Abstract:
:Non-infectious granulomatous diseases of the skin are a broad group of distinct reactive inflammatory conditions that share important similarities. As a group, they are relatively difficult to diagnose and distinguish both clinically as well as histologically. Many of these disorders have significant associations with systemic diseases that impact the patient's overall prognosis. In this update, we offer a discussion of emerging concepts and controversies in this field, as presented through evidence-based answers to seven important clinical questions regarding palisading and epithelioid granulomata. These questions offer an opportunity to review ten non-infectious granulomatous conditions that have implications for systemic disease: granuloma annulare, annular elastolytic giant cell granuloma, necrobiosis lipoidica, methotrexate-induced accelerated rheumatoid nodulosis, necrobiotic xanthogranuloma, interstitial granulomatous dermatitis, interstitial granulomatous drug reaction, palisaded neutrophilic granulomatous dermatitis, sarcoidosis, and metastatic Crohn disease. Recent clinical, epidemiologic, and laboratory studies have shed some light on these diseases, the association of these conditions with systemic disorders, and their overall prognoses.
journal_name
Am J Clin Dermatoljournal_title
American journal of clinical dermatologyauthors
Hawryluk EB,Izikson L,English JC 3rddoi
10.2165/11530080-000000000-00000subject
Has Abstractpub_date
2010-01-01 00:00:00pages
171-81issue
3eissn
1175-0561issn
1179-1888journal_volume
11pub_type
杂志文章,评审abstract::Erythema nodosum (EN) is the most common form of panniculitis. It is characterized by erythematous, raised, tender nodules that usually occur bilaterally on the extensor surfaces of the lower extremities. EN is associated with many underlying conditions including infection, sarcoidosis, malignancy, and pregnancy. Its ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-013-0024-x
更新日期:2013-06-01 00:00:00
abstract::Chronic itch is a common skin manifestation in many connective tissue diseases. However, the cause of chronic itch in these diseases is still not fully understood. The complex, and in some cases incomplete understanding of, pathogenesis in each condition makes it difficult to target specific mediators of chronic itch....
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-016-0201-9
更新日期:2016-10-01 00:00:00
abstract::Pantothenic acid is essential to normal epithelial function. It is a component of coenzyme A, which serves as a cofactor for a variety of enzyme-catalyzed reactions that are important in the metabolism of carbohydrates, fatty acids, proteins, gluconeogenesis, sterols, steroid hormones, and porphyrins. The topical use ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200203060-00005
更新日期:2002-01-01 00:00:00
abstract::Acne vulgaris is one of the most common inflammatory dermatoses and is seen in both the hospital setting and in general practice. Multiple factors are involved in the pathophysiology of acne, including: an alteration in the pattern of keratinization within the pilosebaceous follicles resulting in comedone formation; a...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200102030-00002
更新日期:2001-01-01 00:00:00
abstract::Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that may be caused by an adverse drug reaction. We discuss the clinical presentation and outcomes of 52 cases of drug-induced PG reported to date in the literature. We conducted our literature search for case reports of drug-induced PG using keywords on PubMe...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-017-0308-7
更新日期:2018-02-01 00:00:00
abstract::Vitamin B12, also known as cobalamin, is a water-soluble vitamin that is important in the hematological and nervous systems, and it has a complex relationship with the skin. Altered cobalamin levels can lead to dermatological manifestations, which may indicate a deficiency or excess of this vitamin. The biochemistry a...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-014-0107-3
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Evidence regarding what comprises effective education for acne vulgaris patients is lacking. Internet-based education may improve patient knowledge of this condition. OBJECTIVES:Our objective was to compare the effectiveness of standard web-based education and an automated counseling website in improving ac...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s40257-014-0104-6
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Confluent and reticulate papillomatosis of Gougerot and Carteaud (CRP) is a rare dermatological condition, which has not been reported widely in Asian populations. AIM:To characterize the clinicopathological and diagnostic features of CRP in a South-East Asian population. METHODS:The medical records of 29 ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.1007/s40257-014-0110-8
