Abstract：
:Mutations in the PINK1 gene are responsible for typical symptoms of Parkinson's disease. Using Drosophila melanogaster mutant PINK1B9 and after PINK1 silencing with RNAi using transgenic lines, we observed defects in synapses and behavior. The lack or reduced expression of PINK1 prolonged sleep during the day (nap) and decreased the total locomotor activity during 24 h, in addition to a decrease in climbing ability and a reduced lifespan. In the brain, PINK1 mutants had a lower level of Bruchpilot (BRP), a presynaptic scaffolding protein that is crucial for neurotransmission in all type of synapses in Drosophila. In addition, other proteins that are involved in synaptic transmission; Rab5, Syntaxin and Wishful Thinking were also decreased in abundance in mutants, except Synaptotagmin. Transmission electron microscopy (TEM) also confirmed less and abnormal synaptic vesicles at tetrad synapses in the visual system of PINK1 mutants. The lower level of BRP and longer day sleep observed was also detected in white mutants, which were examined to test the effect of the\r\nwhite background on the PINK1B9 strain. The reduced locomotor activity and longer day sleep in PINK1 mutants and after decreasing the PINK1 level in neurons seem to be correlated with a decrease in mitochondria number during the day, when they normally peak, and with impaired synaptic transmission.
journal_name
Acta Neurobiol Exp (Wars)journal_title
Acta neurobiologiae experimentalisauthors
Doktór B,Damulewicz M,Krzeptowski W,Bednarczyk B,Pyza EMsubject
Has Abstractpub_date
2018-01-01 00:00:00pages
231-241issue
3eissn
0065-1400issn
1689-0035pii
7824journal_volume
78pub_type
杂志文章abstract：:The frequency of obturator nerve damage due to pelvic diseases, fractures or gynecologic procedures is uncertain. In the present study, we investigated the effect of FK506, a potent macrolide antibiotic and immunosuppresant, on obturator nerve recovery at morphological and functional levels. Forty female Wistar rats w...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:The authors made a study of the effect of prostacyclin (PGI2) on ischemic morphological changes in the brain, extracellular calcium concentration (Ca2+e) and the blood-brain barrier (BBB) permeability. This was combined with physiological and neurophysiological measurements. Complete cerebral ischemia (CCI) lasting 15...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Adult mammalian brain contains a number of specialized neurovascular structures termed "niches" that act as sources of neuronal cells throughout the individual's life. Some of the niches generate neurons to satisfy the need for 'replacement' neurons within the same or closely located brain structures, whereas the othe...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：10.21307/ane-2017-012
更新日期：2016-01-01 00:00:00
abstract：:Anxiety is a complex psychological state which happens after stressful life experiences. Many factors such as daily life events, neurotransmitter systems, and different brain areas could influence anxiety behavior in humans and animals. For example, opioids and androgens decrease anxiety behavior both in humans and an...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
abstract：:Dorsal prefrontal lesions in dogs elicit hyperreactivity in instrumental discrimination and perseveration in trained serial action pattern. Lateral premotor injury causes hyporeactivity in instrumental discrimination and prolongation of activity in the trained serial action pattern. When the dorsal prefrontal area was...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1972-01-01 00:00:00
abstract：:The influence of bilateral injections of serotonin (5-HT) and methysergide (MET) to antero-medial hypothalamus (HA) on carbachol-induced emotional-defensive behavior was investigated. Earlier (15 min) stimulation of 5-HT receptors in HA region by 5-HT injections evoked a decrease in the level of vocal response (number...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Parkinson's disease (PD) is a common neurodegenerative disease that appears essentially as a sporadic condition. PD is well known to be a chronic and progressive neurodegenerative disease produced by a selective degeneration of dopaminergic neurons in the substantia nigra pars compacta. The main clinical features of P...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：:The mammalian pineal organ contains photoreceptor-specific proteins, whose distribution shows conspicuous variation among different species of mammals. Nevertheless, the following general conclusions can be drawn: immunoreactions for S-antigen and recoverin labeled more pinealocytes than the rod-opsin immunoreaction. ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
abstract：:In normal dogs a differentiation task consisting of lifting the left or right foreleg in response to the tactile stimuli administered to the left or right side of the body respectively is very difficult, requiring from 500 to 1,000 trials. On the contrary the same task presented to other dogs after transection of the ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Computer techniques were employed to construct a respiratory control model in which the variables treated were programmed according to a series of mathematical equations, with the purpose of eliciting the relationship of V-PCO2 (minute ventilation-partial pressure of carbon dioxide) on a transient time basis. It was d...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
