Abstract：
:Huntington's disease is an autosomal dominant progressive neurodegenerative disease, which results in a decreased quality of life and an early death. A high prevalence of vitamin D deficiency was first described in a 2013 study in patients with manifest Huntington's disease, where serum vitamin D level was found to be associated with motor capabilities of the patients. Our objective was to investigate the effect of a high-dose vitamin D3 supplementation on a transgenic mouse model of Huntington's disease. Our study was performed on N171-82Q Huntington's disease transgenic mice in age- and gender-matched groups. We collected data on the motor state and survival of the mice. The results demonstrate that though vitamin D3 had no effect on the motor performance of transgenic mice, but significantly increased the lifespan of transgenic animals (Kaplan-Meier survival curves: vehicle-supplemented group: 73 (67-94) days vs. vitamin D3-supplemented group: 101 (74-109) days, p=0.048 Mantel-Cox log rank test). Further investigations are needed to determine whether a neuroprotective or a general corroborative effect of vitamin D leads to the measured effect. Our findings support the potential influence of vitamin D deficiency on the disease course and propose that vitamin D may be an effective supplementary treatment to beneficially influence clinical features of Huntington's disease.
journal_name
Acta Neurobiol Exp (Wars)journal_title
Acta neurobiologiae experimentalisauthors
Molnár MF,Török R,Szalárdy L,Sümegi E,Vécsei L,Klivényi Pdoi
10.21307/ane-2017-017subject
Has Abstractpub_date
2016-01-01 00:00:00pages
176-81issue
3eissn
0065-1400issn
1689-0035pii
7617journal_volume
76pub_type
杂志文章abstract：:Multiple neuronal activity, recorded through chronically implanted electrodes, was analyzed. During acquisition and consolidation of alimentary conditioned reflexes to electrostimulation of the lateral geniculate body or optical tract, the patterns of neuronal activity in the visual cortex and sensory motor cortex bec...
journal_title：Acta neurobiologiae experimentalis
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doi：
更新日期：1979-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
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journal_title：Acta neurobiologiae experimentalis
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doi：
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
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pub_type： 杂志文章
doi：
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doi：
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doi：
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doi：
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更新日期：2005-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
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doi：
更新日期：1992-01-01 00:00:00
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