Abstract:
:The aim of this in vivo microdialysis study was to characterise the regulation of prostaglandin D2 (PgD2) synthesis by NMDA receptors in the rabbit hippocampus in relation to changes in extracellular Ca2+ concentration ([Ca2+]e) and nitric oxide (NO) levels. Samples of dialysate were analysed for changes in PgD2 concentration, in [Ca2+]e and in the level of NO. The results demonstrated that a 20-min pulse application of 0.1-2.5 mM NMDA via a microdialysis probe induced a prolonged stimulation of PgD2 release that was sensitive to competitive NMDA receptor antagonists. An inhibitor of voltage-sensitive Na+ channels, tetrodotoxin, did not influence this effect but significantly suppressed basal PgD2 production, whereas a NOS inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME), prevented NMDA-evoked NO release and inhibited NMDA-induced PgD2 release in an L-arginine-sensitive manner. NO donors, S-nitroso-N-acetylpenicillamine and sodium nitroprusside, stimulated PgD2 release. NMDA-evoked decrease in [Ca2+]e was insensitive to TTX and L-NAME. These results demonstrate an in vivo NMDA receptor-mediated modulation of PgD2 synthesis in the brain, in which NO participates.
journal_name
Acta Neurobiol Exp (Wars)journal_title
Acta neurobiologiae experimentalisauthors
Łazarewicz JW,Salińska E,Stafiej A,Ziembowicz A,Ziemińska Esubject
Has Abstractpub_date
2000-01-01 00:00:00pages
427-35issue
4eissn
0065-1400issn
1689-0035journal_volume
60pub_type
杂志文章abstract::During the normal course of neuronal differentiation gangliosides undergo marked changes in both quantity and quality. These changes, i.e. several-fold increase in concentration and appearance of the gangliotetraose family, have been observed both in vivo and in neuronal cell cultures. In addition to these naturally o...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章,评审
doi:
更新日期:1990-01-01 00:00:00
abstract::Various explanations of the process of conditioning and some models of the postulated connections between brain centers are discussed. Some results of research on conditioning processes at the neuronal level are reviewed. A hypothesis is put forth that conditioned behavior is a result of activation of neural patterns ...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract::Experiments were performed with anaesthetized (urethan and chloralose) spontaneously breathing rabbits. Horseradish peroxidase (HRP) was injected (1 mg) with a Hamilton syringe into the end of the sectioned mylohyoid nerve. The HRP-labelled neurones could be localized in the motor nucleus of the trigeminal nerve (N.V....
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
abstract::During paradoxical sleep electrical stimulation of the mesencephalic reticular formation and emotiogenic structures in the mesencephalon and diencephalon produced depression or an increase in the theta rhythm of the hippocampal and entorhinal electrical activity. However, stimulation not involving behavioral arousal d...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract::The pedunculopontine tegmental nucleus (PPN) is one of the reticular generators of the hippocampal theta rhythm. The PPN neuronal circuitry related to theta generation involves its cholinergic, GABA-ergic and glutamatergic components. Here we provide data indicating that the PPN tachykinin system may also be a part of...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::Data by the author, as well as from other laboratories, show residual fear as the main source of intertrial responses (ITR) during defensive instrumental training in rats, cats and dogs. Between-subject differences in ITR rate arise in the course of training. The differences depend on training conditions and on subjec...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章,评审
doi:
更新日期:1993-01-01 00:00:00
abstract::Functional interactions between serotoninergic and GABAergic systems in the vertebrate retina are largely unknown. In this study, the effects of isolated or combined stimulation of the serotonin receptors (with 100 μM serotonin) and ionotropic GABAA and GABAC receptors (with 5 mM TACA) on the electroretinographic (ERG...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2017-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::Twenty five animals trained in the left leg-right leg differentiation were given orbital, proreal or medial precruciate lesions. Pure cortical ablations did not affect the task whereas these deep lesions involving the bundle of fibers inside the prefrontal region caused severe deficit. The medial lesions (superficial ...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1972-01-01 00:00:00
