Abstract：
:A 46-year-old man developed Stevens-Johnson syndrome and toxic epidermal necrolysis overlap, with severe localized denudation of the skin on the head and neck, following radiotherapy and oral temozolomide therapy for cranial glioblastoma multiforme. He also had a primary malignant fibrous histiocytoma of the thigh that was amputated 5 years earlier. A rash developed after 7 days of radio- and chemotherapy. It was an extensive maculopapular rash that started over the temporal area of the head and rapidly spread, sparing only the distal limbs. Radiotherapy and temozolomide were stopped on the tenth day but the rash rapidly progressed for the next 4-6 days. Following this, the spread halted and complete recovery was observed within the next 2 weeks. The peculiarity of the presentation in this case was that the brunt of the disease with severe skin denudation was localized to the surrounding areas of cranial radiotherapy. The patient was also receiving oral phenytoin, diclofenac, and parenteral dexamethasone before chemotherapy was started. These medications were continued, even after development of the skin rash, until well after full recovery from the skin lesions. After critical evaluation of disease onset, progression, and recovery, and their relationship to the introduction and withdrawal of different medicines, it appeared that either temozolomide alone or in combination with radiotherapy most probably triggered the condition.
journal_name
Am J Clin Dermatoljournal_title
American journal of clinical dermatologyauthors
Sarma Ndoi
10.2165/00128071-200910040-00007subject
Has Abstractpub_date
2009-01-01 00:00:00pages
264-7issue
4eissn
1175-0561issn
1179-1888pii
7journal_volume
10pub_type
杂志文章abstract：:Topical retapamulin (Altabax, Altargo) is the first pleuromutilin antibacterial approved for the treatment of uncomplicated superficial skin infections caused by Staphylococcus aureus (excluding methicillin-resistant S. aureus [MRSA]) and Streptococcus pyogenes in patients aged > or = 9 months. In the EU, retapamulin ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.2165/0128071-200809060-00010
更新日期：2008-01-01 00:00:00
abstract：:We report a 47-year-old man with Wilson disease who developed bullous lesions on the trunk and extremities after 20 years of penicillamine treatment. The histologic and immunofluorescence findings were diagnostic of bullous pemphigoid. When penicillamine was replaced by zinc sulfate, the patient's bullous skin lesions...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.2165/0128071-200910010-00006
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:5% topical minoxidil solution has been widely used to stimulate new hair growth and help stop hair loss in men with androgenetic alopecia (AGA). However, it is not convenient for patients to continue applying the solution twice daily on a regular basis. Tretinoin is known to increase the percutaneous absorpt...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,随机对照试验
doi：10.2165/00128071-200708050-00003
更新日期：2007-01-01 00:00:00
abstract：:Immunotherapy has revolutionized the treatment of melanoma. Targeting of the immune checkpoints cytotoxic T-lymphocyte-associated protein 4 and programmed cell death protein 1 has led to improved survival in a subset of patients. Unfortunately, the use of immune checkpoint inhibitors is associated with significant sid...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-019-00475-1
更新日期：2020-02-01 00:00:00
abstract：:Solar, and particularly UV, radiation causes molecular and cellular damage with resultant histopathologic and clinical degenerative changes, leading in turn to photosensitivity, photo-aging, and skin cancer. While our bodies have some natural UV defenses, additional protection from the sun is essential, including sun ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/0128071-200910001-00004
更新日期：2009-01-01 00:00:00
abstract：:The incidence of basal cell carcinoma is rapidly increasing and a number of treatment modalities are available. Treatment of basal cell carcinoma includes both surgical and nonsurgical approaches, some of which are traditional, and others experimental. The treatment modality utilized is dependent on both the tumor typ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200203040-00003
更新日期：2002-01-01 00:00:00
abstract：:Lichen planus is a relatively common disorder of the stratified squamous epithelia. Most dental and medical practitioners see patients with lichen planus, but not all are recognized as having the disease. Patients with lichen planus may have concomitant involvement of the disease in multiple sites. Oral lichen planus ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200001050-00004
更新日期：2000-09-01 00:00:00
