Abstract：
:The mammalian pineal organ contains photoreceptor-specific proteins, whose distribution shows conspicuous variation among different species of mammals. Nevertheless, the following general conclusions can be drawn: immunoreactions for S-antigen and recoverin labeled more pinealocytes than the rod-opsin immunoreaction. The intensity of the recoverin- and S-antigen immunoreactions varied from cell to cell. alpha-Transducin immunoreaction was absent from the pineal organ of all mammals investigated with the exception of the blind mole rat. Immunoreaction for the cyclic GMP-gated cation channel was undetectable in the pineal organ of all mammals investigated. The functional significance of photoreceptor-specific proteins in the mammalian pineal organ remains unknown. It has been speculated that the S-antigen might be involved in adrenergic transduction mechanisms. To test this assumption, we have started to analyze calcium responses of single rat pinealocytes to norepinephrine stimulation using the Fura-2 technique. The cells were subsequently labeled by means of S-antigen immunocytochemistry. These combined investigations showed that variation in S-antigen immunoreactivity is not correlated with differences in the rapid calcium response to stimulation with norepinephrine. It remains to be determined whether cells displaying different intensities of the S-antigen immunoreaction show different cyclic AMP responses to noradrenergic stimulation. Investigations along this line should help to clarify further whether there is indeed a relation between the expression of S-antigen and noradrenergic transduction mechanisms in the mammalian pineal organ.
journal_name
Acta Neurobiol Exp (Wars)journal_title
Acta neurobiologiae experimentalisauthors
Schomerus C,Ruth P,Korf HWsubject
Has Abstractpub_date
1994-01-01 00:00:00pages
9-17eissn
0065-1400issn
1689-0035journal_volume
54 Supplpub_type
杂志文章,评审abstract：:The purpose of this review is to summarize current knowledge about the gut microbiota in neuropsychiatric disorders. It is estimated that the human gut is colonized by up to 1018 microorganisms, mostly anaerobic bacteria. The gut microbiome is responsible for multiple functions, e.g. tightness of the intestine barrier...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2018-01-01 00:00:00
abstract：:Cyto- and myeloarchitectonics as well as acetylcholinesterase activity of the nucleus limitans thalami--an important part of the nociceptive system--were studied in insectivora (Sorex araneus, Erinaceus europaeus, Talpa europaeus), rat, rabbit, cat, monkey and man. Our results suggest that nucleus limitans is phylogen...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:The intranuclear membranaceus inclusions (IMI) appear as encapsulated irregular vacuoles surrounded by a single, rarely double, membrane. The vacuoles include floccular, fine granular content or they are translucent. They were found in neurones of particularly old or very young laboratory animals. Our studies concerni...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The interaction between kinins formed in central nervous system and acetylcholine was studied. Endogenous ACh in excess acted psychodepressively on the animal's behavior as evaluated with Lat's test. This effect was more intense in those rats in which the activity of kinin-forming enzymes in the nervous tissue had bee...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:A differentiation of instrumental responses to auditory location stimuli using the Konorski Test was investigated. Each stimulus consisted of two components separated by intrastimulus interval. The components were click series presented from four loudspeakers situated in front of the animal, on horizontal and vertical...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Functional interactions between serotoninergic and GABAergic systems in the vertebrate retina are largely unknown. In this study, the effects of isolated or combined stimulation of the serotonin receptors (with 100 μM serotonin) and ionotropic GABAA and GABAC receptors (with 5 mM TACA) on the electroretinographic (ERG...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2017-01-01 00:00:00
abstract：:A new hypothesis concerning the mechanism of the P. rufescens' slave-raids, is proposed. (i) The so-called pseudo-scouting does not contribute to the slave-raids. (ii) The direction of the raid is determined by the random movement of the most easily aroused individuals - the so-called activists. (iii) Once the directi...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:The finding of stem/progenitor cells in postnatal bone marrow and umbilical cord blood, opens up a possibility of using stem cells to treat neurologic diseases. There is a controversy, whether intravenously administered human umbilical cord blood cells (HUCBC) migrate to the brain, differentiate and improve recovery a...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：:The reasons for the rise in autism prevalence are a subject of heated professional debate. Featuring a critical appraisal of some research used to question whether rising levels of autism are related to environmental exposure to toxins (Soden et al. 2007, Barbaresi et al. 2009, Thompson et al. 2007) we aim to evaluate...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:Time characteristics of lateral-hypothalamic self-stimulation were analyzed in rats using point process statistics. Inter-barpressing interval distributions were usually unimodal and asymmetrical and resembled shifted exponential distribution, i.e. bar-pressings seem to be performed more or less randomly over time. Wh...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Neostriatal afferents from the primary visual cortex in rats were studied using dextran-biotin, biocytin, and Fluoro-Gold. The area V1 was found to project only to a dorsomedial, longitudinal region of neostriatum (NS), bordering on the lateral ventricle and subcortical white matter. The preterminal fibres in the NS f...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:Autism, Asperger's syndrome (AS), and pervasive developmental disorder - not otherwise specified (PDD-NOS) compose the overall diagnostic category of autism spectrum disorder (ASD). Subjects diagnosed with an ASD have a male:female ratio of 4:1, and among subjects diagnosed with AS the male:female ratio is as high as ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2012-01-01 00:00:00