abstract::Neostriatal afferents from the primary visual cortex in rats were studied using dextran-biotin, biocytin, and Fluoro-Gold. The area V1 was found to project only to a dorsomedial, longitudinal region of neostriatum (NS), bordering on the lateral ventricle and subcortical white matter. The preterminal fibres in the NS f...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Vocalization and eye movements during emotional-defensive response evoked by unilateral intrahypothalamic carbachol injections (10 micrograms) were quantitatively determined. The growling episodes duration paralleled the development and the subsiding of the defensive behavior, while the changes of eye movements indica...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::The intergeniculate leaflet (IGL) of the thalamus constitutes a small but important part of the neural network controlling circadian activity in rodents. It appears that IGL integrates photic cues from retina with non-photic information originating from different nonspecific brain systems. Subsequently, this integrate...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2015-01-01 00:00:00
abstract::Correct reaction probability and minimum exposition time in visual form discrimination task were studied under the conditions of varying pattern parameters. The minimal exposition time depended on pattern contrast and pattern background ratio and on the number of screen position variations. However, it remained unchan...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::The effect of sphingosine on intracellular calcium signalling in glioma C6 cells was studied with Fura-2 video imaging technique. Sphingosine had a direct effect on changes in cytosolic Ca2+ concentration only when applied at high concentration of 100 microM, causing the cytosolic Ca2+ level to rise. However, at a muc...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::A review of research regarding the deleterious effects of stimulus preexposure upon subsequent learning is presented. The investigations are discussed with respect both to the generality of this phenomenon and variables controlling its magnitude. Complementary experiments are suggested. Theoretical interpretations are...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章,评审
doi:
更新日期:1974-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1973-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1972-01-01 00:00:00
abstract::For years, interneurons expressing vasoactive intestinal peptide (VIP) interneurons and their function within the neocortex have been shrouded in mystery. Their relatively small size and minimal representation in the cortex have made investigation difficult. Due to their service role performed in co‑operation with gli...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2019-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::Embedment-free electron microscopy (EFEM) is a new method which allows the visualisation of cytoskeleton in whole-mounted cells. In this study we employed EFEM to investigate the structure of cellular scaffolds in glioma C6 cell line. The cells were extracted with Triton X-100 that dissolves phospholipids in the membr...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::Three types of behavior in three different groups of animals were studied: (i) water and food intake, (ii) instrumental performance reinforced by water or food, and (iii) spontaneous locomotor activity. Amygdalar rats, in comparison with control ones, revealed a transient decrease in the total amount of the unconditio...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::The effect of central, short-term melatonin administration on daily GnRH and LH secretion was studied in ewes during seasonal anestrus. Melatonin, in a total dose of 32 micrograms and the vehicle were perfused for 4 hours into the mediobasal hypothalamus/median eminence (MBH/ME). The mean GnRH concentration during per...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::A new method of investigating animal locomotion is presented which allows for the simultaneous measurement of the basic overground locomotion parameters: swing and stance durations, stride lengths, velocity of movement, gait diagrams and temporal relationships between all animal limbs. The measurements and recordings ...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract:INTRODUCTION AND METHODS:Cognitive deficits in insomnia have been already reported (5), however, a correlation between cognitive impairment and severity of insomnia was not as yet studied. Sixteen not medicated patients with primary insomnia according to DSM-IV (4), 7 men an 9 women, of mean age 40.8 year, were compare...
journal_title:Acta neurobiologiae experimentalis
pub_type: 临床试验,杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::The changes of intertrial response (ITR) rate along the intertrial interval duration were examined in 30 rats trained in two-way avoidance. The lowest ITR rate was observed just after a cross-through response terminating a trial. Rats trained with a warning signal of darkness showed over-all higher ITR rates and short...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00