abstract：:Skin disorders are the most common adverse reactions attributed to drugs. Any skin disorder can be imitated, induced or aggravated by drugs. To help you keep up-to-date with the very latest skin reactions occurring with both new and established drugs, this section of the journal brings you information selected from th...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200304070-00007
更新日期：2003-01-01 00:00:00
abstract：:Recent advances in our understanding of the pathophysiology of atopic dermatitis (AD) have revealed that skin microbiome dysbiosis plays an important role in the disease. In this review, we describe how changes in the structure and function of the microbiome are involved in the pathogenesis of AD. We highlight recent ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-020-00538-8
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:Based on the results of numerous preclinical and clinical studies, sertaconazole can be considered a safe and effective drug for the treatment of fungal skin infections. OBJECTIVE:The objective of the study was to compare the efficacy of a solution containing 2% sertaconazole with the well established 2% se...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.2165/00128071-200708060-00007
更新日期：2007-01-01 00:00:00
abstract：:Acne vulgaris is one of the most common inflammatory dermatoses and is seen in both the hospital setting and in general practice. Multiple factors are involved in the pathophysiology of acne, including: an alteration in the pattern of keratinization within the pilosebaceous follicles resulting in comedone formation; a...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200102030-00002
更新日期：2001-01-01 00:00:00
abstract：:Aging of the skin is associated with skin thinning, atrophy, dryness, wrinkling, and delayed wound healing. These undesirable aging effects are exacerbated by declining estrogen levels in postmenopausal women. With the rise in interest in long-term postmenopausal skin management, studies on the restorative benefits th...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/11589180-000000000-00000
更新日期：2011-10-01 00:00:00
abstract：:Uncommon types of cutaneous cancers are mainly cited in the literature as case reports and their etiology, pathogenesis and prognosis have to be surmised because of their rarity. Within this group exist the rare and also the unusual, for instance a relatively common carcinoma arising in a strange circumstance. Initial...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200203020-00002
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:The management of acne in adult females is problematic, with many having a history of treatment failure and some having a predisposition to androgen excess. Alternatives to oral antibiotics and combined oral contraceptives (COCs) are required. OBJECTIVE:Our aim was to conduct a hybrid systematic review of t...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-016-0245-x
更新日期：2017-04-01 00:00:00
abstract：:The dermis normally directs all phases of skin wound healing following tissue trauma or disease. However, in chronic wounds, the dermal matrix is insufficient to stimulate healing and assistance by external factors is needed for wound closure. Although the concept of the extracellular matrix directing wound healing is...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200708020-00001
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:Efforts have been recently made to investigate simple, objective, accurate, and reproducible methods of clinical/noninvasive assessment of nonsegmental vitiligo. However, studies have mostly considered quantitative or semiquantitative parameters, almost neglecting the purely qualitative appearance of vitilig...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.1007/s40257-012-0001-9
更新日期：2013-02-01 00:00:00
abstract：:Airbags are restraining safety devices, but their activation may sometimes induce injuries during road accidents. Rapid deceleration due to an impact causes the ignition of a sodium azide cartridge, which releases nitrogen gas to inflate the nylon rubber bag. Numerous high-temperature gases, sodium hydroxide, carbon d...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200405050-00002
更新日期：2004-01-01 00:00:00
abstract：:At least 20 clinically relevant factors affect percutaneous absorption of drugs and chemicals: relevant physico-chemical properties, vehicle/formulation, drug exposure conditions (dose, duration, surface area, exposure frequency), skin appendages (hair follicles, glands) as sub-anatomical pathways, skin application si...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-019-00480-4
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:A few studies in psoriasis vulgaris patients have reported changes suggesting red blood cell (RBC) damage is linked to neutrophil activation, oxidative stress, and psoriasis worsening. OBJECTIVE:The aim of this study was to evaluate erythroid disturbances in Portuguese psoriasis vulgaris patients, before, d...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.2165/11592110-000000000-00000
