Abstract:
:Chronic venous insufficiency (CVI) occurs in a relatively large proportion of the population and is associated with significant morbidity, high cost of healthcare, loss of productivity and reduced quality of life. Lower extremity ulcers related to CVI have been estimated to affect 0.2-1% of the population in developed countries. The prevalence of venous ulcers in the US is estimated at 500,000-600,000, and increases with age. Estimates of the annual incidence of leg ulcer in the UK and Switzerland are 3.5 and 0.2 per 1000 individuals, respectively. Treatment of venous ulcers can be expensive, leading to a large economic burden on health services in many countries. The annual cost of CVI is estimated to be more than 1 billion US dollars in the US and between pound 400-600 million in the UK. Current treatments for CVI include surgery, sclerotherapy, compressive therapy (conventional therapy) and adjuvant pharmacotherapy. Various pharmacological agents have been used as adjuvant therapy but in many cases there is no definitive evidence of their efficacy. Effective treatment programs for venous leg ulcers could substantially reduce the economic impact of CVI on health services. In controlled studies, micronized purified flavonoid fraction (MPFF) adjuvant therapy has been shown to increase significantly the number of healed venous leg ulcers and to reduce significantly the healing time of ulcers compared with conventional therapy alone, potentially leading to an improvement in patients' quality of life. The treatment of venous leg ulcers with MPFF was also found to reduce overall treatment costs compared with conventional therapy alone. In a retrospective cost-effectiveness analysis based on direct medical costs only, MPFF therapy improved the cost-effectiveness ratio by 45% compared with conventional therapy. If intangible costs, such as loss of quality of life were included, the difference in cost-effectiveness ratios is likely to be even greater in favor of MPFF. Sensitivity analyzes showed that even with a 20% increase in drug price the cost-effectiveness ratio for MPFF therapy was substantially better than that for conventional therapy (1061.8 US dollars vs 1871.9 US dollars per ulcer healed). Hence, the addition of MPFF adjuvant therapy to the treatment of venous leg ulcers would be effective and potentially cost saving.
journal_name
Am J Clin Dermatoljournal_title
American journal of clinical dermatologyauthors
Simka M,Majewski Edoi
10.2165/00128071-200304080-00007subject
Has Abstractpub_date
2003-01-01 00:00:00pages
573-81issue
8eissn
1175-0561issn
1179-1888pii
487journal_volume
4pub_type
杂志文章,评审abstract:BACKGROUND:Psoriasis has been associated with psychiatric disorders such as depression and anxiety, but its relationship with suicidality (including suicide, suicide attempt, and suicidal ideation) is unclear. OBJECTIVE:Our objective was to assess the risk of suicide, suicide attempt, suicidal ideation, and suicidalit...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s40257-017-0281-1
更新日期:2017-10-01 00:00:00
abstract::Our ability to successfully treat patients with moderate to severe psoriasis has improved significantly over the last several years with the development of more targeted therapies. IL-17A, a member of the IL-17 family of interleukins, is involved in regulating the innate and adaptive immune systems and has been identi...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/00128071-200708040-00007
更新日期:2007-01-01 00:00:00
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200001050-00004
更新日期:2000-09-01 00:00:00
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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doi:10.2165/11589180-000000000-00000
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200102040-00004
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200910050-00001
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/11530210-000000000-00000
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,随机对照试验,评审
doi:10.2165/00128071-200607040-00001
更新日期:2006-01-01 00:00:00
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.1007/s40257-015-0117-9
更新日期:2015-06-01 00:00:00
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/0128071-200910010-00006
更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-10-01 00:00:00
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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更新日期:2015-12-01 00:00:00
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200304110-00006
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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doi:10.2165/00128071-200304050-00006
更新日期:2003-01-01 00:00:00
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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更新日期:2000-03-01 00:00:00
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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