Novel Therapies for Pemphigus Vulgaris.

abstract：:Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily that regulate lipid, glucose, and amino acid metabolism. More recently, PPARs and corresponding ligands have been shown in skin and other organs to regulate important cellular functions, including cell proliferation and...

journal_title：American journal of clinical dermatology

authors： Sertznig P,Seifert M,Tilgen W,Reichrath J

更新日期：2008-01-01 00:00:00

abstract：:Erythema annulare centrifugum is a reactive erythema of various possible etiologies including, although less often, an associated cancer. Cancer-related erythema annulare centrifugum is most commonly associated with lymphoproliferative malignancies, specifically lymphoma and leukemia. Malignancy-associated erythema an...

journal_title：American journal of clinical dermatology

authors： Chodkiewicz HM,Cohen PR

更新日期：2012-08-01 00:00:00

abstract：:For nearly 50 years, thalidomide has struggled between success and controversy. After causing an epidemic of phocomelia and other birth defects during the 1960s, affecting thousands of neonates, thalidomide was used as a sedative in selective disorders including leprosy. The potent anti-inflammatory properties of thal...

journal_title：American journal of clinical dermatology

authors： Pelle MT,Werth VP

更新日期：2003-01-01 00:00:00

abstract：:Chronic venous insufficiency (CVI) occurs in a relatively large proportion of the population and is associated with significant morbidity, high cost of healthcare, loss of productivity and reduced quality of life. Lower extremity ulcers related to CVI have been estimated to affect 0.2-1% of the population in developed...

journal_title：American journal of clinical dermatology

authors： Simka M,Majewski E

更新日期：2003-01-01 00:00:00

abstract：:Topical therapy is one of the foundations of dermatology. The vehicles used to deliver topical therapy have considerable impact on efficacy. The vehicle can have direct effects on disease; it can impact the delivery of the active drug, and its characteristics affect patient compliance. While the physical chemistry of ...

journal_title：American journal of clinical dermatology

authors： Feldman SR,Housman TS

更新日期：2003-01-01 00:00:00

abstract：:The treatment of cutaneous T cell lymphoma (CTCL), which includes mycosis fungoides and Sezary syndrome, has been in a state of continual change over recent decades, as new therapies are constantly emerging in the search for more effective treatments for the disease. However, prognosis and survival of patients with CT...

journal_title：American journal of clinical dermatology

authors： Apisarnthanarax N,Talpur R,Duvic M

更新日期：2002-01-01 00:00:00

abstract：:Vitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproductive diseases, infections, and autoimmune and dermatological disorders. The two main sources of vitamin D are sun exposure and oral intake, including vitamin D supplementation and dietary intake. Mult...

journal_title：American journal of clinical dermatology

authors： Kechichian E,Ezzedine K

更新日期：2018-04-01 00:00:00

abstract：:As psoriasis and psoriatic arthritis are chronic in nature, ideal treatment should have sustained efficacy, with minimal short- and long-term toxicities to allow lifelong treatment. Traditional therapies used for psoriatic arthritis or psoriasis, including phototherapies and systemic agents, do not satisfy these crite...

journal_title：American journal of clinical dermatology

authors： Lebwohl MG

更新日期：2005-01-01 00:00:00

abstract：:Solar, and particularly UV, radiation causes molecular and cellular damage with resultant histopathologic and clinical degenerative changes, leading in turn to photosensitivity, photo-aging, and skin cancer. While our bodies have some natural UV defenses, additional protection from the sun is essential, including sun ...

journal_title：American journal of clinical dermatology

authors： Gonzaga ER

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:A few studies in psoriasis vulgaris patients have reported changes suggesting red blood cell (RBC) damage is linked to neutrophil activation, oxidative stress, and psoriasis worsening. OBJECTIVE:The aim of this study was to evaluate erythroid disturbances in Portuguese psoriasis vulgaris patients, before, d...

journal_title：American journal of clinical dermatology

authors： Coimbra S,Oliveira H,Reis F,Belo L,Rocha S,Quintanilha A,Figueiredo A,Teixeira F,Castro E,Rocha-Pereira P,Santos-Silva A