abstract：:Inherited or acquired oligodendrocyte deficiency or abnormalities usually lead to severe neurological disorders, common in humans and animals. The wide spectrum of diseases to be treated, their frequency and lack of effective treatments result in an urgent need to elaborate alternative options such as cell replacement...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：:Depolarization of cultured astrocytes by KCl stimulated gamma-aminobutyric acid (GABA) release in a dose-dependent manner. At 60 mM KCl, the stimulatory effect was calcium- and sodium- independent, and was not altered by the presence of beta-alanine. The potassium-evoked GABA release was inhibited by furosemide and 4-...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:This paper reviews studies that investigate conditions resulting in long-lasting modifications of synaptic efficacy in horizontal connections within layers II/III of adult rat motor cortex using the in vitro slice preparation. Long-term potentiation (LTP) was induced by high frequency theta burst stimulation (TBS) whe...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
abstract：:Techniques (push-pull cannula, cup, brain ventricles perfusion) allowing estimation of the amount of the ACh released in vivo from the brain are described. The main attention is paid to biochemical, physiological and morphological factors influencing the amount of ACh released and available for estimation. Conditions ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:In monkeys, cerebellar vermal cortical or fastigial nuclear lesion resulted in no significant postural asymmetry. Combined decerebration (but not bulbar pyramid section) and unilateral vermal cortical or fastigial nuclear lesion gave marked ipsilateral hyperextension and contralateral hyperflexion of limbs. Unilateral...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:The pedunculopontine tegmental nucleus (PPN) is one of the reticular generators of the hippocampal theta rhythm. The PPN neuronal circuitry related to theta generation involves its cholinergic, GABA-ergic and glutamatergic components. Here we provide data indicating that the PPN tachykinin system may also be a part of...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:A review of research regarding the deleterious effects of stimulus preexposure upon subsequent learning is presented. The investigations are discussed with respect both to the generality of this phenomenon and variables controlling its magnitude. Complementary experiments are suggested. Theoretical interpretations are...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：1974-01-01 00:00:00
abstract：:The pineal hormone melatonin is a potent free radical scavenger. In particular, it quenches what is generally considered the most toxic and damaging free radical produced in the organism, the hydroxyl radical (.OH). Melatonin production in the pineal gland declines progressively with age such that in old animals and e...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
abstract：:Poly (lactide‑co‑glycolide) (PLGA) nanoparticles (NPs) are biodegradable carriers that participate in the transport of neuroprotective drugs across the blood brain barrier (BBB). Targeted brain‑derived neurotrophic factor (BDNF) delivery across the BBB could provide neuroprotection in brain injury. We tested the neuro...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
abstract：:The effects of injections of M- and N-cholinergic blocking agents into the antero-medial hypothalamus (HM) and the midbrain central gray (GC) on the aggressive behavior of cats, evoked by microinjections of carbachol into those areas, were investigated in chronic experiments. The influence of pharmacological suppressi...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:The role of pretectum and colliculus superior in the analysis of visual information was studied. Single unit responses to visual stimuli were recorded. Several types of responses were observed, including "suppressed by contrast", "direction non-sensitive" and "direction sensitive" responses. An attempt was made to def...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1974-01-01 00:00:00
abstract：:Quercetin, one of the major flavonoids, exhibits many beneficial effects on human organism as antihistamine, antioxidant, anti-inflammatory, anticancer and antiviral drug. It is recommended as supplement of healthy diet but still the knowledge of its beneficial effect on normal cells is not satisfactory. We decided to...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:There have been four major pioneers from Eastern Europe in the neuroscientific study of memory and learning: Pavlov, Bekhterev, Beritashvili and Konorski. The thinking of each evolved with the progress of neuroscientific knowledge throughout the world, and save for Pavlov, each encountered governmental opposition to t...
journal_title：Acta neurobiologiae experimentalis
pub_type： 传,历史文章,杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:It is well-known that the cholinergic system and the muscarinic cholinergic receptors are associated with cognitive functions. Here we examined whether a non-selective muscarinic receptor antagonist scopolamine affects learning performance and/or synaptic plasticity during the memory consolidation period. Adult male W...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:This study aimed to provide a simple way to approach group differences by independent component analysis when researching functional connectivity changes of resting-state network in brain disorders. We used baseline resting state functional magnetic resonance imaging from the Alzheimer's disease neuroimaging initiativ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：10.21307/ane-2017-028
更新日期：2016-01-01 00:00:00
abstract：:The aim of this study was to investigate the influence of the GABAergic inhibitory neurones on the absolute and increment retinal sensitivity, determined be measuring b-wave threshold of frog electroretinogram (ERG). We found that GABAergic blockade by picrotoxin (PT -noncompetitive GABA antagonist) had no apparent ef...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:The intergeniculate leaflet (IGL) of the thalamus constitutes a small but important part of the neural network controlling circadian activity in rodents. It appears that IGL integrates photic cues from retina with non-photic information originating from different nonspecific brain systems. Subsequently, this integrate...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2015-01-01 00:00:00
abstract：:In normal dogs a differentiation task consisting of lifting the left or right foreleg in response to the tactile stimuli administered to the left or right side of the body respectively is very difficult, requiring from 500 to 1,000 trials. On the contrary the same task presented to other dogs after transection of the ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
