-oxide particles and the subsequent depiction with a conventional 1.5-T magnetic resonan...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Beer AJ,Holzapfel K,Neudorfer J,Piontek G,Settles M,Krönig H,Peschel C,Schlegel J,Rummeny EJ,Bernhard H

    更新日期:2008-06-01 00:00:00

  • Ablation of colorectal liver metastases by irreversible electroporation: results of the COLDFIRE-I ablate-and-resect study.

    abstract:OBJECTIVES:Irreversible electroporation (IRE) is a new ablation technique that relies on high-voltage electrical pulses. This clinical study evaluates the pathological response of colorectal liver metastases (CRLM) treated with IRE and the clinical safety and feasibility. METHODS:Ten patients with resectable CRLM were...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Scheffer HJ,Nielsen K,van Tilborg AA,Vieveen JM,Bouwman RA,Kazemier G,Niessen HW,Meijer S,van Kuijk C,van den Tol MP,Meijerink MR

    更新日期:2014-10-01 00:00:00

  • Fluid-fluid levels in bone neoplasms: variation of T1-weighted signal intensity of the superior to inferior layers--diagnostic significance on magnetic resonance imaging.

    abstract::The diagnostic relevance of the relative T1-weighted (T1W) and T2-weighted (T2W)/short tau inversion recovery (STIR) MRI signal intensity characteristics of the superior to inferior fluid layers within fluid-fluid levels (FFLs) found in bone tumours was investigated. A retrospective analysis was performed of MRI studi...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Alyas F,Saifuddin A

    更新日期:2008-11-01 00:00:00

  • Volume-assisted estimation of liver function based on Gd-EOB-DTPA-enhanced MR relaxometry.

    abstract:OBJECTIVES:To determine whether liver function as determined by indocyanine green (ICG) clearance can be estimated quantitatively from hepatic magnetic resonance (MR) relaxometry with gadoxetic acid (Gd-EOB-DTPA). METHODS:One hundred and seven patients underwent an ICG clearance test and Gd-EOB-DTPA-enhanced MRI, incl...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Haimerl M,Schlabeck M,Verloh N,Zeman F,Fellner C,Nickel D,Barreiros AP,Loss M,Stroszczynski C,Wiggermann P

    更新日期:2016-04-01 00:00:00

  • Pancreatic adenocarcinoma.

    abstract::Adenocarcinoma is the most common malignant pancreatic tumor, affecting the head of the pancreas in 60-70% of cases. By the time of diagnosis, at least 80% of tumors are unresectable. Helical computed tomography (CT) is very effective in detecting and staging adenocarcinoma, with a sensitivity of up to 90% for detecti...

    journal_title:European radiology

    pub_type: 杂志文章,评审


    authors: Schima W,Ba-Ssalamah A,Kölblinger C,Kulinna-Cosentini C,Puespoek A,Götzinger P

    更新日期:2007-03-01 00:00:00

  • The spectrum of tuberculosis and non-tuberculous mycobacterial infection.

    abstract::The spectrum of radiographic findings in pulmonary infections due to M. tuberculosis (TB) and non-tuberculous mycobacteria (NTM) are being increasingly discussed, primarily as a result of the increasing prevalence of these infections. The NTM organisms are often overlooked as potential infecting organisms, diagnosis i...

    journal_title:European radiology

    pub_type: 杂志文章,评审


    authors: Ellis SM

    更新日期:2004-03-01 00:00:00

  • Artificial intelligence for detecting small FDG-positive lung nodules in digital PET/CT: impact of image reconstructions on diagnostic performance.

    abstract:OBJECTIVES:To evaluate the diagnostic performance of a deep learning algorithm for automated detection of small 18F-FDG-avid pulmonary nodules in PET scans, and to assess whether novel block sequential regularized expectation maximization (BSREM) reconstruction affects detection accuracy as compared to ordered subset e...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Schwyzer M,Martini K,Benz DC,Burger IA,Ferraro DA,Kudura K,Treyer V,von Schulthess GK,Kaufmann PA,Huellner MW,Messerli M

