Abstract:
:Tumor necrosis factor (TNF)-α inhibitors are an alternative to oral systemic therapies for psoriasis. Data regarding the safety of TNF-α inhibitors from randomized clinical trials may not fully reflect the effects on the clinic patient population receiving the therapy, but other sources of information are available. We performed a literature review to assess the safety and tolerability of the treatment of moderate-to-severe plaque psoriasis with TNF-α inhibitors. A literature search was conducted using PubMed for articles dating from January 2000 to October 2013. Randomized controlled, cohort, open-label, and observational studies were included, as well as case reports and letters to the editor. Articles found on PubMed describing the safety of anti-TNF-α therapy in psoriasis patients were included, while studies highlighting interleukin (IL)-12 and IL-23 inhibitors were excluded, as were non-English articles. In total, 58 articles were included in the review. TNF-α inhibitors exhibit both efficacy and tolerability in patients with moderate-to-severe plaque psoriasis. Adverse effects associated with these medications are not common and can be minimized with routine clinical monitoring and patient education. While the risk of severe adverse events is low, the lack of very large, long-term, randomized safety trials limits the ability to fully define the safety of these agents. TNF-α inhibitors have a good efficacy/safety ratio for use in patients with moderate-to-severe psoriasis. Serious adverse effects are not common, and common injection-site reactions are usually manageable. The benefits of TNF-α inhibitors outweigh the risks for moderate-to-severe psoriasis; however, there are potential adverse effects and the patient populations at highest risk include the elderly and those with a history of malignancy.
journal_name
Am J Clin Dermatoljournal_title
American journal of clinical dermatologyauthors
Semble AL,Davis SA,Feldman SRdoi
10.1007/s40257-013-0053-5subject
Has Abstractpub_date
2014-02-01 00:00:00pages
37-43issue
1eissn
1175-0561issn
1179-1888journal_volume
15pub_type
杂志文章,评审abstract::Solar, and particularly UV, radiation causes molecular and cellular damage with resultant histopathologic and clinical degenerative changes, leading in turn to photosensitivity, photo-aging, and skin cancer. While our bodies have some natural UV defenses, additional protection from the sun is essential, including sun ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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abstract::Skin disorders are the most common adverse reactions attributed to drugs. Any skin disorder can be imitated, induced or aggravated by drugs. To help you keep up-to-date with the very latest skin reactions occurring with both new and established drugs, this section of the journal brings you information selected from th...
journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,meta分析,评审
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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