更新日期:2015-04-01 00:00:00
abstract::Vitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproductive diseases, infections, and autoimmune and dermatological disorders. The two main sources of vitamin D are sun exposure and oral intake, including vitamin D supplementation and dietary intake. Mult...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-017-0323-8
更新日期:2018-04-01 00:00:00
abstract::We report a 47-year-old man with Wilson disease who developed bullous lesions on the trunk and extremities after 20 years of penicillamine treatment. The histologic and immunofluorescence findings were diagnostic of bullous pemphigoid. When penicillamine was replaced by zinc sulfate, the patient's bullous skin lesions...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/0128071-200910010-00006
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:A few studies in psoriasis vulgaris patients have reported changes suggesting red blood cell (RBC) damage is linked to neutrophil activation, oxidative stress, and psoriasis worsening. OBJECTIVE:The aim of this study was to evaluate erythroid disturbances in Portuguese psoriasis vulgaris patients, before, d...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/11592110-000000000-00000
更新日期:2012-02-01 00:00:00
abstract::Skin disorders are the most common adverse reactions attributed to drugs. Any skin disorder can be imitated, induced or aggravated by drugs. To help you keep up-to-date with the very latest skin reactions occurring with both new and established drugs, this section of the journal brings you information selected from th...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200304070-00007
更新日期:2003-01-01 00:00:00
abstract::Erythema annulare centrifugum is a reactive erythema of various possible etiologies including, although less often, an associated cancer. Cancer-related erythema annulare centrifugum is most commonly associated with lymphoproliferative malignancies, specifically lymphoma and leukemia. Malignancy-associated erythema an...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/11596580-000000000-00000
更新日期:2012-08-01 00:00:00
abstract::A recent study demonstrated an association between psoriasis and dilated cardiomyopathy. Tumour necrosis factor alpha (TNFalpha) may be involved in the pathogenesis of dilated cardiomyopathy and therefore, anti-TNFalpha agents may play a role in the treatment of dilated cardiomyopathy. The case of a 51-year-old woman ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/1153425-S0-000000000-00000
更新日期:2010-01-01 00:00:00
abstract::Coccidioidomycosis is an endemic mycosis of the southern United States, Northern Mexico, and South America. Primary cutaneous coccidioidomycosis, despite being a very rare clinical presentation, has shown an increasing incidence. An extensive literature search for cutaneous coccidioidomycosis cases was performed using...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-020-00525-z
更新日期:2020-10-01 00:00:00
abstract::Tumor necrosis factor (TNF)-α inhibitors are an alternative to oral systemic therapies for psoriasis. Data regarding the safety of TNF-α inhibitors from randomized clinical trials may not fully reflect the effects on the clinic patient population receiving the therapy, but other sources of information are available. W...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-013-0053-5
更新日期:2014-02-01 00:00:00
abstract::Topical retapamulin (Altabax, Altargo) is the first pleuromutilin antibacterial approved for the treatment of uncomplicated superficial skin infections caused by Staphylococcus aureus (excluding methicillin-resistant S. aureus [MRSA]) and Streptococcus pyogenes in patients aged > or = 9 months. In the EU, retapamulin ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/0128071-200809060-00010
更新日期:2008-01-01 00:00:00
abstract::Microdermabrasion is a simple, safe, office cosmetic procedure in which aluminum oxide crystals or other abrasive substances are blown onto the face, then vacuumed off, using a single handpiece. This procedure has rapidly become widely utilized for a variety of cosmetic objectives, including the improvement of photoag...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200506020-00003
更新日期:2005-01-01 00:00:00
abstract:SIGNIFICANCE:Psoriasis, a common immune-mediated disease, affects approximately 2% of the population worldwide. Sudden sensorineural hearing loss (SSNHL) might be a manifestation of systemic vascular involvement in autoimmune disease. However, to the best of our knowledge, there is no systematic English-language examin...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.1007/s40257-015-0117-9
