A systematic review of the agreement between chronological age and skeletal age based on the Greulich and Pyle atlas.

Abstract:

OBJECTIVES:This systematic review examines the agreement between assessed skeletal age by the Greulich and Pyle atlas (GP skeletal age) and chronological age. METHODS:We searched electronic databases until January 2017 for studies reporting GP skeletal age and confirmed chronological age in healthy individuals aged 10-25 years. Results are presented as forest plots and meta-analyses (random-effects models). RESULTS:In separate meta-analyses for each age group and sex (14-18 years for girls, 14-19 years for boys), the pooled mean differences between GP skeletal age and chronological age varied from -0.52 years to 0.47 years. In individual studies, age group and sex-specific mean differences between GP skeletal age and chronological age rarely exceeded 1 year, but between-study heterogeneities were large in most age groups. Few studies examined mean chronological age and distribution for each GP skeletal age. One study of good methodological quality indicates that 95% prediction intervals for chronological age from given GP skeletal ages are typically around 4 years. CONCLUSIONS:There is still good correlation between GP skeletal age and mean chronological age in modern populations. However, the individual variation of development within a population and heterogeneities between studies are substantial. KEY POINTS:• The GP atlas still corresponds well with mean chronological age in modern populations. • The substantial variation within a population must be considered. • The heterogeneity between studies is relatively large and of unknown origin.

journal_name

Eur Radiol

journal_title

European radiology

authors

Dahlberg PS,Mosdøl A,Ding Y,Bleka Ø,Rolseth V,Straumann GH,Skjerven-Martinsen M,Delaveris GJM,Vist GE

doi

10.1007/s00330-018-5718-2

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

2936-2948

issue

6

eissn

0938-7994

issn

1432-1084

pii

10.1007/s00330-018-5718-2

journal_volume

29

pub_type

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