Abstract:
OBJECTIVE:To assess the diagnostic accuracy and illustrate positive findings of contrast-enhanced fluorine-18 fluoro-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) image in patients awaiting liver transplantation (LT) with rising alpha-fetoprotein (AFP) after bridge therapy of hepatocellular carcinoma (HCC). MATERIALS AND METHODS:This prospective study included 100 patients who were waiting for LT and who previously underwent locoregional therapy (LRT) of HCC. These patients had rising AFP levels on a routine follow-up examination awaiting LT. All patients underwent a contrast-enhanced 18F-FDG PET/CT examination. We calculated for each patient the maximum standardised uptake value (SUVmax) of the tumour and the ratio of the tumoral SUVmax to the normal-liver SUVmax. The diagnostic accuracy and positive contrast-enhanced findings of 18F-FDG PET/CT were established by histopathology and clinical and imaging follow-up as the reference standards. RESULTS:Contrast-enhanced 18F-FDG PET/CT detected tumour relapse in 78 patients (13 patients had intrahepatic lesions, 10 patients had extrahepatic metastases and 55 patients with combined lesions). The sensitivity, specificity and accuracy values of contrast-enhanced 18F-FDG PET/CT examination in the detection of HCC recurrence were 92.8%, 94.1% and 93%, respectively. A significant correlation was found between the AFP level and SUVmax ratio (r = 0.2283; p = 0.0224). The best threshold for 18F-FDG PET positivity was >1.21. CONCLUSION:Contrast-enhanced 18F-FDG PET/CT is a valuable tool for the detection of intrahepatic HCC recurrence or extrahepatic metastasis following rising AFP levels after LRT of HCC, and should be incorporated during routine workup awaiting LT. KEY POINTS:• 18F-FDG PET/CT is a valuable tool for the detection of HCC recurrence • 18 F-FDG PET/CT should be incorporated during routine workup awaiting liver transplantation • Significant correlation was found between AFP level and SUVmax ratio • The best threshold for 18 F-FDG PET positivity was >1.21 • The ideal cut-off value for AFP was >202.
journal_name
Eur Radioljournal_title
European radiologyauthors
Refaat R,Basha MAA,Hassan MS,Hussein RS,El Sammak AA,El Sammak DAEA,Radwan MHS,Awad NM,Saad El-Din SA,Elkholy E,Ibrahim DRD,Saleh SA,Montasser IF,Said Hdoi
10.1007/s00330-018-5425-zsubject
Has Abstractpub_date
2018-12-01 00:00:00pages
5356-5367issue
12eissn
0938-7994issn
1432-1084pii
10.1007/s00330-018-5425-zjournal_volume
28pub_type
杂志文章,多中心研究abstract::We aimed to determine the mean hepatic artery resistance index (RI) in presinusoidal portal hypertension and to compare the values with those in sinusoidal portal hypertension. The hepatic artery RIs of 11 patients with presinusoidal portal hypertension, 12 patients with sinusoidal portal hypertension and 16 healthy s...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050806
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:To investigate pulmonary vasculature opacification during CTPA using an optimised patient-specific protocol for administering contrast agent. METHODS:CTPA was performed on 200 patients with suspected PE. Patients were assigned to two protocol groups: protocol A, fixed 80 ml contrast agent; protocol B used a...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-2919-6
更新日期:2013-11-01 00:00:00
abstract::The aim of this study was to compare the performance of the CT and the water-soluble contrast enema (CE) in the diagnosis and the severity of acute left-colonic diverticulitis, and to recognize the impact of CT during the acute phase and after a first acute episode successfully treated medically. From 1986 to 1997, al...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-001-1143-y
更新日期:2002-05-01 00:00:00
abstract::Osteochondritis (osteochondrosis) dissecans (OCD) is a common condition in children, adolescents, and young adults. Describing OCD together with osteochondral fractures and epiphyseal ossification disturbances and considering these three conditions as one entity has caused much confusion. Age distribution and localiza...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s003300050348
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:The principal aim of our study was to establish concordance between post-mortem CT (PMCT) and forensic standard autopsy (SA) in detecting lesions according to different anatomical regions. A secondary aim was to determine the efficacy of PMCT in showing lethal lesions. METHODS:PMCTs were compared with autop...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-2779-0
