11C-harmine as a potential PET tracer for ductal pancreas cancer: in vitro studies.

Abstract:

:Our objective was to find a tracer in diagnosing human pancreatic cancer using positron emission tomography (PET). For this purpose in vitro test of pancreatic tissues with autoradiography was used. Autoradiography was performed with (11)C-harmine (a MAO-A-inhibitor) with and without competitive inhibition. Tissue preparations were obtained from normal human pancreas and pancreatic cancer. The uptake was compared with rat brain or pig brain, tissues with high expression of MAO-A. Nine autoradiography studies on 16 samples from five different human pancreatic cancers gave a significant level of specific binding of (11)C-harmine in 13, and 3 samples did not give a significant level of specific binding of (11)C-harmine. All 16 samples were analysed with autoradiography. Compared with rat brain, the uptake in the human cancers varied between 9 and 43% except for one tissue preparation which had a too low value for measurement. This study shows expression of MAO-A in human pancreatic cancer. This is readily characterised in vitro. The potential use of (11)C-harmine in the diagnosis of pancreatic cancer using PET might be limited, but further PET studies are necessary.

journal_name

Eur Radiol

journal_title

European radiology

authors

Herlin G,Persson B,Bergström M,Långström B,Aspelin P

doi

10.1007/s00330-002-1443-x

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

729-33

issue

4

eissn

0938-7994

issn

1432-1084

journal_volume

13

pub_type

杂志文章
  • An open source toolkit for medical imaging de-identification.

    abstract:OBJECTIVE:Medical imaging acquired for clinical purposes can have several legitimate secondary uses in research projects and teaching libraries. No commonly accepted solution for anonymising these images exists because the amount of personal data that should be preserved varies case by case. Our objective is to provide...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-010-1745-3

    authors: González DR,Carpenter T,van Hemert JI,Wardlaw J

    更新日期:2010-08-01 00:00:00

  • Dose reduction in CT examination of children by an attenuation-based on-line modulation of tube current (CARE Dose).

    abstract::In a controlled patient study we investigated the potential of attenuation-based on-line modulation of the tube current to reduce milliampere values (mAs) in CT examinations of children without loss of image quality. mAs can be reduced for non-circular patient cross sections without an increase in noise if tube curren...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-001-1255-4

    authors: Greess H,Nömayr A,Wolf H,Baum U,Lell M,Böwing B,Kalender W,Bautz WA

    更新日期:2002-06-01 00:00:00

  • Late aneurysm formation in a femoro-popliteal polytetrafluoroethylene graft.

    abstract::Since improvement in the material, true aneurysms and pseudoaneurysm formations have become relatively rare complications after femoro-popliteal reconstruction with polytetrafluoroethylene (PTFE) grafts. We report a case of late graft rupture and pseudoaneurysm formation within the straight femoral part of a femoro-po...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s003300050909

    authors: Biederer J,Müller-Hülsbeck S,Loose JR,Heller M

    更新日期:1999-01-01 00:00:00

  • Gadoxetic acid disodium-enhanced MR imaging of cholangiolocellular carcinoma of the liver: imaging characteristics and histopathological correlations.

    abstract:OBJECTIVES:To review the gadoxetic acid disodium (EOB)-enhanced magnetic resonance (MR) imaging features of cholangiolocellular carcinoma (CoCC) of the liver and compare them with those of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). METHODS:EOB-enhanced MR images of 19 patients with CoCC,...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-017-4811-2

    authors: Haradome H,Unno T,Morisaka H,Toda Y,Kwee TC,Kondo H,Sano K,Ichikawa T,Kondo F,Sugitani M,Takayama T

    更新日期:2017-11-01 00:00:00

  • Quantitating aortic regurgitation by cardiovascular magnetic resonance: significant variations due to slice location and breath holding.

