Abstract:
:Hepatobiliary contrast agents with uptake into hepatocytes followed by variable biliary excretion represent a unique class of cell-specific MR contrast agents. Two hepatobiliary contrast agents, mangafodipir trisodium and gadobenate dimeglumine, are already clinically approved. A third hepatobiliary contrast agent, Gd-EOB-DTPA, is under consideration. The purpose of this review is to provide an overview on the properties, clinical development and application of these three hepatobiliary contrast agents. Bolus injectable paramagnetic hepatobiliary contrast agents combine established features of extracellular agents with the advantages of hepatocyte specificity. The detection and characterisation of focal liver disease appears to be improved compared to unenhanced MRI, MRI with unspecific contrast agents and contrast-enhanced CT. To decrease the total time spent by a patient in the MR scanner, it is advisable to administer the agent immediately after acquisition of unenhanced T1-w MRI. After infusion or bolus injection (with dynamic FS-T1-w 2D or 3D GRE) of the contrast agent, moderately and heavily T2w images are acquired. Post-contrast T1-w MRI is started upon completion of T2-w MRI for mangafodipir trisodium and Gd-EOB-DTPA as early as 20 min following injection, while gadobenate dimeglumine scans are obtained >60 min following injection. Post-contrast acquisition techniques with near isotropic 3D pulse sequences with fat saturation parallel the technical progress made by MSCT combined with an unparalleled improvement in tumour-liver contrast. The individual decision that hepatobiliary contrast agent one uses is partly based on personal preferences. No comparative studies have been conducted comparing the advantages or disadvantages of all three agents directly against each other.
journal_name
Eur Radioljournal_title
European radiologyauthors
Reimer P,Schneider G,Schima Wdoi
10.1007/s00330-004-2236-1subject
Has Abstractpub_date
2004-04-01 00:00:00pages
559-78issue
4eissn
0938-7994issn
1432-1084journal_volume
14pub_type
杂志文章,评审abstract:INTRODUCTION:The aim of the study was to extract anthropometric measures from CT by deep learning and to evaluate their prognostic value in patients with non-small-cell lung cancer (NSCLC). METHODS:A convolutional neural network was trained to perform automatic segmentation of subcutaneous adipose tissue (SAT), viscer...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-019-06630-w
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVES:To compare the occurrence of transient severe motion (TSM) between gadoxetate disodium- and gadopentetate dimeglumine-enhanced MRI and between gadoxetate disodium-enhanced MRI scans obtained with and without the application of a modified breath-holding technique. METHODS:We reviewed 80 patients who underwen...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-5070-y
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:Magnetic resonance imaging (MRI) acquired on equipment capable of simultaneous MRI and positron emission tomography (PET) could potentially provide the gold standard method for motion correction of PET. To assess the latter, in this study we compared fast 2D and 3D MRI of the torso and used deformation param...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-011-2274-4
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVES:The aim of the present study was to histologically compare chondrotoxicity in surgically harvested intervertebral discs (IVDs) of patients following discoblock, discography, or no preoperative intervention. METHODS:Thirty patients (IVD degeneration Modic ≥ 2°, Pfirrmann 3° or 4°) at L4/5 or L5/S1 who were p...
journal_title:European radiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00330-016-4358-7
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Coronary angiography using multidetector computed tomography (MDCT) allows non-invasive assessment of non-calcified, calcified and mixed plaques. Progression of coronary plaques may be influenced by statins. METHODS:Sixty-three consecutive patients underwent MDCT as a follow-up to their original CT angiograp...
