Abstract:
OBJECTIVE:Assessing the advantage of x-ray dark-field contrast over x-ray transmission contrast in radiography for the detection of developing radiation-induced lung damage in mice. METHODS:Two groups of female C57BL/6 mice (irradiated and control) were imaged obtaining both contrasts monthly for 28 weeks post irradiation. Six mice received 20 Gy of irradiation to the entire right lung sparing the left lung. The control group of six mice was not irradiated. A total of 88 radiographs of both contrasts were evaluated for both groups based on average values for two regions of interest, covering (irradiated) right lung and healthy left lung. The ratio of these average values, R, was distinguished between healthy and damaged lungs for both contrasts. The time-point when deviations of R from healthy lung exceeded 3σ was determined and compared among contrasts. The Wilcoxon-Mann-Whitney test was used to test against the null hypothesis that there is no difference between both groups. A selection of 32 radiographs was assessed by radiologists. Sensitivity and specificity were determined in order to compare the diagnostic potential of both contrasts. Inter-reader and intra-reader accuracy were rated with Cohen's kappa. RESULTS:Radiation-induced morphological changes of lung tissue caused deviations from the control group that were measured on average 10 weeks earlier with x-ray dark-field contrast than with x-ray transmission contrast. Sensitivity, specificity, and accuracy doubled using dark-field radiography. CONCLUSION:X-ray dark-field radiography detects morphological changes of lung tissue associated with radiation-induced damage earlier than transmission radiography in a pre-clinical mouse model. KEY POINTS:• Significant deviations from healthy lung due to irradiation were measured after 16 weeks with x-ray dark-field radiography (p = 0.004). • Significant deviations occur on average 10 weeks earlier for x-ray dark-field radiography in comparison to x-ray transmission radiography. • Sensitivity and specificity doubled when using x-ray dark-field radiography instead of x-ray transmission radiography.
journal_name
Eur Radioljournal_title
European radiologyauthors
Burkhardt R,Gora T,Fingerle AA,Sauter AP,Meurer F,Umkehrer S,von Teuffenbach M,Kampfer S,Schilling D,Feuchtinger A,Walch AK,Rummeny E,Combs SE,Schmid TE,Pfeiffer F,Wilkens JJ,Herzen Jdoi
10.1007/s00330-020-07459-4subject
Has Abstractpub_date
2020-11-19 00:00:00eissn
0938-7994issn
1432-1084pii
10.1007/s00330-020-07459-4pub_type
杂志文章abstract:OBJECTIVES:To compare the significance of the two-compartment model, considering diffusional anisotropy with conventional diffusion analyzing methods regarding the detection of occult changes in normal-appearing white matter (NAWM) of multiple sclerosis (MS). METHODS:Diffusion-weighted images (nine b-values with six d...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3572-4
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVES:To evaluate the methodological quality of diagnostic accuracy studies on coronary computed tomography (CT) angiography using the QUADAS (Quality Assessment of Diagnostic Accuracy Studies included in systematic reviews) tool. METHODS:Each QUADAS item was individually defined to adapt it to the special requir...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2763-0
更新日期:2013-06-01 00:00:00
abstract::The purpose of this study was to evaluate the reproducibility of CT-volumetric tumour response assessment of pulmonary metastasis using variable volume change thresholds (VCT) and target lesions with response evaluation criteria in solid tumours (RECIST). Fifty consecutive patients with pulmonary metastases undergoing...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-007-0642-x
更新日期:2007-10-01 00:00:00
abstract::We describe changes in imaging features of a textiloma (retained surgical sponge or retained foreign body) left in the renal fossa after exploratory renal surgery. One year after the initial surgery, the MR aspect of the textiloma was not specific, with a homogeneous low signal intensity on T1-weighted images. Serial ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050338
更新日期:1998-01-01 00:00:00
abstract::Lung tumour ablation with a thin-calibre laser applicator system was evaluated. We quantified feasibility, technical success and complication rates in relation to lesion diameter and location. Forty-two patients with 64 lung tumours were treated (39 patients with metastases and three with primary tumours). Mean follow...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-006-0171-z
更新日期:2006-08-01 00:00:00
abstract::The purpose of this study was to compare LV function and mass quantification derived from cardiac dual-source CT (DSCT) exams with those obtained by MRI in heart transplant recipients. Twelve heart transplant recipients who underwent cardiac DSCT and MRI examination were included. Double-oblique short-axis 8-mm slice ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-008-0949-2
更新日期:2008-09-01 00:00:00
