Abstract:
OBJECTIVES:To evaluate effects of a vascular-disrupting agent on rodent tumour models. METHODS:Twenty rats with liver rhabdomyosarcomas received ZD6126 intravenously at 20 mg/kg, and 10 vehicle-treated rats were used as controls. Multiple sequences, including diffusion-weighted imaging (DWI) and dynamic contrast-enhanced MRI (DCE-MRI) with the microvascular permeability constant (K), were acquired at baseline, 1 h, 24 h and 48 h post-treatment by using 1.5-T MRI. [(18)F]fluorodeoxyglucose micro-positron emission tomography ((18)F-FDG microPET) was acquired pre- and post-treatment. The imaging biomarkers including tumour volume, enhancement ratio, necrosis ratio, apparent diffusion coefficient (ADC) and K from MRI, and maximal standardised uptake value (SUV(max)) from FDG microPET were quantified and correlated with postmortem microangiography and histopathology. RESULTS:In the ZD6126-treated group, tumours grew slower with higher necrosis ratio at 48 h (P < 0.05), corresponding well to histopathology; tumour K decreased from 1 h until 24 h, and partially recovered at 48 h (P < 0.05), parallel to the evolving enhancement ratios (P < 0.05); ADCs varied with tumour viability and perfusion; and SUV(max) dropped at 24 h (P < 0.01). Relative K of tumour versus liver at 48 h correlated with relative vascular density on microangiography (r = 0.93, P < 0.05). CONCLUSIONS:The imaging biomarkers allowed morphological, functional and metabolic quantifications of vascular shutdown, necrosis formation and tumour relapse shortly after treatment. A single dose of ZD6126 significantly diminished tumour blood supply and growth until 48 h post-treatment.
journal_name
Eur Radioljournal_title
European radiologyauthors
Wang H,Li J,Chen F,De Keyzer F,Yu J,Feng Y,Nuyts J,Marchal G,Ni Ydoi
10.1007/s00330-010-1743-5subject
Has Abstractpub_date
2010-08-01 00:00:00pages
2013-26issue
8eissn
0938-7994issn
1432-1084journal_volume
20pub_type
杂志文章abstract::Endovascular treatment options for visceral artery pseudoaneurysms depend on lesion location and size. Exclusion methods fall into two categories, embolization and stent placement, and these procedures aim to exclude the pseudoaneurysm from the circulation and if possible to maintain distal blood flow. Embolization of...
journal_title:European radiology
pub_type: 杂志文章
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journal_title:European radiology
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journal_title:European radiology
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journal_title:European radiology
pub_type: 杂志文章,多中心研究
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journal_title:European radiology
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更新日期:2016-08-01 00:00:00
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更新日期:2002-11-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2019-06-01 00:00:00
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更新日期:2017-11-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章,多中心研究
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更新日期:2018-08-01 00:00:00
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更新日期:2014-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
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journal_title:European radiology
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doi:10.1007/s003300050615
更新日期:1998-01-01 00:00:00