Abstract：
:Subcutaneous adalimumab (Humira®) is a tumour necrosis factor-α blocker that is the only approved agent for the treatment of moderate to severe hidradenitis suppurativa (HS) in several countries worldwide. This article reviews the clinical efficacy and safety of subcutaneous adalimumab in patients with moderate to severe HS. In clinical trials (PIONEER I and II), a greater proportion of adalimumab than placebo recipients reached HS clinical response (HiSCR) at week 12. The main secondary endpoints, such as the proportion of patients with an abscess and inflammatory nodule count of ≤2 at week 12, were significantly greater with adalimumab than with placebo in PIONEER II, but not in PIONEER I. In addition, adalimumab showed the potential to reduce the high health-related quality of life burden of HS and increase patient satisfaction. HiSCR rates were generally maintained in the longer term, and the safety profile of adalimumab in patients with moderate to severe HS was consistent with the known safety profile of the drug for other indications, with no new emerging safety signals. Adalimumab is an effective and generally well tolerated treatment for patients with moderate to severe HS, and is the first agent approved for this difficult-to-treat disease.
journal_name
Am J Clin Dermatoljournal_title
American journal of clinical dermatologyauthors
Kim ES,Garnock-Jones KP,Keam SJdoi
10.1007/s40257-016-0220-6subject
Has Abstractpub_date
2016-10-01 00:00:00pages
545-552issue
5eissn
1175-0561issn
1179-1888pii
10.1007/s40257-016-0220-6journal_volume
17pub_type
杂志文章,评审abstract：:In monosymptomatic hypochondriacal psychosis (MHP), such as delusional infestation (DI), the patient has a fixed, false, encapsulated belief associated with tactile hallucinations (TH), most commonly formication, which is defined as cutaneous sensations of crawling, stinging, biting, etc., without evidence of infestat...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-016-0219-z
更新日期：2016-12-01 00:00:00
abstract：:Most people in modern society are exposed daily to fragrance ingredients from one or more sources. Fragrance ingredients are also one of the most frequent causes of contact allergic reactions. The diagnosis is made by patch testing with a mixture of fragrance ingredients, the fragrance mix. This gives a positive patch...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200304110-00006
更新日期：2003-01-01 00:00:00
abstract：:Aggressive digital papillary adenocarcinoma (ADPAC) is a rare cutaneous malignant tumor. We report on a 42-year-old man presenting with a nontender firm nodule on his right thumb that had been present for 3 years. The lesion clinically resembled an acquired digital fibrokeratoma, but was found to be an ADPAC after pat...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.2165/00128071-200708040-00007
更新日期：2007-01-01 00:00:00
abstract：:For nearly 50 years, thalidomide has struggled between success and controversy. After causing an epidemic of phocomelia and other birth defects during the 1960s, affecting thousands of neonates, thalidomide was used as a sedative in selective disorders including leprosy. The potent anti-inflammatory properties of thal...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200304060-00002
更新日期：2003-01-01 00:00:00
abstract：:Epidermolysis bullosa (EB) represents a group of inherited blistering skin diseases, some forms of which are associated with considerable morbidity and increased mortality. Notably, in recessive dystrophic EB there can be extensive muco-cutaneous fragility and disease complications such as scars, contractures, anemia,...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-013-0059-z
更新日期：2014-02-01 00:00:00
abstract：:We provide a guide for dermatologists to follow if they encounter patients with a rash and clinical history suspicious of Zika virus infection, including diagnostic testing and management options. We also provide an illustrative case report of a patient from Brazil who was diagnosed with Zika virus infection after pre...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-016-0243-z
更新日期：2017-04-01 00:00:00
abstract：:In women, acne can be successfully treated with oral contraceptives. This article focuses on the results of clinical studies on the treatment of acne with oral contraceptives. From the literature, 12 such studies could be traced over the last 10 years. Most of the studies were multicenter, randomized, and double blind...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200405060-00008
更新日期：2004-01-01 00:00:00
abstract：:Uncommon types of cutaneous cancers are mainly cited in the literature as case reports and their etiology, pathogenesis and prognosis have to be surmised because of their rarity. Within this group exist the rare and also the unusual, for instance a relatively common carcinoma arising in a strange circumstance. Initial...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200203020-00002
