Risk of Suicidality in People with Psoriasis: A Systematic Review and Meta-Analysis of Cohort Studies.

Abstract:

BACKGROUND:Psoriasis has been associated with psychiatric disorders such as depression and anxiety, but its relationship with suicidality (including suicide, suicide attempt, and suicidal ideation) is unclear. OBJECTIVE:Our objective was to assess the risk of suicide, suicide attempt, suicidal ideation, and suicidality in people with psoriasis. METHODS:We conducted a systematic review and meta-analysis of cohort studies examining the risk of suicide, suicide attempt, suicidal ideation, and suicidality in people with psoriasis. We searched the Cochrane Library, PubMed, and EMBASE from inception to 24 March 2017. Two authors independently selected studies, assessed the quality of included studies, and extracted data. Any disagreement was resolved by discussion with a third author. RESULTS:Five population-based cohort studies were included and considered to be of high quality. We found no increase in the risk of suicide (risk ratio [RR] 1.13; 95% confidence interval [CI] 0.87-1.46), suicide attempt (RR 1.25; 95% CI 0.89-1.75), or suicidality (RR 1.26; 95% CI 0.97-1.64) among people with psoriasis. In the stratified analysis, we also found no increase in suicide, suicide attempt, and suicidality among people with either severe or mild psoriasis. CONCLUSIONS:The available limited, very low-quality evidence does not support an association between psoriasis and suicidal thought and behavior. Further studies that provide data for different age and sex groups are needed to clarify whether a subgroup of patients with psoriasis has an elevated risk of suicidality.

journal_name

Am J Clin Dermatol

authors

Chi CC,Chen TH,Wang SH,Tung TH

doi

10.1007/s40257-017-0281-1

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

621-627

issue

5

eissn

1175-0561

issn

1179-1888

pii

10.1007/s40257-017-0281-1

journal_volume

18

pub_type

杂志文章,meta分析,评审
  • Role of topical calcineurin inhibitors in the treatment of seborrheic dermatitis: a review of pathophysiology, safety, and efficacy.

    abstract::Seborrheic dermatitis (SD) is characterized by erythematous pruritic patches and plaques with greasy scale that occur in sebaceous areas. It is common, affecting up to 3% of the population. Past treatments have relied on a wide variety of anti-inflammatory and antifungal agents, but corticosteroids have limited use be...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200910020-00003

    authors: Cook BA,Warshaw EM

    更新日期:2009-01-01 00:00:00

  • Peroxisome proliferator-activated receptors (PPARs) and the human skin: importance of PPARs in skin physiology and dermatologic diseases.

    abstract::Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily that regulate lipid, glucose, and amino acid metabolism. More recently, PPARs and corresponding ligands have been shown in skin and other organs to regulate important cellular functions, including cell proliferation and...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200809010-00002

    authors: Sertznig P,Seifert M,Tilgen W,Reichrath J

    更新日期:2008-01-01 00:00:00

  • Topical halobetasol propionate in the treatment of plaque psoriasis: a review.

    abstract::Halobetasol propionate (HP) 0.5% ointment and cream are class I topical corticosteroids. We review the efficacy and tolerability of HP for treatment of plaque psoriasis in the English language literature. The efficacy of HP ointment and cream is consistently superior to other super-potent topical corticosteroids. Loca...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200506050-00004

    authors: Rivera AM,Hsu S

    更新日期:2005-01-01 00:00:00

  • Trigeminal trophic syndrome from stroke: an under-recognized central neuropathic itch syndrome.

    abstract::Trigeminal trophic syndrome (TTS) is the historic name for neuropathic self-induced facial ulceration from abnormal sensory symptoms leading to uncontrolled scratching. Anatomic co-localization of sensory loss (numbness) plus neuropathic itch and pain permits painless scratching. If the itch is severe, some patients w...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章

    doi:10.2165/11594060-000000000-00000

    authors: Curtis AR,Oaklander AL,Johnson A,Yosipovitch G

    更新日期:2012-04-01 00:00:00

  • Primary Cutaneous Coccidioidomycosis: An Update.

    abstract::Coccidioidomycosis is an endemic mycosis of the southern United States, Northern Mexico, and South America. Primary cutaneous coccidioidomycosis, despite being a very rare clinical presentation, has shown an increasing incidence. An extensive literature search for cutaneous coccidioidomycosis cases was performed using...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.1007/s40257-020-00525-z

    authors: Reyna-Rodríguez IL,Ocampo-Candiani J,Chavez-Alvarez S

    更新日期:2020-10-01 00:00:00

  • The Future of Molecular Analysis in Melanoma: Diagnostics to Direct Molecularly Targeted Therapy.

