Abstract:
OBJECTIVES:To evaluate the association between tumour FDG uptake on preoperative PET/CT and axillary lymph node metastasis (ALNM) according to breast cancer subtype. METHODS:The records of 671 patients with invasive breast cancer who underwent (18) F-FDG PET/CT and surgery were reviewed. Using immunohistochemistry, tumours were divided into three subtypes: oestrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative, HER2-positive, and triple-negative. Tumour FDG uptake, expressed as maximum standardized uptake value (SUVmax), and clinicopathological variables were analysed. RESULTS:ALNM was present in 187 of 461 ER-positive/HER2-negative, 54 of 97 HER2-positive, and 38 of 113 triple-negative tumours. On multivariate analysis, high tumour SUVmax (≥4.25) (P < 0.001), large tumour size (>2 cm) (P = 0.003) and presence of lymphovascular invasion (P < 0.001) were independent variables associated with ALNM. On subset analyses, tumour SUVmax maintained independent significance for predicting ALNM in ER-positive/HER2-negative (adjusted odds ratio: 3.277, P < 0.001) and HER2-positive tumours (adjusted odds ratio: 14.637, P = 0.004). No association was found for triple-negative tumours (P = 0.161). CONCLUSIONS:Tumour SUVmax may be an independent prognostic factor for ALNM in patients with invasive breast cancer, especially in ER-positive/HER2-negative and HER2-positive subtypes, but not in those with triple-negative subtype. KEY POINTS:• Tumour SUVmax could be an imaging biomarker for predicting ALNM • Tumour SUVmax predicting ALNM is effective in ER-positive/HER2-negative and HER2-positive subtypes • Tumour SUVmax predicting ALNM is inaccurate in triple-negative subtypes • Accurate prognostic prediction based on molecular subtype may facilitate individualized management.
journal_name
Eur Radioljournal_title
European radiologyauthors
Kim JY,Lee SH,Kim S,Kang T,Bae YTdoi
10.1007/s00330-014-3452-ysubject
Has Abstractpub_date
2015-04-01 00:00:00pages
1172-81issue
4eissn
0938-7994issn
1432-1084journal_volume
25pub_type
杂志文章abstract:OBJECTIVES:Abdominal radiography is frequently used in acute abdominal non-traumatic pain despite the availability of more advanced diagnostic modalities. This study evaluates the diagnostic accuracy of low-dose CT compared with abdominal radiography, at similar radiation dose levels. METHODS:Fifty-eight patients were...
journal_title:European radiology
pub_type: 杂志文章,评审
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abstract:OBJECTIVES:To evaluate a new approach for reconstructing angiographic images by application of wavelet transforms on CT perfusion data. METHODS:Fifteen consecutive patients with suspected stroke were examined with a multi-detector CT acquiring 32 dynamic phases (∆t = 1.5s) of 99 slices (total slab thickness 99mm) at 8...
journal_title:European radiology
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journal_title:European radiology
pub_type: 评论,信件
doi:10.1007/s00330-012-2720-y
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abstract::We report a case of a 22-year-old male with Hunter syndrome who developed progressive major airway obstruction and was treated with insertion of plastic and metallic stents, with dramatic improvement in the patient's symptomatic and functional status. To the best of our knowledge, this is the first reported case of en...
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doi:10.1007/s003300100932
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abstract::Rapid clinical dissemination of CT colonography (CTC) is occurring in parallel with continued research into technique optimisation and diagnostic performance. A need exists therefore for current guidance as to basic prerequisites for effective clinical implementation. A questionnaire detailing CTC technique, analysis,...
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doi:10.1007/s00330-006-0407-y
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journal_title:European radiology
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journal_title:European radiology
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doi:10.1007/s00330-012-2385-6
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journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-004-2441-y
更新日期:2004-11-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00330-016-4598-6
更新日期:2017-06-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-010-1862-z
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVES:To evaluate the agreement between automated breast volume scanner (ABVS) and conventional ultrasound (US) as a second-look (SL) tool for assessing additional findings found on MRI. METHODS:Over a 7-month period, we prospectively assigned to SL-US and SL-ABVS all patients undergoing 1.5 T breast MRI in whom ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-4749-4
更新日期:2017-09-01 00:00:00
abstract::The objective of this study was to optimize ankle joint MR imaging in volunteers at 1.5 Tesla (T) and 3.0 T, and to compare these optimized sequences concerning image quality and performance in assessing cartilage, ligament and tendon pathology in fresh human cadaver specimens. Initially our clinical ankle protocol co...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-006-0446-4
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the relationship between multiple MR perfusion parameters and symptoms of patients with osteoid osteomas after percutaneous laser therapy. METHODS:MR perfusion studies of 20 patients diagnosed with an osteoid osteoma, treated with CT-guided percutaneous laser therapy, were retrospectively evaluat...
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pub_type: 杂志文章
doi:10.1007/s00330-013-2867-1
更新日期:2013-09-01 00:00:00
abstract::To assess the practical feasibility and effectiveness of real-time magnetic resonance (MR) temperature monitoring for the radiofrequency (RF) ablation of liver tumours in a clinical setting, nine patients (aged 49-87 years, five men and four women) with one malignant tumour (14-50 mm, eight hepatocellular carcinomas a...
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pub_type: 杂志文章
doi:10.1007/s00330-009-1532-1
更新日期:2010-01-01 00:00:00
abstract::The aim of this study was to analyze the precision of tibial cartilage morphometry, by using a fast, coronal water-excitation sequence with high spatial resolution, to compare the reproducibility of 3D thickness vs volume estimates, and to test the technique in patients with severe osteoarthritis. The tibiae of 8 heal...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050047
更新日期:2000-01-01 00:00:00
abstract::The aim of this study was to develop an endorectal MRI strategy for prostatic cancer. We evaluated the MR images from 44 consecutive prostatic cancer patients treated by radical prostatectomy. Each sequence from every examination was assessed separately with a specific tumor map drawn. Tumor localization, capsular pen...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300000598
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:To investigate how normal liver parenchyma visibility on 3 T diffusion-weighted images (DWI) and apparent diffusion coefficient (ADC) quantification are influenced by age, gender, and iron content. METHODS:Between February 2011 and April 2013, 86 patients (52 women) with normal livers who underwent respirat...
journal_title:European radiology
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doi:10.1007/s00330-014-3353-0
更新日期:2014-12-01 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:European radiology
pub_type: 临床试验,杂志文章
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journal_title:European radiology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European radiology
pub_type: 杂志文章
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更新日期:2003-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07016-z
更新日期:2020-12-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
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更新日期:2019-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00330-020-07649-0
更新日期:2021-01-15 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-05-01 00:00:00