Abstract:
:We report a 47-year-old man with Wilson disease who developed bullous lesions on the trunk and extremities after 20 years of penicillamine treatment. The histologic and immunofluorescence findings were diagnostic of bullous pemphigoid. When penicillamine was replaced by zinc sulfate, the patient's bullous skin lesions improved rapidly. However, after 2 months of zinc sulfate treatment, the patient's skin condition remained improved but his neurologic disease became worse and penicillamine was reinstituted. Bullous lesions recurred within 1 week and the diagnosis of penicillamine-induced bullous pemphigoid was confirmed. This is the first report of penicillamine-induced bullous pemphigoid in a patient with Wilson disease.
journal_name
Am J Clin Dermatoljournal_title
American journal of clinical dermatologyauthors
Popadic S,Skiljevic D,Medenica Ldoi
10.2165/0128071-200910010-00006subject
Has Abstractpub_date
2009-01-01 00:00:00pages
36-8issue
1eissn
1175-0561issn
1179-1888pii
1016journal_volume
10pub_type
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