Abstract：
:It is well known that the fetal ethanol exposure and prenatal stress may have adverse effects on brain development. Interestingly, some morphological and functional recovery from their teratogenic effects that take place during brain maturation. However, mechanisms that underlie this recovery are not fully elucidated. The aim of this study was to examine whether the postnatal attenuation of fetal alcohol - and maternal stress‑induced morphological and functional deficits correlates with compensatory changes in the expression/activation of the brain proteins involved in inflammation, cell survival and apoptosis. In this project, we investigated the hippocampus which belongs to the brain regions most susceptible to the adverse effects of prenatal ethanol exposure. Pregnant rat dams were administered ethanol (A) or isocaloric glucose solution (IC) by a gastric intubation during gestational days 7-20. The pure control group received ad libitum laboratory chow and water with no other treatment. The hippocampi of fetal-ethanol and control pups were examined at the postnatal day (PD)1, PD10, PD30 and PD60. Moderate fetal-ethanol exposure and prenatal intubation stress caused a significant increase in molecular factors relating to inflammation (iNOS) and cell survival/apoptosis pathways (PTEN, GSK-3 and ERK) at birth, with a rapid compensation from these developmental deficits upon removal of alcohol at PD10. Indeed, an increase in ERK1/2 and JNK1/2 activation at PD30 was observed with ethanol consumption. It indicates that the recovery process in A and IC brains started soon after the birth upon the ethanol and stressor withdrawal and continued until the adulthood.
journal_name
Acta Neurobiol Exp (Wars)journal_title
Acta neurobiologiae experimentalisauthors
Elibol B,Beker M,Sahbaz CD,Kilic U,Jakubowska-Doğru Esubject
Has Abstractpub_date
2019-01-01 00:00:00pages
133-147issue
2eissn
0065-1400issn
1689-0035pii
7912journal_volume
79pub_type
杂志文章abstract：:Ongoing unconscious processes may be influenced by related conscious processes without self-awareness. (a) When the conscious semantic interpretation of physically identical shapes changes due to their angular rotation, the sequence of saccadic movements arid the localization of eye fixations over the shapes change as...
journal_title：Acta neurobiologiae experimentalis
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更新日期：1981-01-01 00:00:00
abstract：:The changes of intertrial response (ITR) rate along the intertrial interval duration were examined in 30 rats trained in two-way avoidance. The lowest ITR rate was observed just after a cross-through response terminating a trial. Rats trained with a warning signal of darkness showed over-all higher ITR rates and short...
journal_title：Acta neurobiologiae experimentalis
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journal_title：Acta neurobiologiae experimentalis
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更新日期：1975-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
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更新日期：2002-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
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更新日期：1987-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
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更新日期：1983-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
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更新日期：2008-01-01 00:00:00
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doi：
更新日期：2012-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
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doi：
更新日期：2004-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
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doi：
更新日期：2012-01-01 00:00:00
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doi：
更新日期：2018-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
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doi：
更新日期：2009-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1974-01-01 00:00:00
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doi：
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journal_title：Acta neurobiologiae experimentalis
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doi：
更新日期：1979-01-01 00:00:00
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更新日期：1994-01-01 00:00:00
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更新日期：1981-01-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
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更新日期：1995-01-01 00:00:00
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更新日期：2014-01-01 00:00:00
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更新日期：1997-01-01 00:00:00
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更新日期：1991-01-01 00:00:00
