Abstract:
:Our objective was to find a tracer in diagnosing human pancreatic cancer using positron emission tomography (PET). For this purpose in vitro test of pancreatic tissues with autoradiography was used. Autoradiography was performed with (11)C-harmine (a MAO-A-inhibitor) with and without competitive inhibition. Tissue preparations were obtained from normal human pancreas and pancreatic cancer. The uptake was compared with rat brain or pig brain, tissues with high expression of MAO-A. Nine autoradiography studies on 16 samples from five different human pancreatic cancers gave a significant level of specific binding of (11)C-harmine in 13, and 3 samples did not give a significant level of specific binding of (11)C-harmine. All 16 samples were analysed with autoradiography. Compared with rat brain, the uptake in the human cancers varied between 9 and 43% except for one tissue preparation which had a too low value for measurement. This study shows expression of MAO-A in human pancreatic cancer. This is readily characterised in vitro. The potential use of (11)C-harmine in the diagnosis of pancreatic cancer using PET might be limited, but further PET studies are necessary.
journal_name
Eur Radioljournal_title
European radiologyauthors
Herlin G,Persson B,Bergström M,Långström B,Aspelin Pdoi
10.1007/s00330-002-1443-xsubject
Has Abstractpub_date
2003-04-01 00:00:00pages
729-33issue
4eissn
0938-7994issn
1432-1084journal_volume
13pub_type
杂志文章abstract:OBJECTIVE:Medical imaging acquired for clinical purposes can have several legitimate secondary uses in research projects and teaching libraries. No commonly accepted solution for anonymising these images exists because the amount of personal data that should be preserved varies case by case. Our objective is to provide...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-010-1745-3
更新日期:2010-08-01 00:00:00
abstract::In a controlled patient study we investigated the potential of attenuation-based on-line modulation of the tube current to reduce milliampere values (mAs) in CT examinations of children without loss of image quality. mAs can be reduced for non-circular patient cross sections without an increase in noise if tube curren...
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journal_title:European radiology
pub_type: 杂志文章
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更新日期:2017-11-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-4120-6
更新日期:2016-09-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:
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pub_type: 杂志文章,评审
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更新日期:2005-12-01 00:00:00
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更新日期:2019-04-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-4818-8
更新日期:2017-10-01 00:00:00
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doi:10.1007/s00330-002-1534-8
更新日期:2002-12-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章,实务指引
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更新日期:2013-03-01 00:00:00
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doi:10.1007/s00330-012-2406-5
更新日期:2012-07-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-4755-6
更新日期:2017-09-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050595
更新日期:1998-01-01 00:00:00
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doi:10.1007/s00330-020-07067-2
更新日期:2021-01-01 00:00:00
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doi:10.1007/s00330-016-4603-0
更新日期:2017-06-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s003300050009
更新日期:2000-01-01 00:00:00
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pub_type: 共识发展会议,杂志文章
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更新日期:2017-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00330-010-1931-3
更新日期:2011-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-03-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s003300101074
更新日期:2002-04-01 00:00:00
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更新日期:2005-06-01 00:00:00
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更新日期:2003-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00330-017-4871-3
更新日期:2017-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00330-016-4403-6
更新日期:2017-03-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-006-0409-9
更新日期:2007-03-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-010-1743-5
更新日期:2010-08-01 00:00:00
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doi:10.1007/s00330-015-4092-6
更新日期:2016-08-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050657
更新日期:1999-01-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07024-z
更新日期:2020-12-01 00:00:00