    abstract:OBJECTIVES:Compare variability in flow measurements by phase contrast MRI, performed at different locations in the aorta and pulmonary artery (PA) using breath-held (BH) and free-breathing (FB) sequences. METHODS:Fifty-seven patients with valvular heart disease, confirmed by echocardiography, were scanned using BH tec...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-015-4120-6

    authors: Chaturvedi A,Hamilton-Craig C,Cawley PJ,Mitsumori LM,Otto CM,Maki JH

    更新日期:2016-09-01 00:00:00

  • Digital radiography.Results of a survey (part A) and a consensus conference (part B)

    abstract::Digital imaging (digital image intensifier radiography, storage phosphor/selenium radiography) is increasingly becoming commonplace in radiology departments for diagnostic purposes. Despite 10 years of experience, the advantages and disadvantages of those methods are still heavily discussed among users, financiers and...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:

    authors: Braunschweig R,Klose HJ,Neugebauer E,Busch HP

    更新日期:1997-02-21 00:00:00

  • Scan and contrast administration principles of MDCT.

    abstract::Because of its fast scan speed, multi-detector row CT (MDCT) imposes a challenge to optimization of contrast enhancement and scan timing. However, when this challenge is overcome with the use of precisely designed protocols, MDCT provides us with an opportunity to use contrast medium more efficiently and flexibly than...

    journal_title:European radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s10406-005-0165-y

    authors: Bae KT,Heiken JP

    更新日期:2005-12-01 00:00:00

  • The "solid" component within subsolid nodules: imaging definition, display, and correlation with invasiveness of lung adenocarcinoma, a comparison of CT histograms and subjective evaluation.

    abstract:OBJECTIVE:To validate three proposed definitions of the "solid" component of subsolid nodules, as compared to CT histograms and the use of different window settings, for discriminating the invasiveness of adenocarcinomas in a manner that facilitates routine clinical assessment. METHODS:We retrospectively analyzed 328 ...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-018-5778-3

    authors: Tu W,Li Z,Wang Y,Li Q,Xia Y,Guan Y,Xiao Y,Fan L,Liu S

    更新日期:2019-04-01 00:00:00

  • Subcentimeter hypervascular nodules with typical imaging findings of hepatocellular carcinoma on gadoxetic acid-enhanced MRI: Outcomes of early treatment and watchful waiting.

    abstract:OBJECTIVES:To compare treatment outcomes of subcentimeter hypervascular nodules at high risk for developing into hepatocellular carcinomas (SHNHR) between early treatment and watchful waiting until progression to overt hepatocellular carcinoma (HCC) groups. METHODS:SHNHRs were defined as subcentimeter hypervascular no...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-017-4818-8

    authors: Woo JH,Song KD,Kim SH

    更新日期:2017-10-01 00:00:00

  • Secondary aortoenteric fistula: active bleeding detected with multi-detector-row CT.

    abstract::We report a case of active bleeding of a secondary aortoenteric fistula (SAEF), in which CT angiography with multi-detector-row CT (MDCT) was finally diagnostic after negative catheter angiography and unsatisfactory endoscopy. The MDCT angiography clearly demonstrated the fistulous tract between the abdominal aortic g...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-002-1534-8

    authors: Roos JE,Willmann JK,Hilfiker PR

    更新日期:2002-12-01 00:00:00

  • The second ESGAR consensus statement on CT colonography.

    abstract:OBJECTIVE:To update quality standards for CT colonography based on consensus among opinion leaders within the European Society of Gastrointestinal and Abdominal Radiology (ESGAR). MATERIAL AND METHODS:A multinational European panel of nine members of the ESGAR CT colonography Working Group (representing six EU countri...

    journal_title:European radiology

    pub_type: 杂志文章,实务指引

    doi:10.1007/s00330-012-2632-x

    authors: Neri E,Halligan S,Hellström M,Lefere P,Mang T,Regge D,Stoker J,Taylor S,Laghi A,ESGAR CT Colonography Working Group.

