Abstract：
:Radiation-recall dermatitis is the occurrence, with subsequent administration of cytotoxic chemotherapy, of an acute inflammatory toxicity in a previously quiescent radiation field. It may occur from days to weeks, and sometimes years, after the radiation therapy. The precise mechanism is unknown. One hypothesis suggests that the initial radiation therapy leads to a depletion of tissue stem cells within the irradiated field and that subsequent cytotoxic chemotherapy exposure causes a 'remembered' reaction among the remaining surviving cells. An alternative proposition suggests that radiation induces heritable mutations within surviving cells, which then produce a subgroup of defective stem cells that are unable to tolerate the second insult of chemotherapy. Recently, ataxia telangiectasia gene mutation and protein kinase deficiency have been associated with patients who have increased susceptibility to severe radiation-induced skin toxicity. Most of the lesions will heal with supportive treatment. Although some reports have noted that radiation-recall dermatitis recurred with subsequent continued administration of the same chemotherapeutic agent, such experience is not universal. At present, a decision as to whether the same chemotherapeutic agent can be continued will usually be determined by the severity of the initial reaction, the chemoresponsiveness of the tumor to this particular agent, the individual patient's wishes, and a clinical judgment that takes into account the availability of alternative therapy.
journal_name
Am J Clin Dermatoljournal_title
American journal of clinical dermatologyauthors
Yeo W,Johnson PJdoi
10.2165/00128071-200001020-00006subject
Has Abstractpub_date
2000-03-01 00:00:00pages
113-6issue
2eissn
1175-0561issn
1179-1888journal_volume
1pub_type
杂志文章,评审abstract：:Skin disorders are the most common adverse reactions attributed to drugs. Any skin disorder can be imitated, induced or aggravated by drugs. To help you keep up-to-date with the very latest skin reactions occurring with both new and established drugs, this section of the journal brings you information selected from th...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200203070-00009
更新日期：2002-01-01 00:00:00
abstract：:Ultrapotent topical corticosteroids are the mainstay of psoriasis treatment, used either alone or in combination with a topical vitamin D analog. Traditionally used in an ointment vehicle for psoriasis, clobetasol propionate 0.05% is also available in spray, foam, lotion, and shampoo formulations, which may provide fo...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/11311020-000000000-00000
更新日期：2009-01-01 00:00:00
abstract：:Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily that regulate lipid, glucose, and amino acid metabolism. More recently, PPARs and corresponding ligands have been shown in skin and other organs to regulate important cellular functions, including cell proliferation and...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200809010-00002
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Methotrexate (MTX) is an effective treatment for psoriasis but its use is limited by its toxicity. Folate supplementation can be used to reduce the adverse effects of MTX, though this may impact efficacy. The frequency of folic acid supplementation is not well characterized. PURPOSE:The objective of this st...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-013-0017-9
更新日期：2013-06-01 00:00:00
abstract：:The connection between the brain and the skin is more than a physiologic fact. Skin conditions can impose great effects on every field in the patients' lives. Reciprocally, skin diseases can be evoked by psychological problems. A psychodermatology clinic is the format that enables dermatology patients to receive a com...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.2165/11630950-000000000-00000
更新日期：2012-04-01 00:00:00
abstract：:Occupational contact dermatitis (OCD) represents 90 to 95% of all occupational dermatoses. The incidence rate of OCD is estimated to be around 0.5 to 1.9 cases per full-time worker per year. However, epidemiologic data are lacking and incidence is probably underestimated, especially in the US. Over the past 20 years, ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200102060-00002
更新日期：2001-01-01 00:00:00
abstract：:We provide a guide for dermatologists to follow if they encounter patients with a rash and clinical history suspicious of Zika virus infection, including diagnostic testing and management options. We also provide an illustrative case report of a patient from Brazil who was diagnosed with Zika virus infection after pre...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-016-0243-z
更新日期：2017-04-01 00:00:00
