Abstract:
BACKGROUND:Dementia is a syndrome that involves the deterioration of several higher mental functions in advanced age, and psoriasis is an autoimmune disease characterized by skin plaque. Epidemiological studies have indicated an association between dementia and psoriasis; however, to date, no studies in Asia have reported this association. OBJECTIVE:This study used a population-based medical dataset to explore the association between previously diagnosed psoriasis and dementia in Taiwan. METHODS:Using the Taiwan Longitudinal Health Insurance Database 2000, we identified 7118 individuals with a diagnosis of dementia; a further 21,354 sex- and aged-matched individuals were randomly extracted as controls. Patients with bullous pemphigoid, which is characterized by inflammatory phenomena similar to that evident in psoriasis, were chosen as a control group. Conditional logistic regression was performed to evaluate the association between dementia and prior psoriasis or bullous pemphigoid among the sampled patients. RESULTS:Of the 28,472 individuals, 2.2, 3.0, and 1.5% of the total, case, and control groups, respectively, had been diagnosed with psoriasis. After adjustments were made for patients' monthly income, region, urbanization level, diabetes, hyperlipidemia, hypertension, and coronary heart disease, the odds ratio (OR) of diagnosed psoriasis for the case group was 1.46 (95% confidence interval [CI] 1.23-1.73; p < 0.001) compared with the control group. The ORs of a previous psoriasis diagnosis with arthritis and without arthritis in the case group were, respectively, 1.95 and 1.44 times (95% CI 1.03-3.89 and 1.21-1.72, respectively) those of the control group after adjustments for socioeconomic variables, diabetes, hyperlipidemia, hypertension, and coronary heart disease. However, no significant differences in prior bullous pemphigoid were observed between the dementia and control groups (0.5% and 0.4%, respectively). CONCLUSIONS:More patients with dementia had prior psoriasis than did patients in the control group. Additional research is required to confirm our results and clarify the relationship.
journal_name
Am J Clin Dermatoljournal_title
American journal of clinical dermatologyauthors
Lin CC,Lin HC,Chiu HWdoi
10.1007/s40257-018-00420-8subject
Has Abstractpub_date
2019-06-01 00:00:00pages
457-463issue
3eissn
1175-0561issn
1179-1888pii
10.1007/s40257-018-00420-8journal_volume
20pub_type
杂志文章abstract::Topical pimecrolimus 1% cream (Elidel) [hereafter referred to as topical pimecrolimus] is a nonsteroidal alternative in the treatment of pediatric atopic dermatitis. In vehicle-controlled, short-term, continuous-use trials in pediatric patients with mild to moderate atopic dermatitis, topical pimecrolimus was effectiv...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/11204640-000000000-00000
更新日期:2010-01-01 00:00:00
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journal_title:American journal of clinical dermatology
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doi:10.1007/s40257-015-0117-9
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abstract::Intravenous immunoglobulin (IVIg) has been proposed as a treatment for toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS). A comprehensive search of the literature was conducted to examine the efficacy and safety of IVIg in TEN and SJS patients. Seventeen relevant articles (14 TEN, 3 SJS) were identif...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200607060-00004
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200102060-00002
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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doi:10.2165/00128071-200607040-00001
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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journal_title:American journal of clinical dermatology
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更新日期:2004-01-01 00:00:00
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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更新日期:2017-12-01 00:00:00