Novel Therapies for Pemphigus Vulgaris.

abstract：:As psoriasis and psoriatic arthritis are chronic in nature, ideal treatment should have sustained efficacy, with minimal short- and long-term toxicities to allow lifelong treatment. Traditional therapies used for psoriatic arthritis or psoriasis, including phototherapies and systemic agents, do not satisfy these crite...

journal_title：American journal of clinical dermatology

authors： Lebwohl MG

更新日期：2005-01-01 00:00:00

abstract：:Tumor necrosis factor (TNF)-α inhibitors are an alternative to oral systemic therapies for psoriasis. Data regarding the safety of TNF-α inhibitors from randomized clinical trials may not fully reflect the effects on the clinic patient population receiving the therapy, but other sources of information are available. W...

journal_title：American journal of clinical dermatology

authors： Semble AL,Davis SA,Feldman SR

更新日期：2014-02-01 00:00:00

abstract：:We report a 47-year-old man with Wilson disease who developed bullous lesions on the trunk and extremities after 20 years of penicillamine treatment. The histologic and immunofluorescence findings were diagnostic of bullous pemphigoid. When penicillamine was replaced by zinc sulfate, the patient's bullous skin lesions...

journal_title：American journal of clinical dermatology

authors： Popadic S,Skiljevic D,Medenica L

更新日期：2009-01-01 00:00:00

abstract：:Superficial mycoses are becoming increasingly resistant to current antifungal medications. As alternative therapeutic options are limited, the increasing frequency of reports of antifungal resistance is alarming. This epidemic parallels the rise of antibiotic resistance; however, the significance of this problem has y...

journal_title：American journal of clinical dermatology

authors： Gupta AK,Renaud HJ,Quinlan EM,Shear NH,Piguet V

更新日期：2020-12-22 00:00:00

abstract：:Rituximab is a chimeric monoclonal antibody that selectively binds to the CD20 molecule on B cells, resulting in their lysis. In autoimmune blistering diseases, the auto-antibody-producing B cells are destroyed and auto-antibody levels are reduced or eliminated. In the majority of patients, rituximab produces rapid cl...

journal_title：American journal of clinical dermatology

authors： Ahmed AR,Shetty S

更新日期：2015-06-01 00:00:00

abstract：:We report a typical case of hematidrosis in a Chinese girl who had experienced frequent bleeding episodes for more than 3 years. During hospitalization, spontaneous bleeding from her intact skin was witnessed by our staff on more than 20 occasions. Characteristically, bloody droplets from the intact skin contained all...

journal_title：American journal of clinical dermatology

authors： Wang Z,Yu Z,Su J,Cao L,Zhao X,Bai X,Zhan S,Wu T,Jin L,Zhou P,Ruan C

更新日期：2010-12-01 00:00:00

abstract：:This review summarizes results from major recent trials regarding novel therapeutic agents in melanoma. The topics discussed include targeted therapy with BRAF (V-RAF murine sarcoma viral oncogene homolog B) inhibitors (vemurafenib and dabrafenib), MEK (mitogen-activated protein kinase kinase) inhibitors (trametinib),...

journal_title：American journal of clinical dermatology

authors： Karimkhani C,Gonzalez R,Dellavalle RP

更新日期：2014-08-01 00:00:00

abstract：:Skin disorders are the most common adverse reactions attributed to drugs. Any skin disorder can be imitated, induced or aggravated by drugs. To help you keep up-to-date with the very latest skin reactions occurring with both new and established drugs, this section of the journal brings you information selected from th...

journal_title：American journal of clinical dermatology

authors：

更新日期：2003-01-01 00:00:00

abstract：:The treatment of cutaneous T cell lymphoma (CTCL), which includes mycosis fungoides and Sezary syndrome, has been in a state of continual change over recent decades, as new therapies are constantly emerging in the search for more effective treatments for the disease. However, prognosis and survival of patients with CT...

journal_title：American journal of clinical dermatology

authors： Apisarnthanarax N,Talpur R,Duvic M

更新日期：2002-01-01 00:00:00

abstract：:Solar, and particularly UV, radiation causes molecular and cellular damage with resultant histopathologic and clinical degenerative changes, leading in turn to photosensitivity, photo-aging, and skin cancer. While our bodies have some natural UV defenses, additional protection from the sun is essential, including sun ...

