Abstract：
:Functional interactions between serotoninergic and GABAergic systems in the vertebrate retina are largely unknown. In this study, the effects of isolated or combined stimulation of the serotonin receptors (with 100 μM serotonin) and ionotropic GABAA and GABAC receptors (with 5 mM TACA) on the electroretinographic (ERG) ON (b‑wave) and OFF (d‑wave) responses were investigated in frog eyecup preparations. It was found that serotonin alone produced a significant enhancement of the b‑ and d‑wave amplitude, while TACA alone caused its marked diminution. The relative amplitude diminution, caused by the TACA treatment, was significantly smaller when TACA was applied on the background of the fully developed serotonin effect. This result suggests that the retinal serotoninergic system could diminish the effects of ionotropic GABA receptor activation on the ERG wave generator mechanisms. In order to separately evaluate the effects of the GABAC receptor activation, in a subset of experiments the effects of TACA or TACA + serotonin were tested during GABAA receptor blockade with 100 μM bicuculline. Bicuculline alone caused a marked increase of the b‑ and d‑wave amplitude. The stimulation of GABAC receptors (with TACA) during bicuculline action produced a strong diminution of the b‑ and d‑wave amplitudes. Similar relative decrease of the b‑wave amplitude was produced when TACA was applied in combination with serotonin, while the relative decrease of the d‑wave amplitude was less pronounced during treatment with serotonin + TACA than TACA alone. Our results demonstrate that there is an ON/OFF asymmetry in the receptors involved in the presumed interactions between serotoninergic and GABAergic systems. Serotonin may decrease the effects of GABAA receptor activation in the ON pathway, while it may decrease the effects of both GABAA and GABAC receptor activation in the OFF pathway.
journal_name
Acta Neurobiol Exp (Wars)journal_title
Acta neurobiologiae experimentalisauthors
Popova E,Kupenova Psubject
Has Abstractpub_date
2017-01-01 00:00:00pages
351-361issue
4eissn
0065-1400issn
1689-0035pii
7737journal_volume
77pub_type
杂志文章abstract：:As investigation has been made of the adequacy of direct current to block conduction in the myelinated fibres of the cervical vagus nerve, leaving the nonmyelinated fibres conducting normally. Conduction was assessed from the compound electroneurograms, and from single fibre recording. Conduction of spontaneous activi...
journal_title：Acta neurobiologiae experimentalis
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doi：
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更新日期：2007-01-01 00:00:00
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