Abstract：
:Anxiety and depression have dramatic impact on human and animal behaviors. We take an interdisciplinary approach and review the existing experimental models of anxiety and depression in order to promote further understanding of neurobiological aspects of anxiety and depression.
journal_name
Acta Neurobiol Exp (Wars)journal_title
Acta neurobiologiae experimentalisauthors
Kalueff AV,Tuohimaa Psubject
Has Abstractpub_date
2004-01-01 00:00:00pages
439-48issue
4eissn
0065-1400issn
1689-0035journal_volume
64pub_type
杂志文章,评审abstract：:Incubation of the acutely dissected rat hippocampal slices in calcium-containing media resulted in spontaneous activation-translocation of classical PKC isoforms and their subsequent (especially gamma-type) proteolytic degradation. These changes were blocked by calpain inhibitor MDL 28 170 in 100 microM concentration....
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:Correct reaction probability and minimum exposition time in visual form discrimination task were studied under the conditions of varying pattern parameters. The minimal exposition time depended on pattern contrast and pattern background ratio and on the number of screen position variations. However, it remained unchan...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:Discrimination learning of instrumental responses to auditory compound stimuli was investigated in opossums using the R-no R (go-no go) differentiation. Each compound stimulus consisted of two factors: quality and location. Each correct response performed to the conditioned positive, or "safe" stimulus, was rewarded b...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Lesions in ventromedial part of amygdala impaired neither alimentary instrumental reflexes nor food intake, but impaired predatory behavior. Lesions localized in the more dorsal and lateral part of the amygdala produced disorders in instrumental performance and food intake without changes in predatory attack. Both kin...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:Deprivation of patterned visual information, as in early onset congenital cataract patients, results in a severe impairment in global motion perception. Previously we reported a delayed maturation of the peripheral visual field representation in primary visual area 17, based on a 2-D DIGE screen for protein expression...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2017-01-01 00:00:00
abstract：:Various explanations of the process of conditioning and some models of the postulated connections between brain centers are discussed. Some results of research on conditioning processes at the neuronal level are reviewed. A hypothesis is put forth that conditioned behavior is a result of activation of neural patterns ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:Sham operated controls and four groups of rats subjected to ablation of various parts of their frontal cortex were compared in food and water intake and four behavioural tasks. The ablations were aimed at removing (1) the ventral prefrontal cortex, (2) the dorsal part of the medial prefrontal cortex, (3) the total med...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Rats with electrolytic lesions of the nucleus basalis magnocellularis were compared to sham-lesioned rats in the retention of a continuously reinforced lever-pressing response and in the acquisition and reversal of a visual discrimination task. The muscarinic agonist pilocarpine, in conjunction with the peripheral mus...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:It is well-known that the cholinergic system and the muscarinic cholinergic receptors are associated with cognitive functions. Here we examined whether a non-selective muscarinic receptor antagonist scopolamine affects learning performance and/or synaptic plasticity during the memory consolidation period. Adult male W...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:In laboratory rats an epileptic-like spontaneous neocortical activity in the form of bursts of spike and wave discharges (SWD) develops gradually with age. High incidence of the SWD episodes is accompanied by other indices characteristic of advanced age: memory disturbances and atrophic changes within basal forebrain ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:Time characteristics of lateral-hypothalamic self-stimulation were analyzed in rats using point process statistics. Inter-barpressing interval distributions were usually unimodal and asymmetrical and resembled shifted exponential distribution, i.e. bar-pressings seem to be performed more or less randomly over time. Wh...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:In the present communication, a possible role of perceptual displacements of stimulus elements in the occurrence of visual illusions of extent has been considered. In psychophysical experiments with a single set of Müller-Lyer wings, subjects were asked to place an imaginary reference rectangle into a position that ma...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：:Depolarization of cultured astrocytes by KCl stimulated gamma-aminobutyric acid (GABA) release in a dose-dependent manner. At 60 mM KCl, the stimulatory effect was calcium- and sodium- independent, and was not altered by the presence of beta-alanine. The potassium-evoked GABA release was inhibited by furosemide and 4-...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:The authors made a study of the effect of prostacyclin (PGI2) on ischemic morphological changes in the brain, extracellular calcium concentration (Ca2+e) and the blood-brain barrier (BBB) permeability. This was combined with physiological and neurophysiological measurements. Complete cerebral ischemia (CCI) lasting 15...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:This mini review gives a brief overview over the oxidation mechanism of methionine (Met), relevant for processes which may lead to the oxidation of amyloid beta-peptide (betaAP), involved in the pathogenesis of Alzheimer's disease. The Cu(II) -catalysed oxidation of C-terminal Met35 in betaAP depends on the secondary ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2003-01-01 00:00:00
