Abstract：
:Recent development of neuroimaging techniques has opened new possibilities for the study of the relation between handedness and the brain functional architecture. Here we report fMRI measurements of dominant and non-dominant hand movement representation in 12 right-handed subjects using block design. We measured possible asymmetry in the total volume of activated neural tissue in the two hemispheres during simple and complex finger movements performed either with the right hand or with the left hand. Simple movements consisted in contraction/extension of the index finger and complex movements in successive finger-thumb opposition from little finger to index finger. A general predominance of left-hemisphere activation relative to right hemisphere activation was found. Increasing the complexity of the motor activity resulted in an enlargement of the volume of consistently activated areas and greater involvement of ipsilateral areas, especially in the left hemisphere. Movements of the dominant hand elicited large contralateral activation (larger than movements of the non-dominant hand) and relatively smaller ipsilateral activation. Movements of the non-dominant hand resulted in a more balanced pattern of activation in the two hemispheres, due to relatively greater ipsilateral activation. This suggests that the dominant (right) hand is controlled mainly by the contralateral (left) hemisphere, whereas the nondominant hand is controlled by both left and right hemispheres. This effect is especially apparent during execution of complex movements. The expansion of brain areas involved in motor control in the hemisphere contralateral to the dominant hand may provide neural substrate for higher efficiency and a greater motor skill repertoire of the preferred hand.
journal_name
Acta Neurobiol Exp (Wars)journal_title
Acta neurobiologiae experimentalisauthors
Gut M,Urbanik A,Forsberg L,Binder M,Rymarczyk K,Sobiecka B,Kozub J,Grabowska Asubject
Has Abstractpub_date
2007-01-01 00:00:00pages
43-51issue
1eissn
0065-1400issn
1689-0035journal_volume
67pub_type
杂志文章abstract：:Stem cell therapy is a promising strategy for overcoming the limitations of current treatment methods. The modification of stem cell properties may be necessary to fully exploit their potential. Genetic engineering, with an abundance of methodology to induce gene expression in a precise and well-controllable manner, i...
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journal_title：Acta neurobiologiae experimentalis
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journal_title：Acta neurobiologiae experimentalis
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