Abstract:
:Topical retapamulin (Altabax, Altargo) is the first pleuromutilin antibacterial approved for the treatment of uncomplicated superficial skin infections caused by Staphylococcus aureus (excluding methicillin-resistant S. aureus [MRSA]) and Streptococcus pyogenes in patients aged > or = 9 months. In the EU, retapamulin is indicated for use in patients with impetigo or with infected small lacerations, abrasions, or sutured wounds (without abscesses); in the US, it is indicated for use in patients with impetigo. Retapamulin has a novel site of action on bacterial ribosomes. In clinical trials in patients with impetigo, topical retapamulin 1% ointment twice daily for 5 days (the approved regimen) was superior to placebo; treatment with retapamulin was noninferior to that with topical fusidic acid. In patients with secondarily infected traumatic lesions, treatment with retapamulin was noninferior to that with oral cephalexin, although the efficacy of retapamulin was reduced in patients with MRSA infections or superficial abscesses. Retapamulin was well tolerated in both pediatric and adult patients, and the majority of adverse events were of mild to moderate severity. Thus, the introduction of topical retapamulin 1% ointment extends the treatment options available in the management of impetigo and uncomplicated secondarily infected traumatic lesions.
journal_name
Am J Clin Dermatoljournal_title
American journal of clinical dermatologyauthors
Yang LP,Keam SJdoi
10.2165/0128071-200809060-00010subject
Has Abstractpub_date
2008-01-01 00:00:00pages
411-3issue
6eissn
1175-0561issn
1179-1888pii
9610journal_volume
9pub_type
杂志文章abstract::Occupational contact dermatitis (OCD) represents 90 to 95% of all occupational dermatoses. The incidence rate of OCD is estimated to be around 0.5 to 1.9 cases per full-time worker per year. However, epidemiologic data are lacking and incidence is probably underestimated, especially in the US. Over the past 20 years, ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200102060-00002
更新日期:2001-01-01 00:00:00
abstract::In monosymptomatic hypochondriacal psychosis (MHP), such as delusional infestation (DI), the patient has a fixed, false, encapsulated belief associated with tactile hallucinations (TH), most commonly formication, which is defined as cutaneous sensations of crawling, stinging, biting, etc., without evidence of infestat...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-016-0219-z
更新日期:2016-12-01 00:00:00
abstract::Diagnosing acne is easy. However, treatment must be adapted to the type and severity of acne, and must also take into account the impact of acne on patients' quality of life. As there is not always a correlation between the severity of acne and its impact on quality of life, it can be helpful for the dermatologist to ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200607020-00003
更新日期:2006-01-01 00:00:00
abstract::After a marked decline in the number of syphilis cases in the context of AIDS prevention campaigns, a significant increase has been observed in states of the former Soviet Union since 1994. In recent years, outbreaks have also been reported in the US, Canada, and several European countries. The current epidemic in the...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200607050-00003
更新日期:2006-01-01 00:00:00
abstract::Skin disorders are the most common adverse reactions attributed to drugs. Any skin disorder can be imitated, induced or aggravated by drugs. To help you keep up-to-date with the very latest skin reactions occurring with both new and established drugs, this section of the journal brings you information selected from th...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200203070-00009
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Information on the factors that influence treatment management decisions for psoriatic arthritis (PsA) is limited. OBJECTIVE:Our objective was to evaluate the impact of clinical specialty setting and geographic region on the management of patients with PsA in the USA. METHODS:LOOP was a multicenter, cross-...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,多中心研究
doi:10.1007/s40257-019-00470-6
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Probiotic, prebiotic, and synbiotic supplementation is becoming more prevalent nowadays. Clinical studies have demonstrated some of the medical benefits of probiotics, prebiotics, and synbiotics within dermatology but an evidence-based review of their effects in adults is needed. OBJECTIVE:The aim of this s...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-017-0300-2
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:The relationship between psoriasis and vitiligo has not been previously confirmed, and we therefore aimed to investigate this association. METHODS:We conducted a search of the MEDLINE and EMBASE electronic databases on 22 January 2018 for case-control, cross-sectional, and cohort studies examining the assoc...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,meta分析
