Abstract:
OBJECTIVE:This study aims to establish and validate a radiomics nomogram based on contrast-enhanced spectral mammography (CESM) for prediction of axillary lymph node (ALN) metastasis in breast cancer. METHODS:This retrospective study included 394 patients with breast cancer who underwent CESM examination in two hospitals. The least absolute shrinkage and selection operator (LASSO) logistic regression was established for feature selection and utilized to construct radiomics signature. The nomogram model included the radiomics signature and independent clinical factors. The receiver operating characteristic (ROC) curves were used to confirm the performance of the nomogram in training and validation sets. RESULTS:The nomogram model, which includes the radiomics signature and the CESM-reported lymph node status, has areas under the ROC curves of 0.774 (95% confidence interval (CI) 0.689-0.858), 0.767 (95% CI 0.583-0.857), and 0.79 (95% CI 0.63-0.94) in the training, internal validation, and external validation sets, respectively. We identified the cutoff score in the radiomics nomogram as - 1.49, which corresponded to a total point of 49 that could diagnose ALN metastasis with a sensitivity of > 95%. CONCLUSIONS:The CESM-based radiomics nomogram is a noninvasive predictive tool that shows good application prospects in the preoperative prediction of ALN metastasis in breast cancer. KEY POINTS:• The CESM-based radiomics nomogram shows good performance in predicting ALN metastasis in breast cancer. • The application of radiomics nomogram in this study provides a new approach for establishing a prediction model with multiple characteristics. • The nomogram has good application prospects in assisting clinical decision makers.
journal_name
Eur Radioljournal_title
European radiologyauthors
Mao N,Yin P,Li Q,Wang Q,Liu M,Ma H,Dong J,Che K,Wang Z,Duan S,Zhang X,Hong N,Xie Hdoi
10.1007/s00330-020-07016-zsubject
Has Abstractpub_date
2020-12-01 00:00:00pages
6732-6739issue
12eissn
0938-7994issn
1432-1084pii
10.1007/s00330-020-07016-zjournal_volume
30pub_type
杂志文章abstract:OBJECTIVES:To assess epiphyseal growth plate closure of the knee for forensic age estimation using an ultrasound (US)-based method and to compare the findings with MRI. METHODS:Thirty-three healthy male individuals (age, 14.4-19.3 years) were prospectively evaluated for epiphyseal growth plate closure of the right kne...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07343-1
更新日期:2020-10-14 00:00:00
abstract::To evaluate long-term effects of arterial embolization (AE) for postpartum hemorrhage (PPH) on menses recovery and subsequent pregnancies. One hundred thirteen consecutive patients, recruited from 1999 to 2006, who had undergone AE for severe PPH were evaluated in a retrospective monocentric study. As embolization age...
journal_title:European radiology
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pub_type: 杂志文章,评审
doi:10.1007/s00330-004-2627-3
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abstract:PURPOSE:3D-FLAIR sequences with delayed acquisition after contrast medium injection have demonstrated new insights into blood-labyrinthine barrier (BLB) abnormalities in various diseases. The aim of this study was to assess the BLB in patients referred with unilateral acute vestibular syndrome (UAVS). MATERIALS AND ME...
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journal_title:European radiology
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2003-07-01 00:00:00
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更新日期:2007-08-01 00:00:00
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更新日期:2019-05-01 00:00:00
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更新日期:2020-10-10 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2002-09-01 00:00:00
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更新日期:2002-12-01 00:00:00
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