更新日期:2015-06-01 00:00:00
abstract::In women, acne can be successfully treated with oral contraceptives. This article focuses on the results of clinical studies on the treatment of acne with oral contraceptives. From the literature, 12 such studies could be traced over the last 10 years. Most of the studies were multicenter, randomized, and double blind...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200405060-00008
更新日期:2004-01-01 00:00:00
abstract::Granuloma annulare (GA) is a chronic inflammatory disease of unknown etiology characterized by the development of plaques preferentially localized to the distal extremities. Spontaneous remission and relapses are quite common and the course of GA is not easy to predict. Moreover, most therapeutic regimens have been us...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/11311040-000000000-00000
更新日期:2010-12-01 00:00:00
abstract::Vulvar lichen sclerosus is an important skin disease that is common in women in their 50 s and beyond; however, it can also affect females of any age, including children. If not treated, it has the potential to cause significant and permanent scarring and deformity of the vulvar structure. In addition, if untreated, i...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-018-0364-7
更新日期:2018-10-01 00:00:00
abstract::Eruptive melanocytic nevi (EMN) is a phenomenon characterized by the sudden onset of nevi. Our objective was to compile all published reports of EMN to identify possible precipitating factors and to evaluate the clinical appearance and course. We conducted a systematic bibliographic search and selected 93 articles, re...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-019-00444-8
更新日期:2019-10-01 00:00:00
abstract::A 46-year-old man developed Stevens-Johnson syndrome and toxic epidermal necrolysis overlap, with severe localized denudation of the skin on the head and neck, following radiotherapy and oral temozolomide therapy for cranial glioblastoma multiforme. He also had a primary malignant fibrous histiocytoma of the thigh tha...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/00128071-200910040-00007
更新日期:2009-01-01 00:00:00
abstract::Hyperhidrosis is a common and distressing condition involving increased production of sweat. A variety of treatment modalities are used to try to control or reduce sweating. Sweat is secreted by eccrine glands innervated by cholinergic fibers from the sympathetic nervous system. Primary hyperhidrosis most commonly aff...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200304100-00003
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Videodermatoscopy is a non-invasive technique that allows in vivo skin observation at high magnifications. OBJECTIVE:The goal of this study was to determine if videodermatoscopy enhances diagnostic capability beyond standard clinical observation in three series of patients: one group of patients with overt ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/00128071-200405030-00009
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Botulinum toxin (BTX) is a potent neurotoxin with a long history of therapeutic application in neurological and dermatological conditions, with a strong efficacy and safety profile. OBJECTIVE:Our aim was to assess whether intradermal injection with BTX-B is an effective treatment for hidradenitis suppurativ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.1007/s40257-020-00537-9
更新日期:2020-10-01 00:00:00
abstract::Chronic venous insufficiency (CVI) occurs in a relatively large proportion of the population and is associated with significant morbidity, high cost of healthcare, loss of productivity and reduced quality of life. Lower extremity ulcers related to CVI have been estimated to affect 0.2-1% of the population in developed...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200304080-00007
更新日期:2003-01-01 00:00:00
abstract::Epidermolysis bullosa (EB) represents a group of inherited blistering skin diseases, some forms of which are associated with considerable morbidity and increased mortality. Notably, in recessive dystrophic EB there can be extensive muco-cutaneous fragility and disease complications such as scars, contractures, anemia,...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-013-0059-z
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Scalp psoriasis is commonly the initial presentation of psoriasis, and almost 80 % of patients with psoriasis will eventually experience it. OBJECTIVE:Although several systematic reviews and guidelines exist, an up-to-date evidence-based review including more recent progress on the use of biologics and new ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-016-0222-4
更新日期:2017-02-01 00:00:00