journal_title:European radiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00330-010-1880-x
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVES:To assess whether diffusion-weighted magnetic resonance imaging (DW-MRI) including bi-exponential fitting helps to detect residual/recurrent tumours after (chemo)radiotherapy of laryngeal and hypopharyngeal carcinoma. METHODS:Forty-six patients with newly-developed/worsening symptoms after (chemo)radiothera...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2596-x
更新日期:2013-02-01 00:00:00
abstract::A single center's procedural and follow-up results of radiological chest port placement in pediatric oncology patients are presented. Between July 2002 and December 2003, 37 children (20 boys, 17 girls; age range, 4 months to 16 years; mean 6.7 years) underwent chest port placement. All patients received only one port...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-004-2380-7
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:To investigate the intra- and inter-observer reliability and agreement between gray-scale and Doppler ultrasound (US) and contrast-enhanced ultrasound (CEUS) in measuring ablated volume (Va) after radiofrequency ablation (RFA) for benign thyroid nodules. METHODS:A total of 173 patients with 190 benign thyroi...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07398-0
更新日期:2020-10-31 00:00:00
abstract::We retrospectively reviewed surgical biopsy findings of lesions diagnosed as radial scars (RS) at stereotactic core-needle biopsy (SCNB). RS was diagnosed in 52 of 1415 (3.7%) consecutive mammographically detected lesions that underwent 14-gauge automated SCNB. Subsequent surgical biopsy findings were available for 43...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-006-0196-3
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVES:To review the gadoxetic acid disodium (EOB)-enhanced magnetic resonance (MR) imaging features of cholangiolocellular carcinoma (CoCC) of the liver and compare them with those of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). METHODS:EOB-enhanced MR images of 19 patients with CoCC,...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-4811-2
更新日期:2017-11-01 00:00:00
abstract::A 26-year-old woman presented with absence of the left lung. A diagnosis of pulmonary aplasia (main bronchus ending in a blind pouch) was established by bronchoscopy. Although a CT scan and MR imaging suggested the correct diagnosis, MR angiography enabled optimal demonstration of the vascular changes due to the anoma...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/BF00619968
更新日期:1996-01-01 00:00:00
abstract::In western European countries most blunt chest traumas are associated with motor vehicle and sport-related accidents. In Switzerland, 39 of 10,000 inhabitants were involved and severely injured in road accidents in 1998. Fifty two percent of them suffered from blunt chest trauma. According to the Swiss Federal Office ...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s003300000435
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to compare the coronary artery calcium score (CACS) and computed tomography coronary angiography (CTCA) for the assessment of non-obstructive/obstructive coronary artery disease (CAD) in high-risk asymptomatic subjects. METHODS:Two hundred and thirteen consecutive asymptomatic subje...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-009-1612-2
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVES:To compare the efficacy of ethanol ablation (EA) of cystic and predominantly cystic thyroid nodules, and to evaluate factors affecting efficacy. METHODS:From October 2008 to December 2010, a total of 217 thyroid nodules were treated with EA. Nodule volumes, symptoms and cosmetic scores were evaluated before...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2406-5
更新日期:2012-07-01 00:00:00
abstract::The aim of the study was to compare prospectively magnetic resonance cholangiography (MRC) and magnetic resonance imaging (MRI) with endoscopic retrograde cholangiography (ERC) in the diagnosis and staging of Klatskin tumours of the biliary tree (hilar cholangiocarcinomas). Forty-six patients with suspected Klatskin t...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-005-0139-4
更新日期:2006-10-01 00:00:00
abstract::Percutaneous thrombectomy (PT) is an established technique for the removal of acute thrombus in occluded arteries, veins and vascular grafts. Percutaneous thrombectomy can be used as an adjunctive treatment to other methods of thrombus removal such as thrombolysis or as sole therapy. The two main methods are percutane...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s003300101014
更新日期:2002-01-01 00:00:00
abstract::Psoas abscess is an uncommon condition and, contrary to traditional teaching, tends to be of non-tuberculous aetiology in developed countries. Diagnosis can be delayed since presenting features are non-specific and in many instances misleading, necessitating a high degree of clinical suspicion and early resort to cros...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300000661
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:Acoustic radiation force impulse (ARFI) imaging is an ultrasound-based elastography method that is integrated into a conventional ultrasound machine. A meta-analysis based on original and abstract publications was performed to evaluate the overall performance of ARFI for the diagnosis of liver fibrosis. MET...
