Abstract：
:The intranuclear membranaceus inclusions (IMI) appear as encapsulated irregular vacuoles surrounded by a single, rarely double, membrane. The vacuoles include floccular, fine granular content or they are translucent. They were found in neurones of particularly old or very young laboratory animals. Our studies concerning various types of intoxications and ischemia allowed to find relatively large number of such inclusions in laboratory animals. We observed them in four experimental models: (1) cyclo-phosphamide (an alkylating drug) and (2) dichlorvos (phosphoroorganic pesticide) given orally to rabbits, (3) complete ischemia also in rabbits and (4) vincristine (an antimitotic drug) given parenteraly to rats. The IMI were found much more frequently in experimental animals than in controls. We can conclude that intranuclear membranaceus inclusions do not appear to be pathognomonic for any particular etiologic factor, but this factor may influence and distort the homeostasis within nucleus.
journal_name
Acta Neurobiol Exp (Wars)journal_title
Acta neurobiologiae experimentalisauthors
Dambska M,Maślińska D,Pluta Rsubject
Has Abstractpub_date
1992-01-01 00:00:00pages
37-40issue
1eissn
0065-1400issn
1689-0035journal_volume
52pub_type
杂志文章abstract：:Stem cell therapy is a promising strategy for overcoming the limitations of current treatment methods. The modification of stem cell properties may be necessary to fully exploit their potential. Genetic engineering, with an abundance of methodology to induce gene expression in a precise and well-controllable manner, i...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2013-01-01 00:00:00
abstract：:As investigation has been made of the adequacy of direct current to block conduction in the myelinated fibres of the cervical vagus nerve, leaving the nonmyelinated fibres conducting normally. Conduction was assessed from the compound electroneurograms, and from single fibre recording. Conduction of spontaneous activi...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
abstract：:Dorsal prefrontal lesions in dogs elicit hyperreactivity in instrumental discrimination and perseveration in trained serial action pattern. Lateral premotor injury causes hyporeactivity in instrumental discrimination and prolongation of activity in the trained serial action pattern. When the dorsal prefrontal area was...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1972-01-01 00:00:00
abstract：:This paper reviews studies that investigate conditions resulting in long-lasting modifications of synaptic efficacy in horizontal connections within layers II/III of adult rat motor cortex using the in vitro slice preparation. Long-term potentiation (LTP) was induced by high frequency theta burst stimulation (TBS) whe...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
abstract：:Twenty-two rats were reared in standard conditions during the first two months of their life. Then the animals were divided into two groups exposed to different rearing conditions. Twelve animals (Group SO) were housed socially, six animals per cage, and for three weeks they were subjected to sensory stimulation in an...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:The mechanisms involved in avoidance behavior are discussed. It is assumed that the conditioned stimulus (CS) activates the memory pattern of associations related to the former applications of the unconditioned stimulus (US) and, as a result, produces an undesirable sensory state. This activates another memory pattern...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：1980-01-01 00:00:00
abstract：:We used 5 binocularly deprived cats (BD cats), 4 control cats reared also in the laboratory (C cats) and 4 cats reared in a normal environment (N cats). The cats were trained to discriminate an upward or downward-moving light spot versus a stationary spot (detection task) and then an upward versus a downward spot (dir...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:Adult mammalian brain contains a number of specialized neurovascular structures termed "niches" that act as sources of neuronal cells throughout the individual's life. Some of the niches generate neurons to satisfy the need for 'replacement' neurons within the same or closely located brain structures, whereas the othe...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：10.21307/ane-2017-012
更新日期：2016-01-01 00:00:00
abstract：:Parkinson's disease (PD) is a common neurodegenerative disease that appears essentially as a sporadic condition. PD is well known to be a chronic and progressive neurodegenerative disease produced by a selective degeneration of dopaminergic neurons in the substantia nigra pars compacta. The main clinical features of P...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：:Earlier in vivo studies conducted on freely moving and anesthetized rats demonstrated that the posterior hypothalamus (PH) comprises pathways critical for producing the synchronous hippocampal formation (HPC) theta rhythm. In addition, these findings suggested that the frequency of the HPC theta was encoded in the PH ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:The registration of the step phases and the relations between them for all of the four limbs were described in the amygdalar, rubral and funicular cats. The evident changes in motor behavior observed after damage of the amygdala and red nucleus did not result from coordination disorders. Conversely, the damage of the ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:We investigated the responses to insect prey (dead houseflies) in 24 "derivative groups" of workers of the ant Formica polyctena created by taking sets of 25 workers out of nine larger "initial groups" kept in laboratory without queens and brood during the preceding five months. In the derivative groups the ants cease...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:The evoked cardiac response (ECR) may be described as the sum of two independent response components: an initial HR deceleration (ECR1) and a slightly later acceleration (ECR2) hypothesized to reflect stimulus registration and cognitive processing load, respectively. This study investigated processing load effects in ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：:The cortex of the middle suprasylvian sulcus was removed unilaterally in cats with brain stem transected at the pretrigeminal level. The vertical following reflex was evoked by a slit of light (1 degree x 4 degrees) moving along the vertical meridian or parallel to it up to 40 degrees in the left or right hemifield. T...