Abstract：
:Some aspects of the functional significance of sleep are considered. These involve studies on (i) the dynamics of electrical activity in the neo- and archi-paleocortical structures of the brain in the sleep-wakefulness cycle, (ii) the effect of selective deprivation of different sleep phases on the sleep-wakefulness cycle, (iii) effect of stimulating synchronizing and desynchronizing systems on the sleep-wakefulness cycle, and (iv) the dynamics of emotional tension in the sleep-wakefulness cycle. Analysis of our findings and their comparison with those reported in the literature support a hypothesis that every phase in the sleep-wakefulness cycle operates in two directions; it withdraws the factors formed in the previous phase which are potentially aimed at disturbing brain homeostasis; and, at the same time, it forms new antihomeostatic factors, withdrawal of which requires the triggering and work of a subsequent phase. The triggering links of the systems regulating each phase are very sensitive to the factors formed in the preceding phase. Therefore, in normal conditions the anti-homeostatic factors fail to attain a critical level of disturbance of homeostasis of the brain, since the threshold for their activation is far lower than the critical level of homeostatic disturbance. Activation of the triggering links of the paradoxical phase and wakefulness seems to be mediated through the same anti-homeostatic factors formed in the orthodox phase. However, the threshold for activation of the paradoxical phase is lower than that of wakefulness. As a consequence, the orthodox phase readily passes into the paradoxical. The latter, effectively reducing the antihomeostatic factors formed in the orthodox phase, prevents the onset of undue awakening that would have been undesirable because there would have been insufficient time for inactivation of the anti-homeostatic factors formed during wakefulness.
journal_name
Acta Neurobiol Exp (Wars)journal_title
Acta neurobiologiae experimentalisauthors
Oniani TNsubject
Has Abstractpub_date
1977-01-01 00:00:00pages
223-46issue
4eissn
0065-1400issn
1689-0035journal_volume
37pub_type
杂志文章abstract：:A review of recent anatomical evidence shows that every neocortical area and many nuclei from the dorsal thalamus project to restricted neostriatal regions. The neurobehavioral literature offers many examples of the same results obtained with lesions, stimulations or recordings in a neocortical area and the associated...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1972-01-01 00:00:00
abstract：:Human umbilical cord blood (HUCB) is considered a promising source of neural progenitors capable of being used for cellular therapies in neurological disorders. Here we review briefly our work on the elucidation of mechanisms and development of practical standards as regards the selection, maintenance and use of cord ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:A modified method of injection into the cerebellomedullary (CM) cistern of mice was developed based on fixation of the mouse with a special mask under inhalation anesthesia, and exposure of the sagittal suture of the cranium and midline of the nape to allow us to visualize injection point directly. The accuracy of the...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：:Twenty-two rats were reared in standard conditions during the first two months of their life. Then the animals were divided into two groups exposed to different rearing conditions. Twelve animals (Group SO) were housed socially, six animals per cage, and for three weeks they were subjected to sensory stimulation in an...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:For years, interneurons expressing vasoactive intestinal peptide (VIP) interneurons and their function within the neocortex have been shrouded in mystery. Their relatively small size and minimal representation in the cortex have made investigation difficult. Due to their service role performed in co‑operation with gli...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2019-01-01 00:00:00
abstract：:In this study we evaluated biochemical blood serum parameters and the association of Cyclin-dependent kinase 5 (CDK5) gene polymorphisms with the risk of Alzheimer's disease (AD) in the Polish population. We observed an elevated total cholesterol, low-density lipoproteins (LDL) and homocysteine levels and lower concen...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:Anxiety and depression have dramatic impact on human and animal behaviors. We take an interdisciplinary approach and review the existing experimental models of anxiety and depression in order to promote further understanding of neurobiological aspects of anxiety and depression. ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2004-01-01 00:00:00
abstract：:The pattern of GnRH secretion during the follicular phase of the estrous cycle of sheep is characterized by an initial marked change in episodic secretion (increased frequency and decreased amplitude) followed by a massive and sustained discharge-the preovulatory GnRH surge. Studies employing a physiological model for...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
abstract：:Transient elimination of visual stimuli (20 min darkness in the experimental chamber) did not affect the amphetamine induced stereotyped behavior and accompanied arousal in cats. It is concluded that anqhetamine stereotyped behavior in cats represents centrally initiated event of animal response to drug which is, unde...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Quercetin, one of the major flavonoids, exhibits many beneficial effects on human organism as antihistamine, antioxidant, anti-inflammatory, anticancer and antiviral drug. It is recommended as supplement of healthy diet but still the knowledge of its beneficial effect on normal cells is not satisfactory. We decided to...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:The intranuclear membranaceus inclusions (IMI) appear as encapsulated irregular vacuoles surrounded by a single, rarely double, membrane. The vacuoles include floccular, fine granular content or they are translucent. They were found in neurones of particularly old or very young laboratory animals. Our studies concerni...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:A differentiation of instrumental responses to auditory location stimuli using the Konorski Test was investigated. Each stimulus consisted of two components separated by intrastimulus interval. The components were click series presented from four loudspeakers situated in front of the animal, on horizontal and vertical...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Recognizing objects from the past is a vitally important ability for everyday live. The studies of brain mechanisms responsible for visual recognition memory suggest that the modulation of single unit activity in the inferotemporal and perirhinal cortices could be an important part of the neuronal substrate of recogni...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