更新日期：2012-02-01 00:00:00
abstract：:The family of toll-like receptors (TLRs) plays a central role in the cutaneous immune defense system. To date, different TLRs have been found on several major cell populations of the skin, such as keratinocytes, fibroblasts, antigen-presenting cells, and melanocytes. Activation of TLRs leads, via different intracellul...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/11311110-000000000-00000
更新日期：2010-01-01 00:00:00
abstract：:Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous tumor with a predilection for the head and neck of elderly Caucasian patients. Although much less common than melanoma, MCC has higher rates of sentinel lymph node involvement, local and regional recurrences, and mortality. The majority of MCC cases have b...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-015-0163-3
更新日期：2016-02-01 00:00:00
abstract：:Birt-Hogg-Dubé syndrome (BHD) is an autosomal dominant genodermatosis with malignant potential characterized by cutaneous and extracutaneous stigmata. Aberrations in the folliculin (FLCN) gene, which is located on chromosome 17, have been discovered in individuals with this condition. Over 150 unique mutations have be...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-017-0307-8
更新日期：2018-02-01 00:00:00
abstract：:Seborrheic dermatitis (SD) is characterized by erythematous pruritic patches and plaques with greasy scale that occur in sebaceous areas. It is common, affecting up to 3% of the population. Past treatments have relied on a wide variety of anti-inflammatory and antifungal agents, but corticosteroids have limited use be...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200910020-00003
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Evidence regarding what comprises effective education for acne vulgaris patients is lacking. Internet-based education may improve patient knowledge of this condition. OBJECTIVES:Our objective was to compare the effectiveness of standard web-based education and an automated counseling website in improving ac...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s40257-014-0104-6
更新日期：2015-02-01 00:00:00
abstract：:Topical pimecrolimus 1% cream (Elidel) [hereafter referred to as topical pimecrolimus] is a nonsteroidal alternative in the treatment of pediatric atopic dermatitis. In vehicle-controlled, short-term, continuous-use trials in pediatric patients with mild to moderate atopic dermatitis, topical pimecrolimus was effectiv...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.2165/11204640-000000000-00000
更新日期：2010-01-01 00:00:00
abstract：:Topical therapy is one of the foundations of dermatology. The vehicles used to deliver topical therapy have considerable impact on efficacy. The vehicle can have direct effects on disease; it can impact the delivery of the active drug, and its characteristics affect patient compliance. While the physical chemistry of ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.2165/00128071-200304040-00001
更新日期：2003-01-01 00:00:00
abstract：:Vitamin B12, also known as cobalamin, is a water-soluble vitamin that is important in the hematological and nervous systems, and it has a complex relationship with the skin. Altered cobalamin levels can lead to dermatological manifestations, which may indicate a deficiency or excess of this vitamin. The biochemistry a...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-014-0107-3
更新日期：2015-02-01 00:00:00
abstract：:Tildrakizumab (tildrakizumab-asmn in the USA) [Ilumetri®; Ilumya™] is a humanized monoclonal antibody (mAb) that selectively targets the p19 subunit of interleukin (IL)-23, thereby inhibiting the IL-23/IL-17 axis, the signalling pathway primarily implicated in the immunopathogenesis of psoriasis. Administered subcutan...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-019-00435-9
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Cutaneous lichen planus (CLP) is an inflammatory dermatosis. Its chronic relapsing course and frequently spontaneous regression hamper the assessment of treatment effectiveness. OBJECTIVE:To evaluate the efficacy of available treatment modalities for CLP. DATA SOURCES:PubMed, Cochrane Central Register of C...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s40257-015-0160-6
更新日期：2016-02-01 00:00:00
abstract：:Coccidioidomycosis is an endemic mycosis of the southern United States, Northern Mexico, and South America. Primary cutaneous coccidioidomycosis, despite being a very rare clinical presentation, has shown an increasing incidence. An extensive literature search for cutaneous coccidioidomycosis cases was performed using...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-020-00525-z
更新日期：2020-10-01 00:00:00