更新日期：2002-01-01 00:00:00
abstract：:After a marked decline in the number of syphilis cases in the context of AIDS prevention campaigns, a significant increase has been observed in states of the former Soviet Union since 1994. In recent years, outbreaks have also been reported in the US, Canada, and several European countries. The current epidemic in the...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200607050-00003
更新日期：2006-01-01 00:00:00
abstract：:There is a high unmet clinical need for new and better treatments in acne vulgaris. Propionibacterium acnes has a strong proinflammatory activity and targets molecules involved in the innate cutaneous immunity, keratinocytes and sebaceous glands of the pilosebaceous follicle. The role of P. acnes in acne confers legit...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-013-0042-8
更新日期：2013-12-01 00:00:00
abstract：:As psoriasis and psoriatic arthritis are chronic in nature, ideal treatment should have sustained efficacy, with minimal short- and long-term toxicities to allow lifelong treatment. Traditional therapies used for psoriatic arthritis or psoriasis, including phototherapies and systemic agents, do not satisfy these crite...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200506010-00006
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:The relationship between psoriasis and vitiligo has not been previously confirmed, and we therefore aimed to investigate this association. METHODS:We conducted a search of the MEDLINE and EMBASE electronic databases on 22 January 2018 for case-control, cross-sectional, and cohort studies examining the assoc...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,meta分析
doi：10.1007/s40257-018-0394-1
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Atopic dermatitis (AD) is an allergic disorder caused by both immunological dysregulation and epidermal barrier defect. Several studies have investigated the association between AD and mental health disorders. Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental conditions characte...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-015-0145-5
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Confluent and reticulate papillomatosis of Gougerot and Carteaud (CRP) is a rare dermatological condition, which has not been reported widely in Asian populations. AIM:To characterize the clinicopathological and diagnostic features of CRP in a South-East Asian population. METHODS:The medical records of 29 ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.1007/s40257-014-0110-8
更新日期：2015-04-01 00:00:00
abstract：:Lichen planus is a relatively common disorder of the stratified squamous epithelia. Most dental and medical practitioners see patients with lichen planus, but not all are recognized as having the disease. Patients with lichen planus may have concomitant involvement of the disease in multiple sites. Oral lichen planus ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200001050-00004
更新日期：2000-09-01 00:00:00
abstract：BACKGROUND:Methotrexate (MTX) is an effective treatment for psoriasis but its use is limited by its toxicity. Folate supplementation can be used to reduce the adverse effects of MTX, though this may impact efficacy. The frequency of folic acid supplementation is not well characterized. PURPOSE:The objective of this st...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-013-0017-9
更新日期：2013-06-01 00:00:00
abstract：:Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that may be caused by an adverse drug reaction. We discuss the clinical presentation and outcomes of 52 cases of drug-induced PG reported to date in the literature. We conducted our literature search for case reports of drug-induced PG using keywords on PubMe...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-017-0308-7
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:5% topical minoxidil solution has been widely used to stimulate new hair growth and help stop hair loss in men with androgenetic alopecia (AGA). However, it is not convenient for patients to continue applying the solution twice daily on a regular basis. Tretinoin is known to increase the percutaneous absorpt...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,随机对照试验
doi：10.2165/00128071-200708050-00003
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:Scalp psoriasis is commonly the initial presentation of psoriasis, and almost 80 % of patients with psoriasis will eventually experience it. OBJECTIVE:Although several systematic reviews and guidelines exist, an up-to-date evidence-based review including more recent progress on the use of biologics and new ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-016-0222-4