更新日期：2012-02-01 00:00:00

abstract：SIGNIFICANCE:Psoriasis, a common immune-mediated disease, affects approximately 2% of the population worldwide. Sudden sensorineural hearing loss (SSNHL) might be a manifestation of systemic vascular involvement in autoimmune disease. However, to the best of our knowledge, there is no systematic English-language examin...

journal_title：American journal of clinical dermatology

authors： Yen YC,Lin YS,Weng SF,Lai FJ

更新日期：2015-06-01 00:00:00

abstract：:Halobetasol propionate (HP) 0.5% ointment and cream are class I topical corticosteroids. We review the efficacy and tolerability of HP for treatment of plaque psoriasis in the English language literature. The efficacy of HP ointment and cream is consistently superior to other super-potent topical corticosteroids. Loca...

journal_title：American journal of clinical dermatology

authors： Rivera AM,Hsu S

更新日期：2005-01-01 00:00:00

abstract：:Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that may be caused by an adverse drug reaction. We discuss the clinical presentation and outcomes of 52 cases of drug-induced PG reported to date in the literature. We conducted our literature search for case reports of drug-induced PG using keywords on PubMe...

journal_title：American journal of clinical dermatology

authors： Wang JY,French LE,Shear NH,Amiri A,Alavi A

更新日期：2018-02-01 00:00:00

abstract：:Erythema nodosum (EN) is the most common form of panniculitis. It is characterized by erythematous, raised, tender nodules that usually occur bilaterally on the extensor surfaces of the lower extremities. EN is associated with many underlying conditions including infection, sarcoidosis, malignancy, and pregnancy. Its ...

journal_title：American journal of clinical dermatology

authors： Acosta KA,Haver MC,Kelly B

更新日期：2013-06-01 00:00:00

abstract：:At least 20 clinically relevant factors affect percutaneous absorption of drugs and chemicals: relevant physico-chemical properties, vehicle/formulation, drug exposure conditions (dose, duration, surface area, exposure frequency), skin appendages (hair follicles, glands) as sub-anatomical pathways, skin application si...

journal_title：American journal of clinical dermatology

authors： Law RM,Ngo MA,Maibach HI

更新日期：2020-02-01 00:00:00

abstract：:Diagnosing acne is easy. However, treatment must be adapted to the type and severity of acne, and must also take into account the impact of acne on patients' quality of life. As there is not always a correlation between the severity of acne and its impact on quality of life, it can be helpful for the dermatologist to ...

journal_title：American journal of clinical dermatology

authors： Dréno B

更新日期：2006-01-01 00:00:00

abstract：:Topical pimecrolimus 1% cream (Elidel) [hereafter referred to as topical pimecrolimus] is a nonsteroidal alternative in the treatment of pediatric atopic dermatitis. In vehicle-controlled, short-term, continuous-use trials in pediatric patients with mild to moderate atopic dermatitis, topical pimecrolimus was effectiv...

journal_title：American journal of clinical dermatology

authors： Yang LP,Curran MP

更新日期：2010-01-01 00:00:00

abstract：:Autoimmune bullous diseases (AIBD), including pemphigus, bullous pemphigoid, epidermolysis bullosa acquisita, mucous membrane pemphigoid, and pemphigoid gestationis, pose significant therapeutic challenges, especially in pregnant and post-partum breastfeeding patients or those planning to conceive. Data on the safety ...

journal_title：American journal of clinical dermatology

authors： Kushner CJ,Concha JSS,Werth VP

更新日期：2018-06-01 00:00:00

abstract：:The dermis normally directs all phases of skin wound healing following tissue trauma or disease. However, in chronic wounds, the dermal matrix is insufficient to stimulate healing and assistance by external factors is needed for wound closure. Although the concept of the extracellular matrix directing wound healing is...

journal_title：American journal of clinical dermatology

authors： Hodde JP,Johnson CE

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Confluent and reticulate papillomatosis of Gougerot and Carteaud (CRP) is a rare dermatological condition, which has not been reported widely in Asian populations. AIM:To characterize the clinicopathological and diagnostic features of CRP in a South-East Asian population. METHODS:The medical records of 29 ...