    更新日期:2013-03-01 00:00:00

  • Cystic versus predominantly cystic thyroid nodules: efficacy of ethanol ablation and analysis of related factors.

    abstract:OBJECTIVES:To compare the efficacy of ethanol ablation (EA) of cystic and predominantly cystic thyroid nodules, and to evaluate factors affecting efficacy. METHODS:From October 2008 to December 2010, a total of 217 thyroid nodules were treated with EA. Nodule volumes, symptoms and cosmetic scores were evaluated before...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-012-2406-5

    authors: Kim YJ,Baek JH,Ha EJ,Lim HK,Lee JH,Sung JY,Kim JK,Kim TY,Kim WB,Shong YK

    更新日期:2012-07-01 00:00:00

  • A simple classification system (the Tree flowchart) for breast MRI can reduce the number of unnecessary biopsies in MRI-only lesions.

    abstract:OBJECTIVES:To assess whether using the Tree flowchart obviates unnecessary magnetic resonance imaging (MRI)-guided biopsies in breast lesions only visible on MRI. METHODS:This retrospective IRB-approved study evaluated consecutive suspicious (BI-RADS 4) breast lesions only visible on MRI that were referred to our inst...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-017-4755-6

    authors: Woitek R,Spick C,Schernthaner M,Rudas M,Kapetas P,Bernathova M,Furtner J,Pinker K,Helbich TH,Baltzer PAT

    更新日期:2017-09-01 00:00:00

  • Causes, clinical features and non-operative management of bile leaks.

    abstract::This paper evaluates the management of 31 patients with bile leaks identified over a 7-year period. Leaks complicated cholecystectomy in 19 patients (11 laparoscopic, 8 open), interventional procedures in 10 (including surgery in 1), trauma in one and was spontaneous in one case. Confirmation of the diagnosis typicall...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s003300050595

    authors: McLindon JP,England RE,Martin DF

    更新日期:1998-01-01 00:00:00

  • Hypoxia and perfusion in breast cancer: simultaneous assessment using PET/MR imaging.

    abstract:OBJECTIVES:Hypoxia is associated with poor prognosis and treatment resistance in breast cancer. However, the temporally variant nature of hypoxia can complicate interpretation of imaging findings. We explored the relationship between hypoxia and vascular function in breast tumours through combined 18F-fluoromisonidazol...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-020-07067-2

    authors: Carmona-Bozo JC,Manavaki R,Woitek R,Torheim T,Baxter GC,Caracò C,Provenzano E,Graves MJ,Fryer TD,Patterson AJ,Gilbert FJ

    更新日期:2021-01-01 00:00:00

  • Ethanolgel sclerotherapy of venous malformations improves health-related quality-of-life in adults and children - results of a prospective study.

    abstract:OBJECTIVES:To assess the treatment-induced changes of health-related quality-of-life (HRQoL) in patients with venous malformations (VM) who underwent ethanol gel sclerotherapy. METHODS:The prospective study in children and adults was approved by the local ethics committee. 31 patients (mean age 23.42 years, range 6.6 ...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-016-4603-0

    authors: Wohlgemuth WA,Müller-Wille R,Teusch V,Hammer S,Wildgruber M,Uller W

    更新日期:2017-06-01 00:00:00

  • MR arthrography of the hip: normal intra-articular structures and common disorders.

    abstract::This pictorial review illustrates the anatomical features of normal intra-articular components of the hip and their common disorders on MR arthrography. On T1-weighted MR arthrograms, the normal contrast-filled joint cavity shows a homogeneous high signal intensity. Normal acetabular labrum appears as a well-delineate...

    journal_title:European radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s003300050009

    authors: Ghebontni L,Roger B,El-khoury J,Brasseur JL,Grenier PA

    更新日期:2000-01-01 00:00:00

  • Magnetic resonance imaging of pelvic floor dysfunction - joint recommendations of the ESUR and ESGAR Pelvic Floor Working Group.

    abstract:OBJECTIVE:To develop recommendations that can be used as guidance for standardized approach regarding indications, patient preparation, sequences acquisition, interpretation and reporting of magnetic resonance imaging (MRI) for diagnosis and grading of pelvic floor dysfunction (PFD). METHODS:The technique included cri...

    journal_title:European radiology

    pub_type: 共识发展会议,杂志文章

    doi:10.1007/s00330-016-4471-7

    authors: El Sayed RF,Alt CD,Maccioni F,Meissnitzer M,Masselli G,Manganaro L,Vinci V,Weishaupt D,ESUR and ESGAR Pelvic Floor Working Group.