更新日期:2013-07-01 00:00:00
abstract::The purpose of this study was to assess the prevalence of lung cancer in a high-risk asbestos-exposed cohort using low-dose MDCT. Of a population of 5,389 former power-plant workers, 316 were characterized as individuals at highest risk for lung cancer according to a lung-cancer risk model including age, asbestos expo...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-006-0426-8
更新日期:2007-05-01 00:00:00
abstract::The etiological role of concha bullosa in chronic sinusitis is controversial. Previous investigators have not studied the relationship between the location of concha bullosa and different chronic sinusitis patterns. We performed coronal paranasal sinuses CT in 100 Chinese patients with signs and symptoms of chronic si...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/BF00182491
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:Clinical hepatic diffusion weighted imaging (DWI) generally relies on mono-exponential diffusion. The aim was to demonstrate that mono-exponential diffusion in the liver is contaminated by microperfusion and that the bi-exponential model is required. METHODS:Nineteen fasting healthy volunteers were examined ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-011-2313-1
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVES:Assessment of empirical diffusion-weighted MRI (DW-MRI) models in cervical tumours to investigate whether fitted parameters distinguish between types and grades of tumours. METHODS:Forty-two patients (24 squamous cell carcinomas, 14 well/moderately differentiated, 10 poorly differentiated; 15 adenocarcinoma...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4417-0
更新日期:2017-02-01 00:00:00
abstract::Our objective was to find a tracer in diagnosing human pancreatic cancer using positron emission tomography (PET). For this purpose in vitro test of pancreatic tissues with autoradiography was used. Autoradiography was performed with (11)C-harmine (a MAO-A-inhibitor) with and without competitive inhibition. Tissue pre...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-002-1443-x
更新日期:2003-04-01 00:00:00
abstract::Defining the origin of low back pain is a challenging task. Among a variety of factors the sacroiliac joint (SIJ) is a possible pain generator, although precise diagnosis is difficult. Joint blocks may reduce pain, but are, in cases, of only temporary effect. This study was conducted to evaluate CT-guided percutaneous...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-001-1257-2
更新日期:2002-06-01 00:00:00
abstract::Coronary computed tomography angiography (CTA) has been established as an accurate method to non-invasively assess coronary artery disease (CAD). The proposed 'Coronary Artery Disease Reporting and Data System' (CAD-RADS) may enable standardised reporting of the broad spectrum of coronary CTA findings related to the p...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-017-5105-4
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:To model the uptake phase of T(1)-weighted DCE-MRI data in normal kidneys and to demonstrate that the fitted physiological parameters correlate with published normal values. METHODS:The model incorporates delay and broadening of the arterial vascular peak as it appears in the capillary bed, two distinct comp...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2382-9
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To investigate the value of histogram analysis of diffusion kurtosis imaging (DKI) maps in the evaluation of glioma grading. METHODS:A total of 39 glioma patients who underwent preoperative magnetic resonance imaging (MRI) were classified into low-grade (13 cases) and high-grade (26 cases) glioma groups. Par...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-5108-1
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:Coronary angiography using multidetector computed tomography (MDCT) allows non-invasive assessment of non-calcified, calcified and mixed plaques. Progression of coronary plaques may be influenced by statins. METHODS:Sixty-three consecutive patients underwent MDCT as a follow-up to their original CT angiograp...
