Abstract:
:We have studied MHC class II antigen expression and lymphocytic infiltration during dopaminergic neurone degeneration produced by intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropiridine (MPTP). Microglial activation was observed in the striatum and in the substantia nigra (SN) in this model. We noticed a marked increase of MHC class II antigen expression on microglia and T-cell recruitment in these regions after MPTP treatment. B-lymphocytes were not observed. T-cell infiltration predominantly consisted of CD8+ cells at every time point but CD4+ cells were present too. More than a half of the observed lymphocytes showed strong staining of CD44 antigen. Our findings suggest a possible immune system involvement in the pathological process following MPTP intoxication.
journal_name
Acta Neurobiol Exp (Wars)journal_title
Acta neurobiologiae experimentalisauthors
Kurkowska-Jastrzebska I,Wrońska A,Kohutnicka M,Członkowski A,Członkowska Asubject
Has Abstractpub_date
1999-01-01 00:00:00pages
1-8issue
1eissn
0065-1400issn
1689-0035journal_volume
59pub_type
杂志文章abstract::During luteolysis in sheep, episodic pulses of oxytocin (OT), contributed by the neurohypophysis and the corpus luteum (CL), stimulate uterine luteolytic pulses of prostaglandin (PG) F2 alpha via endometrial OT receptors. To distinguish relative contributions of neurohypophysial and luteal OT, ovariectomized sheep wer...
journal_title:Acta neurobiologiae experimentalis
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doi:
更新日期:1993-01-01 00:00:00
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doi:
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更新日期:2001-01-01 00:00:00
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更新日期:2004-01-01 00:00:00
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