abstract：:Twenty two months old and eight months old rats were used. They were submitted to object recognition test with 1 min interval between two successive presentations of the same object or two different objects. Initial exploration of the object was lower in aged than in young rats. However, both groups showed comparable ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:The mechanisms involved in avoidance behavior are discussed. It is assumed that the conditioned stimulus (CS) activates the memory pattern of associations related to the former applications of the unconditioned stimulus (US) and, as a result, produces an undesirable sensory state. This activates another memory pattern...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：1980-01-01 00:00:00
abstract：:The aim of the present study was to investigate the effect of small unilateral lesions to the ventromedial portion of the prefrontal cortex on two memory functions: memory for objects and memory for object locations. Patients, who had undergone surgery of the anterior communicating artery aneurysm, and normal control ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
abstract：:Techniques (push-pull cannula, cup, brain ventricles perfusion) allowing estimation of the amount of the ACh released in vivo from the brain are described. The main attention is paid to biochemical, physiological and morphological factors influencing the amount of ACh released and available for estimation. Conditions ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Abnormal auditory temporal processing might be an underlying deficit in language disabilities. The auditory temporal-order threshold, one measure for temporal processing abilities, is defined as the shortest time interval between two acoustic events necessary for a person to be able to identify the correct temporal or...
journal_title：Acta neurobiologiae experimentalis
pub_type： 临床试验,杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:Ongoing unconscious processes may be influenced by related conscious processes without self-awareness. (a) When the conscious semantic interpretation of physically identical shapes changes due to their angular rotation, the sequence of saccadic movements arid the localization of eye fixations over the shapes change as...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Studies were performed on 46 units of medial gastrocnemius muscles in 23 rats. In the examined population, three types of motor units were distinguished: fast fatigable (FF), fast resistant (FR) and slow (S) units. The studied muscle was stretched with force gradually increasing from 0.5 to 10 g. Most of FF units and ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:A mixture of fibrinopeptides A and B did not evoke any significant central effects when given by intraperitoneal injection, whereas it increased psychomotor activity when injected into a cerebral ventricle. The fibrinopeptides when given by intraperitoneal injection interacted with amphetamine to increase locomotor ac...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
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journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
abstract：:An autoshaping procedure, in which presentation of a retractable lever signalled food delivery, was used to assess the effects of ventral tegmental area lesions on appetitive classically conditioned responses in 28 rats. Rats with ventral tegmental area lesions did not differ from sham-lesioned rats in acquiring class...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:The purpose of the present study was to find out whether the occurrence of bursts of spontaneous spike-wave discharges (SWD) in rat neocortex is related to a particular state of vigilance (level of arousal), as some authors suggested, or rather to transitions from one state to another as postulated by others. Patterns...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:In psychophysical experiments, subjects matched two spatial intervals of a three-spot stimulus into what appeared to them to be equal. The stimulus was flanked by stripes. The length matching errors increased in proportion to the referent interval of the stimulus and approached 6-12 percent of its length. Also, the er...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:The pedunculopontine tegmental nucleus (PPN) is one of the reticular generators of the hippocampal theta rhythm. The PPN neuronal circuitry related to theta generation involves its cholinergic, GABA-ergic and glutamatergic components. Here we provide data indicating that the PPN tachykinin system may also be a part of...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Spontaneous and evoked activity of red nucleus neurons is described in chloralose anesthetized cats. It is suggested that some effects, e.g. burst discharges and prolonged inhibitory-excitatory responses, were induced by the use of chloralose. ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:Connnections of the cortical region situated in the medial and lateral walls of the presylvian fissure in the dog were investigated using the method of retrograde HRP transport. The patterns of subcortico-cortical and cortico-cortical projections sho,w that the cortical field of the medial presylvian wall (paraorbital...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