    更新日期:2017-05-01 00:00:00

  • Optimized intravenous Flat Detector CT for non-invasive visualization of intracranial stents: first results.

    abstract:OBJECTIVE:As stents for treating intracranial atherosclerotic stenosis may develop in-stent re-stenosis (ISR) in up to 30%, follow-up imaging is mandatory. Residual stenosis (RS) is not rare. We evaluated an optimised Flat Detector CT protocol with intravenous contrast material application (i.v. FD-CTA) for non-invasiv...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-010-1931-3

    authors: Struffert T,Kloska S,Engelhorn T,Deuerling-Zheng Y,Ott S,Doelken M,Saake M,Köhrmann M,Doerfler A

    更新日期:2011-02-01 00:00:00

  • Performing MR-guided biopsies in clinical routine: factors that influence accuracy and procedure time.

    abstract:OBJECTIVE:To assess the accuracy, the duration and factors that influence the duration of MRI-guided liver or soft-tissue biopsies. METHODS:Nineteen liver biopsies and 19 soft-tissue biopsies performed using 1.5T-MRI guidance were retrospectively analysed. Diagnostic performance and complications were assessed. Interv...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-011-2297-x

    authors: Hoffmann R,Thomas C,Rempp H,Schmidt D,Pereira PL,Claussen CD,Clasen S

    更新日期:2012-03-01 00:00:00

  • Structural changes induced by antineoplastic therapies: keys to evaluate tumor response to treatment.

    abstract::The criteria to define therapeutic response in oncology are those proposed by Miller, characterized by four response categories (complete response, partial response, no change, progression of disease), and based upon both measurable and non-measurable (and otherwise assessable) morphological parameters in comparison w...

    journal_title:European radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s003300101074

    authors: Ferrozzi F,Tognini G,Pavone P

    更新日期:2002-04-01 00:00:00

  • Hyperintense globus pallidus on T1-weighted MR imaging in acute kernicterus: is it common or rare?

    abstract::Globus pallidus involvement is a well-known magnetic resonance (MR) imaging finding of acute kernicterus. However, it is not clear how early the involvement of globus pallidus occurs and whether or not it is seen in every case. Therefore, we aimed to investigate the globus pallidus involvement in 13 neonates with acut...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-004-2502-2

    authors: Coskun A,Yikilmaz A,Kumandas S,Karahan OI,Akcakus M,Manav A

    更新日期:2005-06-01 00:00:00

  • Sclerosing lobular hyperplasia: sonographic pathologic correlation.

    abstract::The objective was to evaluate the sonographic findings of sclerosing lobular hyperplasia (SLH) of the breast and to correlate the sonographic findings and the pathologic features. This study consisted of 9 patients with pathologically proven sclerosing lobular hyperplasia who had undergone a preoperative imaging study...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-002-1732-4

    authors: Cho N,Oh KK,Park KY,Noh TW

    更新日期:2003-07-01 00:00:00

  • The prevalence and significance of renal perfusion defects in early kidney transplants quantified using 3D contrast enhanced ultrasound (CEUS).

    abstract:OBJECTIVES:Vascular complications are one of the most common causes of early kidney transplant dysfunction. Contrast enhanced ultrasound increases sensitivity to vascular changes. The aim of this study was to assess the prevalence and size of vascular abnormalities in early renal transplants using 3D CEUS and the signi...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-017-4871-3

    authors: Stenberg B,Wilkinson M,Elliott S,Caplan N

    更新日期:2017-11-01 00:00:00

  • Impact of post-processing methods on apparent diffusion coefficient values.