abstract：:Childhood-onset psoriasis affects approximately one-third of the psoriatic population. Among many potential treatments of childhood psoriasis, biological agents are emerging as a valuable option in the management of this disease. In Europe, etanercept has recently been approved for children aged 8 years and over. Data...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/1153415-S0-000000000-00000
更新日期：2010-01-01 00:00:00
abstract：:Superficial mycoses are becoming increasingly resistant to current antifungal medications. As alternative therapeutic options are limited, the increasing frequency of reports of antifungal resistance is alarming. This epidemic parallels the rise of antibiotic resistance; however, the significance of this problem has y...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.1007/s40257-020-00580-6
更新日期：2020-12-22 00:00:00
abstract：:Topical retapamulin (Altabax, Altargo) is the first pleuromutilin antibacterial approved for the treatment of uncomplicated superficial skin infections caused by Staphylococcus aureus (excluding methicillin-resistant S. aureus [MRSA]) and Streptococcus pyogenes in patients aged > or = 9 months. In the EU, retapamulin ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.2165/0128071-200809060-00010
更新日期：2008-01-01 00:00:00
abstract：:Mycobacterial organisms have re-emerged as an important cause of infectious disease worldwide. Both tuberculosis and nontuberculous mycobacterial infections remain endemic in many parts of the world and are becoming more common in patients with iatrogenic immunosuppression and HIV infection. The nontuberculous mycobac...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200910050-00001
更新日期：2009-01-01 00:00:00
abstract：:Darier's disease is a rare cutaneous disease with an autosomal dominant mode of inheritance. Greasy papules and plaques arise on the seborrheic areas and in the flexures and almost all patients have nail abnormalities. Acantholysis and dyskeratosis are the typical histological findings. The underlying defect is a resu...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200304020-00003
更新日期：2003-01-01 00:00:00
abstract：:Eruptive melanocytic nevi (EMN) is a phenomenon characterized by the sudden onset of nevi. Our objective was to compile all published reports of EMN to identify possible precipitating factors and to evaluate the clinical appearance and course. We conducted a systematic bibliographic search and selected 93 articles, re...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-019-00444-8
更新日期：2019-10-01 00:00:00
abstract：:Chronic venous insufficiency (CVI) occurs in a relatively large proportion of the population and is associated with significant morbidity, high cost of healthcare, loss of productivity and reduced quality of life. Lower extremity ulcers related to CVI have been estimated to affect 0.2-1% of the population in developed...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200304080-00007
更新日期：2003-01-01 00:00:00
abstract：:In monosymptomatic hypochondriacal psychosis (MHP), such as delusional infestation (DI), the patient has a fixed, false, encapsulated belief associated with tactile hallucinations (TH), most commonly formication, which is defined as cutaneous sensations of crawling, stinging, biting, etc., without evidence of infestat...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-016-0219-z
更新日期：2016-12-01 00:00:00
abstract：:The dermis normally directs all phases of skin wound healing following tissue trauma or disease. However, in chronic wounds, the dermal matrix is insufficient to stimulate healing and assistance by external factors is needed for wound closure. Although the concept of the extracellular matrix directing wound healing is...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200708020-00001
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:5% topical minoxidil solution has been widely used to stimulate new hair growth and help stop hair loss in men with androgenetic alopecia (AGA). However, it is not convenient for patients to continue applying the solution twice daily on a regular basis. Tretinoin is known to increase the percutaneous absorpt...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,随机对照试验
doi：10.2165/00128071-200708050-00003
更新日期：2007-01-01 00:00:00
abstract：:Systemic sclerosis is an extremely variable disease in its manifestations and consequently, treatment needs to be individualized depending on the specific problems that each patient has. Limited scleroderma patients have a prolonged duration of Raynaud's phenomenon and puffy fingers before they develop any skin thicke...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200102050-00006
更新日期：2001-01-01 00:00:00
abstract：:Keratosis follicularis spinulosa decalvans is a rare, X-linked disorder characterized by scarring alopecia of the scalp and eyebrows in the setting of widespread keratosis pilaris. Less frequent associations are ocular abnormalities and palmoplantar keratoderma. Acne keloidalis nuchae has previously been described in ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.2165/00128071-200809020-00009