journal_title:European radiology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00330-013-2927-6
更新日期:2013-11-01 00:00:00
abstract::Low motion phases for cardiac computed tomography reconstructions are currently detected manually in a user-dependent selection process which is often time consuming and suboptimal. The concept of motion maps was recently introduced to achieve automatic phase selection. This pilot study compared the accuracy of motion...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-005-2849-z
更新日期:2006-02-01 00:00:00
abstract::Accessory ossicles and sesamoid bones are frequent findings in routine radiographs of the ankle and foot. They are commonly considered fortuitous and unrelated to the patient's complaint; however, they may eventually cause painful syndromes or degenerative changes in response to overuse and trauma. They may also suffe...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-003-2011-8
更新日期:2003-12-01 00:00:00
abstract::Circumscribed radiolucencies within the vertebral bones can be due to a variety of changes including benign and malignant tumours or tumour-like lesions. Radiolucencies due to degenerative intraosseous pneumatocyst are very uncommon but have to be taken into the differential diagnosis in well-circumscribed lytic lesio...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300000490
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:To evaluate a pumping emulsification device that can improve the physiochemical properties and stability of lipiodol emulsion for conventional transarterial chemoembolization. MATERIALS AND METHODS:A pumping emulsification device constructed of a glass membrane with a hydrophobic surface with pore size of 50 μ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-5197-x
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:In dual-source CT, dual-energy (DE) performance is affected by various X-ray tube voltage combinations with and without tin filter (Sn). The purpose of this study was to assess the utility of the 80/150 Sn kV voltage combination in terms of image artefact and radiation dose for DECT gout protocol, compared w...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5622-9
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:To investigate the impact of an adaptive statistical iterative reconstruction (ASiR) algorithm on diagnostic accuracy and confidence for the diagnosis of hypervascular liver tumours, as well as the reader's perception of image quality, using a low tube voltage (80 kVp), high tube current computed tomography ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-2964-1
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:To determine the necessity of preprocedural biliary drainage prior to chemoembolisation for hepatocellular carcinoma (HCC) with bile duct invasion. MATERIALS AND METHODS:The study included 52 patients who received chemoembolisation for unresectable HCC invading bile duct and causing hyperbilirubinemia (>3 mg/d...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-5110-7
更新日期:2018-04-01 00:00:00
abstract::The purpose was to assess the diagnostic accuracy of a hand-held Doppler ultrasound (US) machine for the bedside detection of liver and vascular abnormalities after liver transplantation in the intensive care unit. The IRB approved this study, and written informed consent was obtained from all patients or the patient'...
journal_title:European radiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00330-009-1417-3
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVES:To evaluate factors associated with increased fluoroscopy time or the need for complex techniques at IVC filter retrieval. METHODS:This is a single-institution retrospective cohort study of 187 consecutive patients who underwent IVC filter retrieval. An analysis was performed on associations of patient fact...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5766-7
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the integrity of endometrial enhancement after magnetic resonance imaging-guided high-intensity focused ultrasound (MR-HIFU) ablation of submucosal uterine fibroids based on contrast-enhanced MRI findings, and to identify the risk factors for endometrial impairment. METHODS:In total, 117 submucos...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-4765-4
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to retrospectively assess the incidence of bowel wall oedema on computed tomography (CT) in patients with renal cell carcinoma (RCC) treated with sunitinib, and to investigate its association with diarrhoea. METHODS:We conducted a retrospective analysis of all RCC patients trea...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3389-1
更新日期:2015-02-01 00:00:00
abstract::The recent explosion of 'big data' has ushered in a new era of artificial intelligence (AI) algorithms in every sphere of technological activity, including medicine, and in particular radiology. However, the recent success of AI in certain flagship applications has, to some extent, masked decades-long advances in comp...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-018-5674-x
更新日期:2019-03-01 00:00:00