    更新日期:2020-04-01 00:00:00

  • Percutaneous sclerotherapy of a symptomatic simple renal cyst in a child: observation of membrane detachment sign.

    abstract::A 6-year-old girl with a symptomatic renal cyst underwent successful percutaneous aspiration and sclerotherapy with hypertonic saline under US guidance. Although membrane detachment sign was seen clearly during aspiration, it was confirmed to be a simple cyst. In contrast to previous reports, membrane detachment sign ...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Kabaalioğlu A,Apaydin A,Ozkaynak C,Melikoğlu M,Sindel T,Lüleci E

    更新日期:1996-01-01 00:00:00

  • Quantitative assessment of mesorectal fat: new prognostic biomarker in patients with mid-to-lower rectal cancer.

    abstract:OBJECTIVES:To investigate the impact of mesorectal fat area (MFA) on oncologic outcomes in patients with mid-to-lower rectal cancer who received curative-intent surgery. METHODS:Patients with mid-to-lower rectal cancer who underwent preoperative abdominopelvic computed tomography (CT) and curative-intent surgery in 20...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Yoon J,Chung YE,Lim JS,Kim MJ

    更新日期:2019-03-01 00:00:00

  • Morphological measurements in computed tomography correlate with airflow obstruction in chronic obstructive pulmonary disease: systematic review and meta-analysis.

    abstract:OBJECTIVES:To determine the correlation between CT measurements of emphysema or peripheral airways and airflow obstruction in chronic obstructive pulmonary disease (COPD). METHODS:PubMed, Embase and Web of Knowledge were searched from 1976 to 2011. Two reviewers independently screened 1,763 citations to identify artic...

    journal_title:European radiology

    pub_type: 杂志文章,meta分析,评审


    authors: Xie X,de Jong PA,Oudkerk M,Wang Y,Ten Hacken NH,Miao J,Zhang G,de Bock GH,Vliegenthart R

    更新日期:2012-10-01 00:00:00

  • Multislice computed tomography perfusion imaging for visualization of acute pulmonary embolism: animal experience.

    abstract::The purpose of our animal study was to evaluate a new computed tomography (CT) subtraction technique for visualization of perfusion defects within the lung parenchyma in subsegmental pulmonary embolism (PE). Seven healthy pigs were entered into a prospective trial. Acute PE was artificially induced by fresh clot mater...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Wildberger JE,Klotz E,Ditt H,Spüntrup E,Mahnken AH,Günther RW

    更新日期:2005-07-01 00:00:00

  • Magnetic resonance imaging of pelvic floor dysfunction - joint recommendations of the ESUR and ESGAR Pelvic Floor Working Group.

    abstract:OBJECTIVE:To develop recommendations that can be used as guidance for standardized approach regarding indications, patient preparation, sequences acquisition, interpretation and reporting of magnetic resonance imaging (MRI) for diagnosis and grading of pelvic floor dysfunction (PFD). METHODS:The technique included cri...

    journal_title:European radiology

    pub_type: 共识发展会议,杂志文章


    authors: El Sayed RF,Alt CD,Maccioni F,Meissnitzer M,Masselli G,Manganaro L,Vinci V,Weishaupt D,ESUR and ESGAR Pelvic Floor Working Group.

    更新日期:2017-05-01 00:00:00

  • Speed of sound ultrasound: comparison with proton density fat fraction assessed with Dixon MRI for fat content quantification of the lower extremity.

    abstract:OBJECTIVES:To compare speed of sound (SoS) ultrasound (US) of the calves with Dixon magnetic resonance imaging (MRI) for fat content quantification. MATERIALS AND METHODS:The study was approved by the local ethics committee. Fifty calf muscles of 35 women (age range 22-81 years) prospectively underwent an US and subse...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Ruby L,Kunut A,Nakhostin DN,Huber FA,Finkenstaedt T,Frauenfelder T,Sanabria SJ,Rominger MB

    更新日期:2020-10-01 00:00:00

  • Multiparametric computer-aided differential diagnosis of Alzheimer's disease and frontotemporal dementia using structural and advanced MRI.