abstract：:The hippocampal EEG activity was recorded in male rats during the response-contingent reinforcement of a female. The instrumental response was a bar-pressing on a fixed-ratio-10 reinforcement schedule. The frequency of bar-pressing tends to increase during the succeeding copulatory series. The similar phenomenon was o...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Normal cats were bilaterally vagotomized at cardiac level and submitted to a classical defensive conditioning using excitatory, inhibitory and differential stimuli. That group was compared with a normal one. Both groups showed an anticipatory bradycardia to the noxious excitatory stimulus and a late deceleration to th...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:Temporal information processing controls many aspects of human mental activity and may be assessed by examining perception of temporal order in the tens of milliseconds time range. Although existing studies suggest an age-related decline in mental abilities, the data on the deterioration of temporal order perception s...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:The purpose of this study was to determine if the contribution of a muscle to an increase in VT remained the same regardless of the chemical stimulus used to provoke the increase. In seven anaesthetized cats one phrenic nerve was transected and placed on platinum electrodes. The activity was rectified and integrated. ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
abstract：:The term reflex is used in its widest sense and denotes the neural processes and effector responses controlled by the evoking stimulus and the feedback stimuli. The reflexes having their specific component facilitated by drive central processes are denoted as higher. Escape, avoidance and approach higher reflexes are ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1972-01-01 00:00:00
abstract：:The aim of the study was to evaluate REM sleep parameters, especially the temporal characteristics of rapid eye movement activity, in depressed patients, and to compare three different methods for scoring of REM density. The sleep of 15 nonmedicated depressed patients and 13 healthy controls was recorded during two co...
journal_title：Acta neurobiologiae experimentalis
pub_type： 临床试验,杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:The effect of central, short-term melatonin administration on daily GnRH and LH secretion was studied in ewes during seasonal anestrus. Melatonin, in a total dose of 32 micrograms and the vehicle were perfused for 4 hours into the mediobasal hypothalamus/median eminence (MBH/ME). The mean GnRH concentration during per...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:In the filled-space (or Oppel-Kundt) illusion, the filled part of the stimulus for most observers appears longer in comparison with the empty one. In the first two experimental series of the present study, we investigated the illusory effect as a function of continuous filling (by a shaft-line segment) of the referenc...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：10.21307/ane-2017-048
更新日期：2017-01-01 00:00:00
abstract：:The involvement of calcium ions in mechanisms of ischemic brain injury has been suggested for several years. Our understanding of the role of intracellular Ca2+ as a trigger of acute neurotoxicity and in the induction of long lasting processes leading to necrotic and/or apoptotic postischemic delayed neuronal death or...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
abstract：:The performance of well established avoidance response was tested in cats with developed, kindled, bioelectric hippocampal epileptic focus and complex partial and secondarily generalized seizures. The animals were trained before kindling to perform foreleg movement in response to clicks (conditioning stimulus) in orde...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:The pineal hormone melatonin is a potent free radical scavenger. In particular, it quenches what is generally considered the most toxic and damaging free radical produced in the organism, the hydroxyl radical (.OH). Melatonin production in the pineal gland declines progressively with age such that in old animals and e...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
abstract：:Twenty five animals trained in the left leg-right leg differentiation were given orbital, proreal or medial precruciate lesions. Pure cortical ablations did not affect the task whereas these deep lesions involving the bundle of fibers inside the prefrontal region caused severe deficit. The medial lesions (superficial ...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1972-01-01 00:00:00
abstract：:The experiment concerned the functional specialization of brain hemispheres in recognizing faces expressing emotions in patients with focal brain damage of the left and right hemispheres and in persons without damage of the central nervous system. Three types of faces were presented: happy i.e. expressing positive emo...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:The aim of this in vivo microdialysis study was to characterise the regulation of prostaglandin D2 (PgD2) synthesis by NMDA receptors in the rabbit hippocampus in relation to changes in extracellular Ca2+ concentration ([Ca2+]e) and nitric oxide (NO) levels. Samples of dialysate were analysed for changes in PgD2 conce...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:The mechanisms involved in avoidance behavior are discussed. It is assumed that the conditioned stimulus (CS) activates the memory pattern of associations related to the former applications of the unconditioned stimulus (US) and, as a result, produces an undesirable sensory state. This activates another memory pattern...
journal_title：Acta neurobiologiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：1980-01-01 00:00:00