abstract：:Partial deafferentation of the hippocampus due to trimethyltin (TMT) intoxication has been reported to induce plastic rearrangements of neuronal elements but the factors that direct these responses are unknown. To assess the possible involvement of nerve growth factor (NGF) in the phenomenon we evaluated the presumabl...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:This study aimed to provide a simple way to approach group differences by independent component analysis when researching functional connectivity changes of resting-state network in brain disorders. We used baseline resting state functional magnetic resonance imaging from the Alzheimer's disease neuroimaging initiativ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：10.21307/ane-2017-028
更新日期：2016-01-01 00:00:00
abstract：:In the context of cell therapy, the epigenetic status of core stemness transcription factor (STF) genes regulating the cell proliferation/differentiation program is of primary interest. Our results confirmed that in vitro differentiation of the umbilicalcord-blood-derived-neural-stem-cells (HUCB-NSC) coincides with th...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：:Functional interactions between serotoninergic and GABAergic systems in the vertebrate retina are largely unknown. In this study, the effects of isolated or combined stimulation of the serotonin receptors (with 100 μM serotonin) and ionotropic GABAA and GABAC receptors (with 5 mM TACA) on the electroretinographic (ERG...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2017-01-01 00:00:00
abstract：:Rats with electrolytic lesions of the nucleus basalis magnocellularis were compared to sham-lesioned rats in the retention of a continuously reinforced lever-pressing response and in the acquisition and reversal of a visual discrimination task. The muscarinic agonist pilocarpine, in conjunction with the peripheral mus...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:The reasons for the rise in autism prevalence are a subject of heated professional debate. Featuring a critical appraisal of some research used to question whether rising levels of autism are related to environmental exposure to toxins (Soden et al. 2007, Barbaresi et al. 2009, Thompson et al. 2007) we aim to evaluate...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:A new method of investigating animal locomotion is presented which allows for the simultaneous measurement of the basic overground locomotion parameters: swing and stance durations, stride lengths, velocity of movement, gait diagrams and temporal relationships between all animal limbs. The measurements and recordings ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:It is well known that the fetal ethanol exposure and prenatal stress may have adverse effects on brain development. Interestingly, some morphological and functional recovery from their teratogenic effects that take place during brain maturation. However, mechanisms that underlie this recovery are not fully elucidated....
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2019-01-01 00:00:00
abstract：:Deprivation of patterned visual information, as in early onset congenital cataract patients, results in a severe impairment in global motion perception. Previously we reported a delayed maturation of the peripheral visual field representation in primary visual area 17, based on a 2-D DIGE screen for protein expression...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2017-01-01 00:00:00
abstract：:In four dogs instrumental defensive conditioned reflexes to direct electrical stimulation of the hippocampus were elaborated. After reaching 60 percent CR performance, unreinforced stimulations of several limbic structures were given to test generalization. Positive generalization was more frequent than negative one. ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:The superior colliculus has been implicated in visual orientation and localization in several mammalian species. To examine this possibility in rhesus monkeys, we trained monkeys to respond to one of six locations signaled by a small light of 5 s duration that was turned off immediately before they were allowed to res...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Temporal information processing controls many aspects of human mental activity and may be assessed by examining perception of temporal order in the tens of milliseconds time range. Although existing studies suggest an age-related decline in mental abilities, the data on the deterioration of temporal order perception s...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:The parabrachial complex has been related to various rewarding or aversive behavioral processes, including taste aversion learning and conditioned place aversion. This study examined the effect of tiapride, an antagonist of D2/D3 dopaminergic receptors, on place aversion induced by electrical stimulation of the extern...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:Parkinson's disease (PD) is a common neurodegenerative disease that appears essentially as a sporadic condition. PD is well known to be a chronic and progressive neurodegenerative disease produced by a selective degeneration of dopaminergic neurons in the substantia nigra pars compacta. The main clinical features of P...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：:The mammalian pineal organ contains photoreceptor-specific proteins, whose distribution shows conspicuous variation among different species of mammals. Nevertheless, the following general conclusions can be drawn: immunoreactions for S-antigen and recoverin labeled more pinealocytes than the rod-opsin immunoreaction. ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
abstract：:A motor alimentary conditioned reflex was elaborated in hippocampectomized and intact albino rats. Food reinforcement followed 100 percent, 50 percent, 33 percent or 25 percent of conditional stimulus presentations (click from a rotating food box). No differences were found in the rate of conditioned alimentary reflex...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1974-01-01 00:00:00
abstract：:Response generalization to a novel stimulus occurs when the new stimulus shares common features with the stimulus used in the original learning. Given the many recent studies suggesting that the perirhinal cortex is critical for disambiguating stimuli that share representational/perceptual elements, we hypothesize tha...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
