Abstract：
OBJECTIVES:To determine the incremental value of non-contrast CT (NCCT) on dual-energy CT (DECT) in symptomatic first metatarsophalangeal (MTP) joints in early gout. METHODS:One hundred and fifteen painful joints were consecutively enrolled and gout was diagnosed based on the 2015 EULAR/ACR criteria and/or arthrocentesis. Two readers independently evaluated DECT alone and combined NCCT and DECT (NCCT+DECT) based on four semiquantitative scales. Sensitivities and specificities were compared using McNemar's test. AUC was compared. RESULTS:Of the 115 joints, 72 were defined as an early gout group and 43 as a gout-negative group after exclusion. The sensitivity and specificity for the early gout group on DECT alone were as followed: reader 1 - 52.8% and 100.0% and reader 2 - 51.4% and 100.0%. NCCT+DECT results were as follows: reader 1 - 79.2% and 93.0% and reader 2 - 79.2% and 95.3%. AUC was significantly higher in NCCT+DECT compared to that in DECT alone for the early gout group (0.888 vs. 0.774 for reader 1, p = 0.0004; 0.896 vs. 0.816 for reader 2, p = 0.0142). The false-negative cases on DECT occurred more frequently with the first-onset gout, and tended to be affected by a longer duration of symptoms in the post-hoc analysis. CONCLUSION:The combined analysis of NCCT and DECT improves diagnostic capabilities in symptomatic early gout involving the first MTP joint. KEY POINTS:• MSU crystal depositions in early gout may be seen on non-contrast CT, while still being undetectable by DECT. • Combining non-contrast CT and DECT improves detection of early gout. • False negatives of DECT are more common than previously reported in cases of first-onset gout.
journal_name
Eur Radioljournal_title
European radiologyauthors
Lee SK,Jung JY,Jee WH,Lee JJ,Park SHdoi
10.1007/s00330-018-5716-4subject
Has Abstractpub_date
2019-03-01 00:00:00pages
1267-1275issue
3eissn
0938-7994issn
1432-1084pii
10.1007/s00330-018-5716-4journal_volume
29pub_type
杂志文章abstract：OBJECTIVES:To evaluate the frequency of diagnosis of high-risk lesions at MRI-guided vacuum-assisted breast biopsy (MRgVABB) and to determine whether underestimation may be predicted. METHODS:Retrospective review of the medical records of 161 patients who underwent MRgVABB was performed. The underestimation rate was d...
journal_title：European radiology
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pub_type： 杂志文章,评审
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更新日期：2020-09-01 00:00:00
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更新日期：2005-02-01 00:00:00
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