    abstract:OBJECTIVE:The apparent diffusion coefficient (ADC) is increasingly used as a quantitative biomarker in oncological imaging. ADC calculation is based on raw diffusion-weighted imaging (DWI) data, and multiple post-processing methods (PPMs) have been proposed for this purpose. We investigated whether PPM has an impact on...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-016-4403-6

    authors: Zeilinger MG,Lell M,Baltzer PA,Dörfler A,Uder M,Dietzel M

    更新日期:2017-03-01 00:00:00

  • MRI investigation of normal fetal lung maturation using signal intensities on different imaging sequences.

    abstract::To purpose of this paper is to study the relation between normal lung maturation signal and changes in intensity ratios (SIR) and to determine which magnetic resonance imaging sequence provides the strongest correlation of normal lung SIs with gestational age. 126 normal singleton pregnancies (20-37 weeks) were examin...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-006-0409-9

    authors: Balassy C,Kasprian G,Brugger PC,Weber M,Csapo B,Mittermayer C,Hörmann M,Prayer D

    更新日期:2007-03-01 00:00:00

  • Morphological, functional and metabolic imaging biomarkers: assessment of vascular-disrupting effect on rodent liver tumours.

    abstract:OBJECTIVES:To evaluate effects of a vascular-disrupting agent on rodent tumour models. METHODS:Twenty rats with liver rhabdomyosarcomas received ZD6126 intravenously at 20 mg/kg, and 10 vehicle-treated rats were used as controls. Multiple sequences, including diffusion-weighted imaging (DWI) and dynamic contrast-enhan...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-010-1743-5

    authors: Wang H,Li J,Chen F,De Keyzer F,Yu J,Feng Y,Nuyts J,Marchal G,Ni Y

    更新日期:2010-08-01 00:00:00

  • Dual-Phase Dual-Energy CT in Patients Treated with Erlotinib for Advanced Non-Small Cell Lung Cancer: Possible Benefits of Iodine Quantification in Response Assessment.

    abstract:OBJECTIVES:To investigate the relationship of dual-phase dual-energy CT (DE-CT) and tumour size in the evaluation of the response to anti-EGFR therapy in patients with advanced non-small cell lung cancer (NSCLC). METHODS:Dual-phase DE-CT was performed in 31 patients with NSCLC before the onset of anti-EGFR (erlotinib)...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-015-4092-6

    authors: Baxa J,Matouskova T,Krakorova G,Schmidt B,Flohr T,Sedlmair M,Bejcek J,Ferda J

    更新日期:2016-08-01 00:00:00

  • Diffuse metastatic infiltration of a carcinoma into skeletal muscle.

    abstract::Skeletal muscle is one of the most unusual sites of metastasis from any malignancy. We report a patient with rapidly progressive contractures due to metastatic infiltration of a carcinoma of unknown origin into the skeletal muscle. This 61-year-old man presented with a 1-month history of rapidly evolving, painful rest...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s003300050657

    authors: Hundt W,Braunschweig R,Reiser M

    更新日期:1999-01-01 00:00:00

  • Solitary solid pulmonary nodules: a CT-based deep learning nomogram helps differentiate tuberculosis granulomas from lung adenocarcinomas.

    abstract:OBJECTIVES:To evaluate the differential diagnostic performance of a computed tomography (CT)-based deep learning nomogram (DLN) in identifying tuberculous granuloma (TBG) and lung adenocarcinoma (LAC) presenting as solitary solid pulmonary nodules (SSPNs). METHODS:Routine CT images of 550 patients with SSPNs were retr...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-020-07024-z

    authors: Feng B,Chen X,Chen Y,Lu S,Liu K,Li K,Liu Z,Hao Y,Li Z,Zhu Z,Yao N,Liang G,Zhang J,Long W,Liu X

    更新日期:2020-12-01 00:00:00