abstract::We report on an isolated enlargement of the fourth ventricle in a patient with neurosarcoidosis which developed 3 years after the insertion of a ventriculo-atrial shunt. Repeated MRI images were obtained in a patient with known neurosarcoidosis between 1995 and 2000. Imaging findings were correlated to the medical cou...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-002-1369-3
更新日期:2002-12-01 00:00:00
abstract::The purpose of our animal study was to evaluate a new computed tomography (CT) subtraction technique for visualization of perfusion defects within the lung parenchyma in subsegmental pulmonary embolism (PE). Seven healthy pigs were entered into a prospective trial. Acute PE was artificially induced by fresh clot mater...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-005-2718-9
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:To investigate the detectability of pulmonary nodules in chest tomosynthesis at reduced radiation dose levels. METHODS:Eighty-six patients were included in the study and were examined with tomosynthesis and computed tomography (CT). Artificial noise was added to simulate that the tomosynthesis images were ac...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3182-1
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To determine the diagnostic performance of a deep learning (DL) model in evaluating myometrial invasion (MI) depth on T2-weighted imaging (T2WI)-based endometrial cancer (EC) MR imaging (ECM). METHODS:We retrospectively enrolled 530 patients with pathologically proven EC at our institution between January 1,...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06870-1
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:To assess the diagnostic accuracy and illustrate positive findings of contrast-enhanced fluorine-18 fluoro-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) image in patients awaiting liver transplantation (LT) with rising alpha-fetoprotein (AFP) after bridge therapy of hepatocellula...
journal_title:European radiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00330-018-5425-z
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:To investigate the impact of automated attenuation-based tube potential selection on image quality and exposure parameters in polytrauma patients undergoing contrast-enhanced thoraco-abdominal CT. METHODS:One hundred patients were examined on a 16-slice device at 120 kV with 190 ref.mAs and automated mA modu...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3197-7
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVES:To assess the combined role of tumor vascularity, estimated from perfusion MRI, and MGMT methylation status on overall survival (OS) in patients with glioblastoma. METHODS:A multicentric international dataset including 96 patients from NCT03439332 clinical study were used to study the prognostic relationshi...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07297-4
更新日期:2020-10-01 00:00:00
abstract::Bilioma is a rare complication of traumatic liver injury, and the precise site of bile leak is often difficult to demonstrate with a non-invasive technique. We report a case of post-traumatic bile leak in a 15-year-old girl in whom spiral CT after intravenous cholangiography allowed excellent preoperative demonstratio...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050637
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To compare cardiac left ventricular (LV) parameters in simultaneously acquired hybrid fluorine-18-fluorodeoxyglucose ([18F] FDG) positron emission tomography/magnetic resonance imaging (PET/MRI) in patients with residual tracer activity of upstream PET/CT. METHODS:Twenty-nine patients (23 men, age 58±17 year...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-4896-7
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVES:To determine the residual lipid fraction in fractured vertebrae by (1)H MR spectroscopy (MRS) and its confounding effect on differentiating benign from metastatic compression fractures of the spine using apparent diffusion coefficient (ADC) obtained by diffusion-weighted read-out-segmented echo-planar imagin...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2620-1
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVES:To compare single-energy (SECT) and dual-energy (DECT) abdominal CT examinations in matched patient cohorts regarding differences in radiation dose and image quality performed with second- and third-generation dual-source CT (DSCT). METHODS:We retrospectively analysed 200 patients (100 male, 100 female; mea...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4383-6
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:To assess the radiation dose received by the radiologist when performing wire localisation for axillary radio-isotope sentinel node imaging-guided biopsy in patients with impalpable breast cancers treated with breast-preserving excision. When wire placement follows radio-isotope sentinel node imaging (RSNI) t...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-009-1594-0