    abstract::Melanoma is a malignancy of pigment-producing cells that is driven by a variety of genetic mutations and aberrations. In most cases, this leads to upregulation of the mitogen-activated protein kinase (MAPK) pathway through activating mutations of upstream mediators of the pathway including BRAF and NRAS. With the adve...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.1007/s40257-015-0159-z

    authors: Akabane H,Sullivan RJ

    更新日期:2016-02-01 00:00:00

  • Postinflammatory hyperpigmentation: etiologic and therapeutic considerations.

    abstract::Postinflammatory hyperpigmentation (PIH) is a reactive hypermelanosis and sequela of a variety of inflammatory skin conditions. PIH can have a negative impact on a patient's quality of life, particularly for darker-skinned patients. Studies show that dyschromias, including PIH, are one of the most common presenting co...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/11536930-000000000-00000

    authors: Callender VD,St Surin-Lord S,Davis EC,Maclin M

    更新日期:2011-04-01 00:00:00

  • Ocular Co-Morbidities of Atopic Dermatitis. Part I: Associated Ocular Diseases.

    abstract::Ocular diseases associated with atopic dermatitis (AD) may be sight-threatening. A general understanding of the pathophysiology, diagnosis, and treatment of atopic eye disease may assist dermatologists in knowing when to refer to ophthalmology and in co-managing these diseases with ophthalmologists. Ocular diseases as...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.1007/s40257-019-00455-5

    authors: Beck KM,Seitzman GD,Yang EJ,Sanchez IM,Liao W

    更新日期:2019-12-01 00:00:00

  • Fragrance contact allergy: a clinical review.

    abstract::Most people in modern society are exposed daily to fragrance ingredients from one or more sources. Fragrance ingredients are also one of the most frequent causes of contact allergic reactions. The diagnosis is made by patch testing with a mixture of fragrance ingredients, the fragrance mix. This gives a positive patch...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200304110-00006

    authors: Johansen JD

    更新日期:2003-01-01 00:00:00

  • Efficacy of 5% minoxidil versus combined 5% minoxidil and 0.01% tretinoin for male pattern hair loss: a randomized, double-blind, comparative clinical trial.

    abstract:BACKGROUND:5% topical minoxidil solution has been widely used to stimulate new hair growth and help stop hair loss in men with androgenetic alopecia (AGA). However, it is not convenient for patients to continue applying the solution twice daily on a regular basis. Tretinoin is known to increase the percutaneous absorpt...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,随机对照试验

    doi:10.2165/00128071-200708050-00003

    authors: Shin HS,Won CH,Lee SH,Kwon OS,Kim KH,Eun HC

    更新日期:2007-01-01 00:00:00

  • Cutaneous drug reaction case reports: from the world literature.

    abstract::Skin disorders are the most common adverse reactions attributed to drugs. Any skin disorder can be imitated, induced or aggravated by drugs. To help you keep up-to-date with the very latest skin reactions occurring with both new and established drugs, this section of the journal brings you information selected from th...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章

    doi:10.2165/00128071-200304050-00006

    authors:

    更新日期:2003-01-01 00:00:00

  • Thalidomide in cutaneous lupus erythematosus.

    abstract::For nearly 50 years, thalidomide has struggled between success and controversy. After causing an epidemic of phocomelia and other birth defects during the 1960s, affecting thousands of neonates, thalidomide was used as a sedative in selective disorders including leprosy. The potent anti-inflammatory properties of thal...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200304060-00002

    authors: Pelle MT,Werth VP

    更新日期:2003-01-01 00:00:00

  • Radiation-recall skin disorders associated with the use of antineoplastic drugs. Pathogenesis, prevalence, and management.

    abstract::Radiation-recall dermatitis is the occurrence, with subsequent administration of cytotoxic chemotherapy, of an acute inflammatory toxicity in a previously quiescent radiation field. It may occur from days to weeks, and sometimes years, after the radiation therapy. The precise mechanism is unknown. One hypothesis sugge...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200001020-00006

    authors: Yeo W,Johnson PJ

    更新日期:2000-03-01 00:00:00

  • Anti-IL-17 Medications Used in the Treatment of Plaque Psoriasis and Psoriatic Arthritis: A Comprehensive Review.

