Abstract:
:The effect of sphingosine on intracellular calcium signalling in glioma C6 cells was studied with Fura-2 video imaging technique. Sphingosine had a direct effect on changes in cytosolic Ca2+ concentration only when applied at high concentration of 100 microM, causing the cytosolic Ca2+ level to rise. However, at a much lower concentration of 15 microM sphingosine diminished calcium responses triggered by thapsigargin (a specific inhibitor of calcium pump in the endoplasmic reticulum) and ionomycin (calcium ionophore). Since responses to thapsigargin and ionomycin were blocked in Ca(2+)-free medium, we postulate that sphingosine is acting on the intracellular calcium stores. Additionally, sphingosine (at 15 microM and 100 microM) markedly decreases thapsigargin-induced sustained elevation in cytosolic Ca2+ concentration, indicating its inhibitory effect on thapsigargin-evoked Ca2+ influx. Sphingosine is a known inhibitor of protein kinase C and the involvement of this enzyme is postulated in the modulatory effects of sphingosine on intracellular calcium dynamics.
journal_name
Acta Neurobiol Exp (Wars)journal_title
Acta neurobiologiae experimentalisauthors
Sabała P,Wiktorek M,Czarny M,Chaban V,Barańska Jsubject
Has Abstractpub_date
1996-01-01 00:00:00pages
507-13issue
2eissn
0065-1400issn
1689-0035journal_volume
56pub_type
杂志文章abstract::Hypothyroidism affects neuron population dynamics in the hippocampus of the adult rat, with neuronal damage as the main feature of its effect. This effect is prevented by the blockade of NMDA receptors, which suggests that glutamatergic activity mediates cell death in this condition. Glutamate can also stimulate cell ...
journal_title:Acta neurobiologiae experimentalis
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journal_title:Acta neurobiologiae experimentalis
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abstract::All myelinated fibres along the unbranched pant of the phrenic nerve were teased and measured at regular intervals. At the proximal level, the size frequency distribution is bimodal with peaks at 2 and 7 micrometers. Fibres in most size classes exhibit a slight progressive tapering along their unbranched course in the...
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journal_title:Acta neurobiologiae experimentalis
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doi:
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journal_title:Acta neurobiologiae experimentalis
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journal_title:Acta neurobiologiae experimentalis
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