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVES:To determine association of gross tumour volume (GTV) of resectable oesophageal squamous cell carcinoma (SCC) measured on T2-weighted imaging (T2WI), contrast-enhanced T1-weighted imaging (CE-T1WI) and diffusion-weighted imaging (DWI) with T category and lymphatic metastasis (LM). METHODS:Sixty oesophageal ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5477-0
更新日期:2018-11-01 00:00:00
abstract::Lesion area measurement in multiple sclerosis (MS) is one of the key points in evaluating the natural history and in monitoring the efficacy of treatments. This study was performed to check the intra- and inter-observer agreement variability of a locally developed Growing Region Segmentation Software (GRES), comparing...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300100978
更新日期:2002-04-01 00:00:00
abstract::Uterus didelphys with obstructed hemivagina and ipsilateral renal agenesis is a rare and specific entity referred to as Herlyn-Werner-Wunderlich syndrome. It usually presents after menarche with remittent pelvic pain and a palpable pelvic mass due to hematocolpos. It rarely presents with primary infertility in early a...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-008-1085-8
更新日期:2009-05-01 00:00:00
abstract::The aim of this study was to assess the potential of high-speed interleaved echo-planar imaging (EPI) to achieve diagnostic image quality comparable to T2-weighted imaging in patients with brain tumors. Seventeen patients with intra-axial, supratentorial tumors (10 untreated gliomas, 7 radiated gliomas) were investiga...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050854
更新日期:1999-01-01 00:00:00
abstract::Meningeal hemangiopericytoma (MHP) is extremely rare in childhood. Mean age at diagnosis is between 38 and 43 years. We present an 8-year-old boy with MHP of the middle cranial fossa. Imaging findings were indistinguishable from an aggressive bone tumor such as Ewing's sarcoma. Imaging findings are presented and discu...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003309900222
更新日期:2000-01-01 00:00:00
abstract::The aim of this study was to assess the capability of a 3D isotropic MRI T2-weighted sequence (3D T2 ISO) in the depiction of changes of neurovascular bundles (NVBs) after bilateral nerve-sparing radical retropubic prostatectomy (RRP). Furthermore, our aim was also to introduce a new MRI classification score of the NV...
journal_title:European radiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00330-008-1102-y
更新日期:2009-01-01 00:00:00
abstract::We here introduce a digital scanning method for determining leg length and angles. The leg length and angle measurements, image quality and radiation dose were evaluated. A composite overview image was reconstructed from a series of individual images. In 45 overview images, the total leg length and the femoro-tibial a...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-004-2352-y
更新日期:2005-01-01 00:00:00
abstract::The potential relative beneficial aspects of upright, weight-bearing (pMRI), dynamic-kinetic (kMRI) spinal imaging over that of recumbent MRI (rMRI) include the revelation of occult spinal disease dependent on true axial loading, the unmasking of kinetic-dependent spinal disease and the ability to scan the patient in ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-005-2666-4
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVE:To compare pulmonary high-resolution CT (HRCT) findings in patients with Pseudomonas aeruginosa pneumonia to HRCT findings in patients with Cytomegalovirus (CMV) pneumonia. METHODS:We studied 124 patients (77 men, 47 women; age range, 20-89 years; mean age, 65.4 years) with P. aeruginosa pneumonia and 44 pat...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3326-3
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:To apply an easy-to-assemble phantom substitute for human prostates in T2-weighted magnetic resonance imaging (T2WI), diffusion-weighted imaging (DWI) and 3D magnetic resonance spectroscopy (MRS). METHODS:Kiwi fruit were fixed with gel hot and cold compress packs on two plastic nursery pots, separated by a ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4706-7
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVES:Investigate the effect of a novel Bayesian penalised likelihood (BPL) reconstruction algorithm on analysis of pulmonary nodules examined with 18F-FDG PET/CT, and to determine its effect on small, sub-10-mm nodules. METHODS:18F-FDG PET/CTs performed for nodule evaluation in 104 patients (121 nodules) were re...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-3832-y
更新日期:2016-02-01 00:00:00
abstract::In acute nonvariceal gastrointestinal (GI) bleeding, immediate arteriographic haemostasis is presently assumed to be a therapeutic advantage. This study assesses whether the risk of a delayed haemostasis, caused by arteriographic findings precluding embolization, might influence patient outcome. We performed a 5.5-yea...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-003-1882-z
更新日期:2003-12-01 00:00:00