更新日期：2017-02-01 00:00:00
abstract：:The treatment of cutaneous T cell lymphoma (CTCL), which includes mycosis fungoides and Sezary syndrome, has been in a state of continual change over recent decades, as new therapies are constantly emerging in the search for more effective treatments for the disease. However, prognosis and survival of patients with CT...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200203030-00006
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:The management of acne in adult females is problematic, with many having a history of treatment failure and some having a predisposition to androgen excess. Alternatives to oral antibiotics and combined oral contraceptives (COCs) are required. OBJECTIVE:Our aim was to conduct a hybrid systematic review of t...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-016-0245-x
更新日期：2017-04-01 00:00:00
abstract：:The etiologies of a variety of skin conditions associated with diabetes have not been fully explained. One possible etiological factor is diabetic microangiopathy, which is known to affect the eyes and kidneys in patients with diabetes. There are many mechanisms by which diabetes may cause microangiopathy. These inclu...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200506040-00003
更新日期：2005-01-01 00:00:00
abstract：:This review summarizes results from major recent trials regarding novel therapeutic agents in melanoma. The topics discussed include targeted therapy with BRAF (V-RAF murine sarcoma viral oncogene homolog B) inhibitors (vemurafenib and dabrafenib), MEK (mitogen-activated protein kinase kinase) inhibitors (trametinib),...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-014-0083-7
更新日期：2014-08-01 00:00:00
abstract：:Skin disorders are the most common adverse reactions attributed to drugs. Any skin disorder can be imitated, induced or aggravated by drugs. To help you keep up-to-date with the very latest skin reactions occurring with both new and established drugs, this section of the journal brings you information selected from th...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200304070-00007
更新日期：2003-01-01 00:00:00
abstract：:Erythema annulare centrifugum is a reactive erythema of various possible etiologies including, although less often, an associated cancer. Cancer-related erythema annulare centrifugum is most commonly associated with lymphoproliferative malignancies, specifically lymphoma and leukemia. Malignancy-associated erythema an...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/11596580-000000000-00000
更新日期：2012-08-01 00:00:00
abstract：:Pantothenic acid is essential to normal epithelial function. It is a component of coenzyme A, which serves as a cofactor for a variety of enzyme-catalyzed reactions that are important in the metabolism of carbohydrates, fatty acids, proteins, gluconeogenesis, sterols, steroid hormones, and porphyrins. The topical use ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200203060-00005
更新日期：2002-01-01 00:00:00
abstract：:Solar, and particularly UV, radiation causes molecular and cellular damage with resultant histopathologic and clinical degenerative changes, leading in turn to photosensitivity, photo-aging, and skin cancer. While our bodies have some natural UV defenses, additional protection from the sun is essential, including sun ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/0128071-200910001-00004
更新日期：2009-01-01 00:00:00
abstract：:We report a 47-year-old man with Wilson disease who developed bullous lesions on the trunk and extremities after 20 years of penicillamine treatment. The histologic and immunofluorescence findings were diagnostic of bullous pemphigoid. When penicillamine was replaced by zinc sulfate, the patient's bullous skin lesions...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.2165/0128071-200910010-00006
更新日期：2009-01-01 00:00:00
abstract：:Tildrakizumab (tildrakizumab-asmn in the USA) [Ilumetri®; Ilumya™] is a humanized monoclonal antibody (mAb) that selectively targets the p19 subunit of interleukin (IL)-23, thereby inhibiting the IL-23/IL-17 axis, the signalling pathway primarily implicated in the immunopathogenesis of psoriasis. Administered subcutan...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-019-00435-9
更新日期：2019-04-01 00:00:00
abstract：:Of all the psychotropic medications currently available, the mood-stabilizing agents have the highest incidence of severe and life-threatening adverse cutaneous drug reactions (ACDRs). An exanthematous eruption in a patient treated with a mood-stabilizing agent should be viewed as possibly being the initial symptom of...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200304010-00003
更新日期：2003-01-01 00:00:00
