Abstract：
:The authors investigated the effect of physostigmine (Ph) on short-term memory underlying the response-to-change test in rats. In the first test trial (acquisition) the rat could observe the white-black T-maze arms through transparent partitions which prevented the entrance to the arms. In the subsequent trial the rat was allowed a free choice between two identical maze arms, one of them being changed from white to black or vice versa. Physostigmine or saline (NaCl) was injected i.p. 1 min after the acquisition trial. When the retention interval between the two trials was short (10 min), NaCl rats showed a significant preponderance of the changed arm choices, whereas after a longer retention interval (20 min) they selected the changed arm in low percentage. This indicated a rapid decline of memory traces underlying the response to the change of brightness. Physostigmine in a dose of 0.1 mg/kg blocked responding to change after 10 min retention interval, when the memory was strong. However, when tested after a 20 min interval, Ph injected rats showed restoration of memory. After a 15 min interval, retention in both NaCl and Ph injected rats was on a similar, intermediate level. A higher dose of Ph (0.3 mg/kg) had no effect on responding to change after any retention interval examined in this experiment.
journal_name
Acta Neurobiol Exp (Wars)journal_title
Acta neurobiologiae experimentalisauthors
Lukaszewska I,Dławichowska Esubject
Has Abstractpub_date
1990-01-01 00:00:00pages
181-90issue
4-5eissn
0065-1400issn
1689-0035journal_volume
50pub_type
杂志文章abstract：:Transient elimination of visual stimuli (20 min darkness in the experimental chamber) did not affect the amphetamine induced stereotyped behavior and accompanied arousal in cats. It is concluded that anqhetamine stereotyped behavior in cats represents centrally initiated event of animal response to drug which is, unde...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Poly (lactide‑co‑glycolide) (PLGA) nanoparticles (NPs) are biodegradable carriers that participate in the transport of neuroprotective drugs across the blood brain barrier (BBB). Targeted brain‑derived neurotrophic factor (BDNF) delivery across the BBB could provide neuroprotection in brain injury. We tested the neuro...
journal_title：Acta neurobiologiae experimentalis
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doi：
更新日期：2020-01-01 00:00:00
abstract：:Functional interactions between serotoninergic and GABAergic systems in the vertebrate retina are largely unknown. In this study, the effects of isolated or combined stimulation of the serotonin receptors (with 100 μM serotonin) and ionotropic GABAA and GABAC receptors (with 5 mM TACA) on the electroretinographic (ERG...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2017-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
abstract：:It is well known that the fetal ethanol exposure and prenatal stress may have adverse effects on brain development. Interestingly, some morphological and functional recovery from their teratogenic effects that take place during brain maturation. However, mechanisms that underlie this recovery are not fully elucidated....
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pub_type： 杂志文章
doi：
更新日期：2019-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
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doi：
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：1974-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:There have been four major pioneers from Eastern Europe in the neuroscientific study of memory and learning: Pavlov, Bekhterev, Beritashvili and Konorski. The thinking of each evolved with the progress of neuroscientific knowledge throughout the world, and save for Pavlov, each encountered governmental opposition to t...
journal_title：Acta neurobiologiae experimentalis
pub_type： 传,历史文章,杂志文章
doi：
更新日期：2006-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:A mixture of fibrinopeptides A and B did not evoke any significant central effects when given by intraperitoneal injection, whereas it increased psychomotor activity when injected into a cerebral ventricle. The fibrinopeptides when given by intraperitoneal injection interacted with amphetamine to increase locomotor ac...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
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pub_type： 临床试验,杂志文章
doi：
更新日期：2002-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2013-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：10.21307/ane-2017-028
更新日期：2016-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
