当前位置： SCI文献检索 > EUROPEAN RADIOLOGY期刊下所有文献 > Diffusion-weighted MR imaging including bi-exponential fitting for the detection of recurrent or residual tumour after (chemo)radiotherapy for laryngeal and hypopharyngeal cancers.

Diffusion-weighted MR imaging including bi-exponential fitting for the detection of recurrent or residual tumour after (chemo)radiotherapy for laryngeal and hypopharyngeal cancers.

Abstract：

OBJECTIVES:To assess whether diffusion-weighted magnetic resonance imaging (DW-MRI) including bi-exponential fitting helps to detect residual/recurrent tumours after (chemo)radiotherapy of laryngeal and hypopharyngeal carcinoma. METHODS:Forty-six patients with newly-developed/worsening symptoms after (chemo)radiotherapy for laryngeal/hypopharyngeal cancers were prospectively imaged using conventional MRI and axial DW-MRI. Qualitative (visual assessment) and quantitative analysis (mono-exponentially: total apparent diffusion coefficient [ADC(T)], and bi-exponentially: perfusion fraction [F(P)] and true diffusion coefficient [ADC(D)]) were performed. Diffusion parameters of tumour versus post-therapeutic changes were compared, with final diagnosis based on histopathology and follow-up. Mann-Whitney U test was used for statistical analysis. RESULTS:Qualitative DW-MRI combined with morphological images allowed the detection of tumour with a sensitivity of 94% and specificity 100%. ADC(T) and ADC(D) values were lower in tumour with values 120 ± 49 × 10(-5) mm(2)/s and 113 ± 50 × 10(-5) mm(2)/s, respectively, compared with post-therapeutic changes with values 182 ± 41 × 10(-5) mm(2)/s (P < 0.0002) and 160 ± 47 × 10(-5) mm(2)/s (P < 0.003), respectively. F(P) values were significantly lower in tumours than in non-tumours (13 ± 9% versus 31 ± 16%, P < 0.0002), with F(P) being the best quantitative parameter for differentiation between post-therapeutic changes and recurrence. CONCLUSIONS:DW-MRI in combination with conventional MRI substantially improves detection and exclusion of tumour in patients with laryngeal and hypopharyngeal cancers after treatment with (chemo)radiotherapy on both qualitative and quantitative analysis, with F(P) being the best quantitative parameter in this context.

journal_name

Eur Radiol

journal_title

European radiology

authors

Tshering Vogel DW,Zbaeren P,Geretschlaeger A,Vermathen P,De Keyzer F,Thoeny HC

doi

10.1007/s00330-012-2596-x

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

562-9

issue

eissn

0938-7994

issn

1432-1084

journal_volume

pub_type

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Diffusion-weighted MR imaging including bi-exponential fitting for the detection of recurrent or residual tumour after (chemo)radiotherapy for laryngeal and hypopharyngeal cancers.