Abstract:
:Partial deafferentation of the hippocampus due to trimethyltin (TMT) intoxication has been reported to induce plastic rearrangements of neuronal elements but the factors that direct these responses are unknown. To assess the possible involvement of nerve growth factor (NGF) in the phenomenon we evaluated the presumable changes in the expression pattern of NGF immunoreactivity (NGF-IR) in rat hippocampus 21 days after administration of TMT (8 mg/kg, i.p.) when reactive changes are fully developed. Immunolabelling for TrkA known to mediate biological effects of NGF and for GFAP to identify astroglial cells as a one of presumed source of postinjury produced factors was carried out on adjacent sections to establish the relation between expression of these proteins. In control hippocampus NGF-IR and TrkA-IR were localized in neurons and/or neuropil. After exposure to TMT remarkable non-neuronal expression of both proteins was observed. The distribution pattern of NGF, TrkA and GFAP overlapped suggesting that reactive astrocytes may not only produce NGF but also may become responsive to this neurotrophin. Zones of extensive NGF and TrkA astroglial expression corresponded to areas of axonal-dendritic rearrangements reported earlier. The data suggest that astroglia-derived trophic activity may be involved in neuronal plastic events associated with treatment with TMT.
journal_name
Acta Neurobiol Exp (Wars)journal_title
Acta neurobiologiae experimentalisauthors
Koczyk D,Skup M,Zaremba M,Oderfeld-Nowak Bsubject
Has Abstractpub_date
1996-01-01 00:00:00pages
237-41issue
1eissn
0065-1400issn
1689-0035journal_volume
56pub_type
杂志文章abstract::Food CSs, presented (i) concomitantly with SD controlling bar pressing for food, or (ii) on the background of non-discriminated bar pressing (FR 1/15), suppress instrumental performance but elicit undiminished conditioned salivation. This result supports Soltysik-Konorski's model of CNS mechanism controlling food-orie...
journal_title:Acta neurobiologiae experimentalis
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journal_title:Acta neurobiologiae experimentalis
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journal_title:Acta neurobiologiae experimentalis
pub_type: 临床试验,杂志文章
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更新日期:1998-01-01 00:00:00
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更新日期:1985-01-01 00:00:00
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更新日期:2009-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
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更新日期:2013-01-01 00:00:00
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更新日期:2011-01-01 00:00:00
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更新日期:1996-01-01 00:00:00
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doi:
更新日期:1986-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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更新日期:1978-01-01 00:00:00
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更新日期:1996-01-01 00:00:00
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