Abstract：
:Quercetin, one of the major flavonoids, exhibits many beneficial effects on human organism as antihistamine, antioxidant, anti-inflammatory, anticancer and antiviral drug. It is recommended as supplement of healthy diet but still the knowledge of its beneficial effect on normal cells is not satisfactory. We decided to examine the effect of flavonoid on neurons morphology and their susceptibility to cell death. Fractal analysis of rat neurons revealed that 24 hours long incubation with quercetin diminished neuronal arborisation in cortical neurons. Neurons also appeared to be very sensitive to cell death after flavonoid treatment in concentration dependent manner. Over 50% of cells died after incubation with 15 mu/ml of flavonoid while 1 mu/ ml of quercetin induced cell death only in 5%. Staining with Hoechst 33342 and propidium ioidide revealed the two types of cell death: apoptosis and necrosis. The number of apoptotic cells was comparable with necrotic ones. These results suggest toxic effect of quercetin on neurons what should be taken into consideration in further studies on using quercetin as therapeutic agent.
journal_name
Acta Neurobiol Exp (Wars)journal_title
Acta neurobiologiae experimentalisauthors
Jakubowicz-Gil J,Rzeski W,Zdzisinska B,Dobrowolski P,Gawron Asubject
Has Abstractpub_date
2008-01-01 00:00:00pages
139-46issue
2eissn
0065-1400issn
1689-0035pii
6818journal_volume
68pub_type
杂志文章abstract：:Leukemia inhibitory factor (LIF) is a neuroprotective cytokine that is necessary for the normal development of astrocytes. Oxygen-glucose deprivation (OGD) can induce astrocyte proliferation by increasing hypoxia-inducible factor alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF). Here, we studied whethe...
journal_title：Acta neurobiologiae experimentalis
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doi：
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journal_title：Acta neurobiologiae experimentalis
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doi：
更新日期：1973-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
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doi：
更新日期：1986-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
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doi：
更新日期：1980-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：1980-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1974-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：10.21307/ane-2017-017
更新日期：2016-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
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doi：
更新日期：2018-01-01 00:00:00
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doi：
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更新日期：1981-01-01 00:00:00
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更新日期：1981-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
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doi：
更新日期：2018-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
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doi：
更新日期：1993-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
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更新日期：1992-01-01 00:00:00
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更新日期：1997-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
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doi：
更新日期：2018-01-01 00:00:00