journal_title：American journal of clinical dermatology

authors： Gonzaga ER

更新日期：2009-01-01 00:00:00

abstract：:Vitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproductive diseases, infections, and autoimmune and dermatological disorders. The two main sources of vitamin D are sun exposure and oral intake, including vitamin D supplementation and dietary intake. Mult...

journal_title：American journal of clinical dermatology

authors： Kechichian E,Ezzedine K

更新日期：2018-04-01 00:00:00

abstract：:In women, acne can be successfully treated with oral contraceptives. This article focuses on the results of clinical studies on the treatment of acne with oral contraceptives. From the literature, 12 such studies could be traced over the last 10 years. Most of the studies were multicenter, randomized, and double blind...

journal_title：American journal of clinical dermatology

authors： van Vloten WA,Sigurdsson V

更新日期：2004-01-01 00:00:00

abstract：:Mycobacterial organisms have re-emerged as an important cause of infectious disease worldwide. Both tuberculosis and nontuberculous mycobacterial infections remain endemic in many parts of the world and are becoming more common in patients with iatrogenic immunosuppression and HIV infection. The nontuberculous mycobac...

journal_title：American journal of clinical dermatology

authors： Elston D

更新日期：2009-01-01 00:00:00

abstract：:Autoimmune bullous diseases (AIBD), including pemphigus, bullous pemphigoid, epidermolysis bullosa acquisita, mucous membrane pemphigoid, and pemphigoid gestationis, pose significant therapeutic challenges, especially in pregnant and post-partum breastfeeding patients or those planning to conceive. Data on the safety ...

journal_title：American journal of clinical dermatology

authors： Kushner CJ,Concha JSS,Werth VP

更新日期：2018-06-01 00:00:00

abstract：:Skin disorders are the most common adverse reactions attributed to drugs. Any skin disorder can be imitated, induced or aggravated by drugs. To help you keep up-to-date with the very latest skin reactions occurring with both new and established drugs, this section of the journal brings you information selected from th...

journal_title：American journal of clinical dermatology

authors：

更新日期：2003-01-01 00:00:00

abstract：:The solar radiation range has harmful and beneficial effects. Sunscreens, which selectively block specific spectral regions, may potentially interfere with skin homeostasis. For instance, the ultraviolet (UV) B waveband produces erythema and DNA damage; simultaneously, it induces pre-vitamin D3 synthesis. UVA1 and vis...

journal_title：American journal of clinical dermatology

authors： Stengel F

更新日期：2018-11-01 00:00:00

abstract：:The Asian patient with Fitzpatrick skin types III-V is rarely highlighted in publications on cutaneous disorders or cutaneous laser surgery. However, with changing demographics, Asians will become an increasingly important group in this context. Although high melanin content confers better photoprotection, photodamage...

journal_title：American journal of clinical dermatology

authors： Ho SG,Chan HH

更新日期：2009-01-01 00:00:00

abstract：:Superficial fungal infections are chronic and recurring conditions. Tinea capitis is a scalp infection, primarily affecting prepubescent children. Ringworm infections, such as tinea corporis and tinea cruris, involve the glabrous skin. Tinea nigra is a rare mycotic infection that may be related to travel abroad. Piedr...

journal_title：American journal of clinical dermatology

authors： Gupta AK,Cooper EA,Ryder JE,Nicol KA,Chow M,Chaudhry MM

更新日期：2004-01-01 00:00:00

abstract：:The objective of this article is to provide a brief, but critical, overview of the evidence related to complementary/alternative medicine (CAM) use, and to offer valid and useful information for dermatologists in clinical practice. Systematic literature searches were conducted on these databases: Medline, EMBASE, The ...

journal_title：American journal of clinical dermatology

authors： Ernst E,Pittler MH,Stevinson C

更新日期：2002-01-01 00:00:00

abstract：:Ocular diseases associated with atopic dermatitis (AD) may be sight-threatening. A general understanding of the pathophysiology, diagnosis, and treatment of atopic eye disease may assist dermatologists in knowing when to refer to ophthalmology and in co-managing these diseases with ophthalmologists. Ocular diseases as...