    abstract::Our ability to successfully treat patients with moderate to severe psoriasis has improved significantly over the last several years with the development of more targeted therapies. IL-17A, a member of the IL-17 family of interleukins, is involved in regulating the innate and adaptive immune systems and has been identi...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.1007/s40257-015-0162-4

    authors: Canavan TN,Elmets CA,Cantrell WL,Evans JM,Elewski BE

    更新日期:2016-02-01 00:00:00

  • Etanercept therapy for psoriasis in a patient with numerous comorbidities.

    abstract::A recent study demonstrated an association between psoriasis and dilated cardiomyopathy. Tumour necrosis factor alpha (TNFalpha) may be involved in the pathogenesis of dilated cardiomyopathy and therefore, anti-TNFalpha agents may play a role in the treatment of dilated cardiomyopathy. The case of a 51-year-old woman ...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章

    doi:10.2165/1153425-S0-000000000-00000

    authors: De Simone C,Carbone A,Caldarola G

    更新日期:2010-01-01 00:00:00

  • Effects of airbag deployment: lesions, epidemiology, and management.

    abstract::Airbags are restraining safety devices, but their activation may sometimes induce injuries during road accidents. Rapid deceleration due to an impact causes the ignition of a sodium azide cartridge, which releases nitrogen gas to inflate the nylon rubber bag. Numerous high-temperature gases, sodium hydroxide, carbon d...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200405050-00002

    authors: Corazza M,Trincone S,Virgili A

    更新日期:2004-01-01 00:00:00

  • Topical metronidazole. A review of its use in rosacea.

    abstract:UNLABELLED:Topical application of the antibacterial agent metronidazole is effective in the treatment of moderate to severe rosacea, although its mechanism of action has yet to be clearly established. Metronidazole preparations (0.75 and 1% cream, 0.75% gel and 0.75% lotion) were significantly more effective than place...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200001030-00007

    authors: McClellan KJ,Noble S

    更新日期:2000-05-01 00:00:00

  • Patients' vehicle preference for corticosteroid treatments of scalp psoriasis.

    abstract::Topical therapy is one of the foundations of dermatology. The vehicles used to deliver topical therapy have considerable impact on efficacy. The vehicle can have direct effects on disease; it can impact the delivery of the active drug, and its characteristics affect patient compliance. While the physical chemistry of ...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章

    doi:10.2165/00128071-200304040-00001

    authors: Feldman SR,Housman TS

    更新日期:2003-01-01 00:00:00

  • Efficacy and tolerability of a cosmetically acceptable coal tar solution in the treatment of moderate plaque psoriasis: a controlled comparison with calcipotriene (calcipotriol) cream.

    abstract:BACKGROUND:Topical coal tar is a well known and effective treatment for psoriasis, but the messiness, staining, odor, and inconvenience associated with its use make patient satisfaction and compliance a challenge. OBJECTIVE:To determine the efficacy, patient tolerability, and cosmetic acceptability of a new topical li...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,随机对照试验

    doi:10.2165/11530380-000000000-00000

    authors: Alora-Palli MB,Perkins AC,Van Cott A,Kimball AB

    更新日期:2010-01-01 00:00:00

  • Spotlight on retapamulin in impetigo and other uncomplicated superficial skin infections.

    abstract::Topical retapamulin (Altabax, Altargo) is the first pleuromutilin antibacterial approved for the treatment of uncomplicated superficial skin infections caused by Staphylococcus aureus (excluding methicillin-resistant S. aureus [MRSA]) and Streptococcus pyogenes in patients aged > or = 9 months. In the EU, retapamulin ...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章

    doi:10.2165/0128071-200809060-00010

    authors: Yang LP,Keam SJ

    更新日期:2008-01-01 00:00:00

  • Management of oral lichen planus.

    abstract::Lichen planus is a relatively common disorder of the stratified squamous epithelia. Most dental and medical practitioners see patients with lichen planus, but not all are recognized as having the disease. Patients with lichen planus may have concomitant involvement of the disease in multiple sites. Oral lichen planus ...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200001050-00004

    authors: Scully C,Eisen D,Carrozzo M

    更新日期:2000-09-01 00:00:00

  • Assessing quality of life in patients with acne vulgaris: implications for treatment.