journal_title:European radiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00330-010-1880-x
更新日期:2010-12-01 00:00:00
abstract:PROPOSE:To establish evidence-based recommendations for musculoskeletal kinematic 4D-CT on wide area-detector CT. MATERIALS AND METHODS:In order to assess factors influencing image quality in kinematic CT studies, a phantom consisting of a polymethylmethacrylate rotating disk with round wells of different sizes was im...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4362-y
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVES:To evaluate changes in T1 and T2* relaxometry of dentate nuclei (DN) with respect to the number of previous administrations of Gadolinium-based contrast agents (GBCA). METHODS:In 74 relapsing-remitting multiple sclerosis (RR-MS) patients with variable disease duration (9.8±6.8 years) and severity (Expanded ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4245-2
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:To assess the radiation dose received by the radiologist when performing wire localisation for axillary radio-isotope sentinel node imaging-guided biopsy in patients with impalpable breast cancers treated with breast-preserving excision. When wire placement follows radio-isotope sentinel node imaging (RSNI) t...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-009-1594-0
更新日期:2010-03-01 00:00:00
abstract::Placenta percreta is a potentially life-threatening complication of pregnancy, which is increasing in incidence. Ante-natal diagnosis with ultrasound and magnetic resonance imaging aids the obstetric team in planning further management. We present a case of placenta percreta with imaging and a brief review of the lite...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-006-0498-5
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVES:To compare contrast-to-noise ratios (CNRs) and iodine discrimination thresholds on iodine maps derived from dual energy CT (DECT) and subtraction CT (SCT). METHODS:A contrast-detail phantom experiment was performed with 2 to 15 mm diameter tubes containing water or iodinated contrast concentrations ranging ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5496-x
更新日期:2018-12-01 00:00:00
abstract::Endovascular treatment options for visceral artery pseudoaneurysms depend on lesion location and size. Exclusion methods fall into two categories, embolization and stent placement, and these procedures aim to exclude the pseudoaneurysm from the circulation and if possible to maintain distal blood flow. Embolization of...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-008-1053-3
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVES:To investigate the added diagnostic value of arterial spin labelling (ASL) and diffusion tensor imaging (DTI) to structural MRI for computer-aided classification of Alzheimer's disease (AD), frontotemporal dementia (FTD), and controls. METHODS:This retrospective study used MRI data from 24 early-onset AD an...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4691-x
更新日期:2017-08-01 00:00:00
abstract::In paediatric radiology it has been recognised that children have a higher risk of developing cancer from the irradiation than adults (two to three times); therefore, increased attention has been directed towards the dose to the patient. In this study the effect on patient dose and image quality in replacing the expos...
journal_title:European radiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00330-003-2144-9
更新日期:2004-04-01 00:00:00
abstract::Lung tumour ablation with a thin-calibre laser applicator system was evaluated. We quantified feasibility, technical success and complication rates in relation to lesion diameter and location. Forty-two patients with 64 lung tumours were treated (39 patients with metastases and three with primary tumours). Mean follow...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-006-0171-z
更新日期:2006-08-01 00:00:00
abstract::Magnetization transfer (MT) provides post-gadolinium contrast improvement through decreasing the tissue signal. Our study had two aims: to analyse the effect of MT qualitatively and quantitatively in 13 patients, and to analyse in vitro the competition between two relaxation phenomena, dipole-dipole which is character...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/pl00006889
更新日期:1997-01-01 00:00:00
abstract::To quantify permeability changes of the "blood-bone marrow barrier" (BMB) and to detect malignant bone marrow infiltrations before and after conditioning therapy for subsequent leukapheresis using ferumoxtran-10-enhanced magnetic resonance (MR) imaging. Twenty-two patients with malignant non-Hodgkin lymphomas (NHL), i...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-005-0045-9
更新日期:2006-03-01 00:00:00
abstract::The aim of this study was to evaluate the usefulness of diffusion-weighted imaging (DWI) in detecting seminal vesicle invasion (SVI). A total of 283 patients underwent conventional MRI and DWI before prostate cancer surgery. The apparent diffusion coefficient (ADC) values of all PCa foci, SVI and seminal vesicle were ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-009-1428-0
更新日期:2009-10-01 00:00:00
abstract::Our objective was to assess the clinical value of an early arterial scan for assessing the hepatic and mesenteric vasculature in patients with suspected primary or metastatic hypervascular liver disease undergoing multislice computed tomography. In 42 patients a very early arteriographic scan was performed before stan...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-002-1566-0
更新日期:2003-05-01 00:00:00
abstract::The peritoneum is a mesothelial lining of the abdominal cavity (parietal) and intraperitoneal viscera (visceral). The cavity contains a small amount of fluid, which circulates from cephalad to caudal to cephalad, influenced by negative pressure under the diaphragm during exhalation, gravity, and bowel peristalsis. Per...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s003300100998
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:To evaluate whole-body MRI with diffusion-weighted sequence (WB-DWI/MRI) for staging and assessing operability compared with CT and FDG-PET/CT in patients with suspected ovarian cancer. METHODS:Thirty-two patients underwent 3-T WB-DWI/MRI, (18) F-fluorodeoxyglucose positron emission tomography/computed tomo...
journal_title:European radiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00330-013-3083-8
更新日期:2014-04-01 00:00:00