journal_title：American journal of clinical dermatology

authors： Beck KM,Seitzman GD,Yang EJ,Sanchez IM,Liao W

更新日期：2019-12-01 00:00:00

abstract：:Occupational contact dermatitis (OCD) represents 90 to 95% of all occupational dermatoses. The incidence rate of OCD is estimated to be around 0.5 to 1.9 cases per full-time worker per year. However, epidemiologic data are lacking and incidence is probably underestimated, especially in the US. Over the past 20 years, ...

journal_title：American journal of clinical dermatology

authors： Koch P

更新日期：2001-01-01 00:00:00

abstract：:Alopecia areata (AA) is non-scarring hair loss resulting from an autoimmune disorder. Severity varies from patchy hair loss that often spontaneously resolves to severe and chronic cases that can progress to total loss of scalp and body hair. Many treatments are available; however, the efficacy of these treatments has ...

journal_title：American journal of clinical dermatology

authors： Gupta AK,Carviel J,Abramovits W

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Cutaneous lichen planus (CLP) is an inflammatory dermatosis. Its chronic relapsing course and frequently spontaneous regression hamper the assessment of treatment effectiveness. OBJECTIVE:To evaluate the efficacy of available treatment modalities for CLP. DATA SOURCES:PubMed, Cochrane Central Register of C...

journal_title：American journal of clinical dermatology

authors： Atzmony L,Reiter O,Hodak E,Gdalevich M,Mimouni D

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Based on the results of numerous preclinical and clinical studies, sertaconazole can be considered a safe and effective drug for the treatment of fungal skin infections. OBJECTIVE:The objective of the study was to compare the efficacy of a solution containing 2% sertaconazole with the well established 2% se...

journal_title：American journal of clinical dermatology

authors： Borelli C,Klövekorn G,Ernst TM,Bödeker RH,Korting HC,Neumeister C

更新日期：2007-01-01 00:00:00

abstract：:Darier's disease is a rare cutaneous disease with an autosomal dominant mode of inheritance. Greasy papules and plaques arise on the seborrheic areas and in the flexures and almost all patients have nail abnormalities. Acantholysis and dyskeratosis are the typical histological findings. The underlying defect is a resu...

journal_title：American journal of clinical dermatology

authors： Cooper SM,Burge SM

更新日期：2003-01-01 00:00:00

abstract：SIGNIFICANCE:Psoriasis, a common immune-mediated disease, affects approximately 2% of the population worldwide. Sudden sensorineural hearing loss (SSNHL) might be a manifestation of systemic vascular involvement in autoimmune disease. However, to the best of our knowledge, there is no systematic English-language examin...

journal_title：American journal of clinical dermatology

authors： Yen YC,Lin YS,Weng SF,Lai FJ

更新日期：2015-06-01 00:00:00

abstract：:Recent advances in our understanding of the pathophysiology of atopic dermatitis (AD) have revealed that skin microbiome dysbiosis plays an important role in the disease. In this review, we describe how changes in the structure and function of the microbiome are involved in the pathogenesis of AD. We highlight recent ...

journal_title：American journal of clinical dermatology

authors： Li W,Yosipovitch G

更新日期：2020-09-01 00:00:00

abstract：:Itch, also known as pruritus, is the major symptom in skin diseases with a variety of etiologies and pathophysiologies. Significant progress has been achieved in understanding the pathophysiology of itch in the last 5 years. Neurophysiological experiments in humans and animals have revealed that itch is carried by spe...

journal_title：American journal of clinical dermatology

authors： Yosipovitch G,Fleischer A

更新日期：2003-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily that regulate lipid, glucose, and amino acid metabolism. More recently, PPARs and corresponding ligands have been shown in skin and other organs to regulate important cellular functions, including cell proliferation and...

journal_title：American journal of clinical dermatology

authors： Sertznig P,Seifert M,Tilgen W,Reichrath J

更新日期：2008-01-01 00:00:00

abstract：:Most people in modern society are exposed daily to fragrance ingredients from one or more sources. Fragrance ingredients are also one of the most frequent causes of contact allergic reactions. The diagnosis is made by patch testing with a mixture of fragrance ingredients, the fragrance mix. This gives a positive patch...

journal_title：American journal of clinical dermatology

authors： Johansen JD

更新日期：2003-01-01 00:00:00