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Three types of behavior in three different groups of animals were studied: (i) water and food intake, (ii) instrumental performance reinforced by water or food, and (iii) spontaneous locomotor activity. Amygdalar rats, in comparison with control ones, revealed a transient decrease in the total amount of the unconditio...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:In laboratory rats an epileptic-like spontaneous neocortical activity in the form of bursts of spike and wave discharges (SWD) develops gradually with age. High incidence of the SWD episodes is accompanied by other indices characteristic of advanced age: memory disturbances and atrophic changes within basal forebrain ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:Trimethyltin, an organic compound of tin, is a potent neurotoxicant of a mechanism of action yet to be uncovered. The neuropathological findings that trimethyltin causes selective hippocampal damage with several unique features, highly reminiscent of Ammon's horn sclerosis as a final result, have raised the possibilit...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
abstract：:Recent development of neuroimaging techniques has opened new possibilities for the study of the relation between handedness and the brain functional architecture. Here we report fMRI measurements of dominant and non-dominant hand movement representation in 12 right-handed subjects using block design. We measured possi...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:Proprioceptive effects (PE) on directional hearing, i.e., sound image shifts relatively to the sound source, produced by changes in head position, were studied in their dependence on head movement type in two groups of listeners. The first group included subjects in whom horizontal head deviation to the right or to th...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:Clinical and immunopathological evidence support a potential role of inflammatory cytokines in Alzheimer's disease (AD). However, studies examining the association between cytokine gene polymorphisms and risk of developing AD yielded conflicting results. The objective of our study was to evaluate the association betwe...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:Parkin and alpha-synuclein (α-syn) are two key proteins involved in the pathophysiology of Parkinson's disease (PD). Oligomerization/aggregation and excessive secretion of α-syn contributes to PD through free radical stress, mitochondrial impairment, and synaptic dysfunction. Parkin, an E3 ubiquitin ligase, is conside...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2019-01-01 00:00:00
abstract：:The effect of sphingosine on intracellular calcium signalling in glioma C6 cells was studied with Fura-2 video imaging technique. Sphingosine had a direct effect on changes in cytosolic Ca2+ concentration only when applied at high concentration of 100 microM, causing the cytosolic Ca2+ level to rise. However, at a muc...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:New multichannel descriptors of EEG activity: complexity (omega), total power (zeta) and generalized frequency (phi) were applied to whole night sleep analysis in 11 healthy subjects. The values of omega and phi decreased systematically from waking to slow wave sleep, and increased systematically in consecutive NREM-R...
journal_title：Acta neurobiologiae experimentalis
pub_type： 临床试验,杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Due to technological advances in electrophysiology, there is renewed interest in the analysis of local field potentials recorded at many sites simultaneously. In this paper the main problems related to the analysis of LFP are presented, and recent developments in the data analysis methods are reviewed. The focus of th...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2015-01-01 00:00:00
abstract：:The purpose of this study was to determine if the contribution of a muscle to an increase in VT remained the same regardless of the chemical stimulus used to provoke the increase. In seven anaesthetized cats one phrenic nerve was transected and placed on platinum electrodes. The activity was rectified and integrated. ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
abstract：:The aim of the study was to evaluate REM sleep parameters, especially the temporal characteristics of rapid eye movement activity, in depressed patients, and to compare three different methods for scoring of REM density. The sleep of 15 nonmedicated depressed patients and 13 healthy controls was recorded during two co...
journal_title：Acta neurobiologiae experimentalis
pub_type： 临床试验,杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:Discrimination learning of instrumental responses to auditory compound stimuli was investigated in opossums using the R-no R (go-no go) differentiation. Each compound stimulus consisted of two factors: quality and location. Each correct response performed to the conditioned positive, or "safe" stimulus, was rewarded b...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Neuron transplantation is considered to be a promising therapeutic method to replace functions lost due to central nervous system (CNS) damage. However, little is known about the extent to which implanted neuron-like cells can develop into mature neurons and acquire essential properties, and especially formation of sy...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Thyroid hormones are essential for normal brain development and very important in the normal functioning of the brain. Thyroid hormones action in the adult brain has not been widely studied. The effects of adult hyperthyroidism are not as well understood as adult hypothyroidism, mainly in hippocampal granular cells. T...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:Mutations in the PINK1 gene are responsible for typical symptoms of Parkinson's disease. Using Drosophila melanogaster mutant PINK1B9 and after PINK1 silencing with RNAi using transgenic lines, we observed defects in synapses and behavior. The lack or reduced expression of PINK1 prolonged sleep during the day (nap) an...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2018-01-01 00:00:00