    abstract:OBJECTIVES:To investigate the added diagnostic value of arterial spin labelling (ASL) and diffusion tensor imaging (DTI) to structural MRI for computer-aided classification of Alzheimer's disease (AD), frontotemporal dementia (FTD), and controls. METHODS:This retrospective study used MRI data from 24 early-onset AD an...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Bron EE,Smits M,Papma JM,Steketee RME,Meijboom R,de Groot M,van Swieten JC,Niessen WJ,Klein S

    更新日期:2017-08-01 00:00:00

  • Implementation of eHealth and AI integrated diagnostics with multidisciplinary digitized data: are we ready from an international perspective?

    abstract::Digitization of medicine requires systematic handling of the increasing amount of health data to improve medical diagnosis. In this context, the integration of the versatile diagnostic information, e.g., from anamnesis, imaging, histopathology, and clinical chemistry, and its comprehensive analysis by artificial intel...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Bukowski M,Farkas R,Beyan O,Moll L,Hahn H,Kiessling F,Schmitz-Rode T

    更新日期:2020-10-01 00:00:00

  • Abbreviated MRI for HCC surveillance: is it ready for clinical use?

    abstract:KEY POINTS:• Abbreviated MRI (AMRI) protocols consist of acquiring only a minimal number of MRI sequences for HCC surveillance with acceptable diagnostic performance compared to complete MRI.• AMRI protocol options include non-contrast AMRI, dynamic AMRI or hepatobiliary phase AMRI post gadoxetate injection.• The best ...

    journal_title:European radiology

    pub_type: 社论


    authors: Vietti Violi N,Taouli B

    更新日期:2020-08-01 00:00:00

  • MR-guided vacuum-assisted breast biopsy of MRI-only lesions: a single center experience.

    abstract:PURPOSE:The purpose of this study was to compare three different biopsy devices on false-negative and underestimation rates in MR-guided, vacuum-assisted breast biopsy (VABB) of MRI-only lesions. METHODS:This retrospective, single-center study was IRB-approved. Informed consent was waived. 467 consecutive patients und...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Spick C,Schernthaner M,Pinker K,Kapetas P,Bernathova M,Polanec SH,Bickel H,Wengert GJ,Rudas M,Helbich TH,Baltzer PA

    更新日期:2016-11-01 00:00:00

  • Post-mortem computed tomography compared to forensic autopsy findings: a French experience.

    abstract:OBJECTIVES:The principal aim of our study was to establish concordance between post-mortem CT (PMCT) and forensic standard autopsy (SA) in detecting lesions according to different anatomical regions. A secondary aim was to determine the efficacy of PMCT in showing lethal lesions. METHODS:PMCTs were compared with autop...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Le Blanc-Louvry I,Thureau S,Duval C,Papin-Lefebvre F,Thiebot J,Dacher JN,Gricourt C,Touré E,Proust B

    更新日期:2013-07-01 00:00:00

  • The inhibitory effect of gadoxetate disodium on hepatic transporters: a study using indocyanine green.

    abstract:OBJECTIVES:To assess the inhibitory effect of gadoxetate disodium on the transporter system using indocyanine green (ICG). MATERIALS AND METHODS:Groups of six female B6 Albino mice were injected with the test agent (0.62 mmol/kg gadoxetate disodium) or phosphate-buffered saline (control) 10 min before injection of ICG...

    journal_title:European radiology

    pub_type: 杂志文章


    authors: Akai H,Yasaka K,Kunimatsu A,Nojima M,Inoue Y,Abe O,Ohtomo K,Kiryu S

    更新日期:2018-10-01 00:00:00

  • Impingement syndromes of the ankle.

    abstract::Ankle impingement syndromes are categorised according to their anatomical site around the tibiotalar joint. Anterolateral, anterior and posterior ankle impingement has been extensively described in the orthopaedic and radiology literature with more recent studies describing posteromedial and anteromedial impingement. ...

    journal_title:European radiology

    pub_type: 杂志文章,评审


    authors: Robinson P

    更新日期:2007-12-01 00:00:00