    abstract::Diagnosing acne is easy. However, treatment must be adapted to the type and severity of acne, and must also take into account the impact of acne on patients' quality of life. As there is not always a correlation between the severity of acne and its impact on quality of life, it can be helpful for the dermatologist to ...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200607020-00003

    authors: Dréno B

    更新日期:2006-01-01 00:00:00

  • Adalimumab: A Review in Hidradenitis Suppurativa.

    abstract::Subcutaneous adalimumab (Humira®) is a tumour necrosis factor-α blocker that is the only approved agent for the treatment of moderate to severe hidradenitis suppurativa (HS) in several countries worldwide. This article reviews the clinical efficacy and safety of subcutaneous adalimumab in patients with moderate to sev...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.1007/s40257-016-0220-6

    authors: Kim ES,Garnock-Jones KP,Keam SJ

    更新日期:2016-10-01 00:00:00

  • Photodynamic therapy: is it a valuable treatment option for actinic keratoses?

    abstract::Photodynamic therapy (PDT) is proposed as an effective therapy with a good safety profile for patients with actinic keratoses. PDT involves the application of a photosensitizer to dysplastic or neoplastic tissue such that when exposed to light of an appropriate wavelength, the target tissue undergoes a cytotoxic react...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200304030-00001

    authors: Chamberlain AJ,Kurwa HA

    更新日期:2003-01-01 00:00:00

  • Videodermatoscopy enhances diagnostic capability in some forms of hair loss.

    abstract:BACKGROUND:Videodermatoscopy is a non-invasive technique that allows in vivo skin observation at high magnifications. OBJECTIVE:The goal of this study was to determine if videodermatoscopy enhances diagnostic capability beyond standard clinical observation in three series of patients: one group of patients with overt ...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章

    doi:10.2165/00128071-200405030-00009

    authors: Lacarrubba F,Dall'Oglio F,Rita Nasca M,Micali G

    更新日期:2004-01-01 00:00:00

  • Paraneoplastic erythema annulare centrifugum eruption: PEACE.

    abstract::Erythema annulare centrifugum is a reactive erythema of various possible etiologies including, although less often, an associated cancer. Cancer-related erythema annulare centrifugum is most commonly associated with lymphoproliferative malignancies, specifically lymphoma and leukemia. Malignancy-associated erythema an...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/11596580-000000000-00000

    authors: Chodkiewicz HM,Cohen PR

    更新日期:2012-08-01 00:00:00

  • Cutaneous drug reaction case reports: from the world literature.

    abstract::Skin disorders are the most common adverse reactions attributed to drugs. Any skin disorder can be imitated, induced or aggravated by drugs. To help you keep up-to-date with the very latest skin reactions occurring with both new and established drugs, this section of the journal brings you information selected from th...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200304070-00007

    authors:

    更新日期:2003-01-01 00:00:00

  • Clinicopathological and diagnostic characterization of confluent and reticulate papillomatosis of Gougerot and Carteaud: a retrospective study in a South-East Asian population.

    abstract:BACKGROUND:Confluent and reticulate papillomatosis of Gougerot and Carteaud (CRP) is a rare dermatological condition, which has not been reported widely in Asian populations. AIM:To characterize the clinicopathological and diagnostic features of CRP in a South-East Asian population. METHODS:The medical records of 29 ...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章

    doi:10.1007/s40257-014-0110-8

    authors: Huang W,Ong G,Chong WS

    更新日期:2015-04-01 00:00:00

  • Optimal management of acne to prevent scarring and psychological sequelae.

    abstract::Acne vulgaris is one of the most common inflammatory dermatoses and is seen in both the hospital setting and in general practice. Multiple factors are involved in the pathophysiology of acne, including: an alteration in the pattern of keratinization within the pilosebaceous follicles resulting in comedone formation; a...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200102030-00002

    authors: Layton AM

    更新日期:2001-01-01 00:00:00

  • Non-infectious granulomatous diseases of the skin and their associated systemic diseases: an evidence-based update to important clinical questions.

    abstract::Non-infectious granulomatous diseases of the skin are a broad group of distinct reactive inflammatory conditions that share important similarities. As a group, they are relatively difficult to diagnose and distinguish both clinically as well as histologically. Many of these disorders have significant associations with...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/11530080-000000000-00000

    authors: Hawryluk EB,Izikson L,English JC 3rd

    更新日期:2010-01-01 00:00:00