journal_title：American journal of clinical dermatology

authors： Huang W,Ong G,Chong WS

更新日期：2015-04-01 00:00:00

abstract：:Chronic itch is a common skin manifestation in many connective tissue diseases. However, the cause of chronic itch in these diseases is still not fully understood. The complex, and in some cases incomplete understanding of, pathogenesis in each condition makes it difficult to target specific mediators of chronic itch....

journal_title：American journal of clinical dermatology

authors： Haber JS,Valdes-Rodriguez R,Yosipovitch G

更新日期：2016-10-01 00:00:00

abstract：:Long-term corticosteroid treatment is the most common secondary cause of bone loss. Patients treated with long-term corticosteroid therapy may develop osteopenia or osteoporosis, and many have fractures. It is difficult to predict which corticosteroid-treated patients will develop significant skeletal complications be...

journal_title：American journal of clinical dermatology

authors： Clarke BL

更新日期：2012-06-01 00:00:00

abstract：:Recent advances in our understanding of the pathophysiology of atopic dermatitis (AD) have revealed that skin microbiome dysbiosis plays an important role in the disease. In this review, we describe how changes in the structure and function of the microbiome are involved in the pathogenesis of AD. We highlight recent ...

journal_title：American journal of clinical dermatology

authors： Li W,Yosipovitch G

更新日期：2020-09-01 00:00:00

abstract：:The Asian patient with Fitzpatrick skin types III-V is rarely highlighted in publications on cutaneous disorders or cutaneous laser surgery. However, with changing demographics, Asians will become an increasingly important group in this context. Although high melanin content confers better photoprotection, photodamage...

journal_title：American journal of clinical dermatology

authors： Ho SG,Chan HH

更新日期：2009-01-01 00:00:00

abstract：:Genital herpes, an incurable viral disease that can have a devastating impact on affected patients, is a serious public health concern affecting one in four Americans. Episodic treatment with nucleoside analogs for 3-5 days is the most common method of treatment; however, since maximum viral replication occurs within ...

journal_title：American journal of clinical dermatology

authors： Tyring S,Berger T,Yen-Moore A,Tharp M,Hamed K

更新日期：2006-01-01 00:00:00

abstract：:Aging of the skin is associated with skin thinning, atrophy, dryness, wrinkling, and delayed wound healing. These undesirable aging effects are exacerbated by declining estrogen levels in postmenopausal women. With the rise in interest in long-term postmenopausal skin management, studies on the restorative benefits th...

journal_title：American journal of clinical dermatology

authors： Shu YY,Maibach HI

更新日期：2011-10-01 00:00:00

abstract：:The family of toll-like receptors (TLRs) plays a central role in the cutaneous immune defense system. To date, different TLRs have been found on several major cell populations of the skin, such as keratinocytes, fibroblasts, antigen-presenting cells, and melanocytes. Activation of TLRs leads, via different intracellul...

journal_title：American journal of clinical dermatology

authors： Terhorst D,Kalali BN,Ollert M,Ring J,Mempel M

更新日期：2010-01-01 00:00:00

abstract：:Aggressive digital papillary adenocarcinoma (ADPAC) is a rare cutaneous malignant tumor. We report on a 42-year-old man presenting with a nontender firm nodule on his right thumb that had been present for 3 years. The lesion clinically resembled an acquired digital fibrokeratoma, but was found to be an ADPAC after pat...

journal_title：American journal of clinical dermatology

authors： Chi CC,Kuo TT,Wang SH

更新日期：2007-01-01 00:00:00

abstract：:Coccidioidomycosis is an endemic mycosis of the southern United States, Northern Mexico, and South America. Primary cutaneous coccidioidomycosis, despite being a very rare clinical presentation, has shown an increasing incidence. An extensive literature search for cutaneous coccidioidomycosis cases was performed using...

journal_title：American journal of clinical dermatology

authors： Reyna-Rodríguez IL,Ocampo-Candiani J,Chavez-Alvarez S

更新日期：2020-10-01 00:00:00

abstract：:In monosymptomatic hypochondriacal psychosis (MHP), such as delusional infestation (DI), the patient has a fixed, false, encapsulated belief associated with tactile hallucinations (TH), most commonly formication, which is defined as cutaneous sensations of crawling, stinging, biting, etc., without evidence of infestat...

journal_title：American journal of clinical dermatology

authors： Nakamura M,Koo J

更新日期：2016-12-01 00:00:00