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:A few studies in psoriasis vulgaris patients have reported changes suggesting red blood cell (RBC) damage is linked to neutrophil activation, oxidative stress, and psoriasis worsening. OBJECTIVE:The aim of this study was to evaluate erythroid disturbances in Portuguese psoriasis vulgaris patients, before, d...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.2165/11592110-000000000-00000
更新日期：2012-02-01 00:00:00
abstract：UNLABELLED:Topical application of the antibacterial agent metronidazole is effective in the treatment of moderate to severe rosacea, although its mechanism of action has yet to be clearly established. Metronidazole preparations (0.75 and 1% cream, 0.75% gel and 0.75% lotion) were significantly more effective than place...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200001030-00007
更新日期：2000-05-01 00:00:00
abstract：:Erythema nodosum (EN) is the most common form of panniculitis. It is characterized by erythematous, raised, tender nodules that usually occur bilaterally on the extensor surfaces of the lower extremities. EN is associated with many underlying conditions including infection, sarcoidosis, malignancy, and pregnancy. Its ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-013-0024-x
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND:Probiotic, prebiotic, and synbiotic supplementation is becoming more prevalent nowadays. Clinical studies have demonstrated some of the medical benefits of probiotics, prebiotics, and synbiotics within dermatology but an evidence-based review of their effects in adults is needed. OBJECTIVE:The aim of this s...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-017-0300-2
更新日期：2017-12-01 00:00:00
abstract：:Alopecia areata (AA) is non-scarring hair loss resulting from an autoimmune disorder. Severity varies from patchy hair loss that often spontaneously resolves to severe and chronic cases that can progress to total loss of scalp and body hair. Many treatments are available; however, the efficacy of these treatments has ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-016-0230-4
更新日期：2017-02-01 00:00:00
abstract：:Genital herpes, an incurable viral disease that can have a devastating impact on affected patients, is a serious public health concern affecting one in four Americans. Episodic treatment with nucleoside analogs for 3-5 days is the most common method of treatment; however, since maximum viral replication occurs within ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,随机对照试验,评审
doi：10.2165/00128071-200607040-00001
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Confluent and reticulate papillomatosis of Gougerot and Carteaud (CRP) is a rare dermatological condition, which has not been reported widely in Asian populations. AIM:To characterize the clinicopathological and diagnostic features of CRP in a South-East Asian population. METHODS:The medical records of 29 ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.1007/s40257-014-0110-8
更新日期：2015-04-01 00:00:00
abstract：:Birt-Hogg-Dubé syndrome (BHD) is an autosomal dominant genodermatosis with malignant potential characterized by cutaneous and extracutaneous stigmata. Aberrations in the folliculin (FLCN) gene, which is located on chromosome 17, have been discovered in individuals with this condition. Over 150 unique mutations have be...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-017-0307-8
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Information on the factors that influence treatment management decisions for psoriatic arthritis (PsA) is limited. OBJECTIVE:Our objective was to evaluate the impact of clinical specialty setting and geographic region on the management of patients with PsA in the USA. METHODS:LOOP was a multicenter, cross-...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,多中心研究
doi：10.1007/s40257-019-00470-6
更新日期：2019-12-01 00:00:00
abstract：:Ocular diseases associated with atopic dermatitis (AD) may be sight-threatening. A general understanding of the pathophysiology, diagnosis, and treatment of atopic eye disease may assist dermatologists in knowing when to refer to ophthalmology and in co-managing these diseases with ophthalmologists. Ocular diseases as...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-019-00455-5
更新日期：2019-12-01 00:00:00
abstract：:Skin disorders are the most common adverse reactions attributed to drugs. Any skin disorder can be imitated, induced or aggravated by drugs. To help you keep up-to-date with the very latest skin reactions occurring with both new and established drugs, this section of the journal brings you information selected from th...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200304070-00007
更新日期：2003-01-01 00:00:00