doi:10.1007/s40257-018-0394-1
更新日期:2019-02-01 00:00:00
abstract::The solar radiation range has harmful and beneficial effects. Sunscreens, which selectively block specific spectral regions, may potentially interfere with skin homeostasis. For instance, the ultraviolet (UV) B waveband produces erythema and DNA damage; simultaneously, it induces pre-vitamin D3 synthesis. UVA1 and vis...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-018-0369-2
更新日期:2018-11-01 00:00:00
abstract::Systemic sclerosis is an extremely variable disease in its manifestations and consequently, treatment needs to be individualized depending on the specific problems that each patient has. Limited scleroderma patients have a prolonged duration of Raynaud's phenomenon and puffy fingers before they develop any skin thicke...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200102050-00006
更新日期:2001-01-01 00:00:00
abstract::Aggressive digital papillary adenocarcinoma (ADPAC) is a rare cutaneous malignant tumor. We report on a 42-year-old man presenting with a nontender firm nodule on his right thumb that had been present for 3 years. The lesion clinically resembled an acquired digital fibrokeratoma, but was found to be an ADPAC after pat...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/00128071-200708040-00007
更新日期:2007-01-01 00:00:00
abstract::Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous tumor with a predilection for the head and neck of elderly Caucasian patients. Although much less common than melanoma, MCC has higher rates of sentinel lymph node involvement, local and regional recurrences, and mortality. The majority of MCC cases have b...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-015-0163-3
更新日期:2016-02-01 00:00:00
abstract::Mycobacterial organisms have re-emerged as an important cause of infectious disease worldwide. Both tuberculosis and nontuberculous mycobacterial infections remain endemic in many parts of the world and are becoming more common in patients with iatrogenic immunosuppression and HIV infection. The nontuberculous mycobac...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200910050-00001
更新日期:2009-01-01 00:00:00
abstract::Granular parakeratosis (GP) is a rare, idiopathic, and benign skin condition that presents classically as erythematous to brown hyperkeratotic papules that can coalesce into plaques. Axillary GP was initially observed by Northcutt and colleagues and has since been described in various other areas of the body including...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-015-0148-2
更新日期:2015-12-01 00:00:00
abstract::Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that may be caused by an adverse drug reaction. We discuss the clinical presentation and outcomes of 52 cases of drug-induced PG reported to date in the literature. We conducted our literature search for case reports of drug-induced PG using keywords on PubMe...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-017-0308-7
更新日期:2018-02-01 00:00:00
abstract::Seborrheic dermatitis (SD) is characterized by erythematous pruritic patches and plaques with greasy scale that occur in sebaceous areas. It is common, affecting up to 3% of the population. Past treatments have relied on a wide variety of anti-inflammatory and antifungal agents, but corticosteroids have limited use be...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200910020-00003
更新日期:2009-01-01 00:00:00
abstract::Halobetasol propionate (HP) 0.5% ointment and cream are class I topical corticosteroids. We review the efficacy and tolerability of HP for treatment of plaque psoriasis in the English language literature. The efficacy of HP ointment and cream is consistently superior to other super-potent topical corticosteroids. Loca...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200506050-00004
更新日期:2005-01-01 00:00:00
abstract:UNLABELLED:Topical application of the antibacterial agent metronidazole is effective in the treatment of moderate to severe rosacea, although its mechanism of action has yet to be clearly established. Metronidazole preparations (0.75 and 1% cream, 0.75% gel and 0.75% lotion) were significantly more effective than place...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200001030-00007
更新日期:2000-05-01 00:00:00
abstract::The etiologies of a variety of skin conditions associated with diabetes have not been fully explained. One possible etiological factor is diabetic microangiopathy, which is known to affect the eyes and kidneys in patients with diabetes. There are many mechanisms by which diabetes may cause microangiopathy. These inclu...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200506040-00003
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Dementia is a syndrome that involves the deterioration of several higher mental functions in advanced age, and psoriasis is an autoimmune disease characterized by skin plaque. Epidemiological studies have indicated an association between dementia and psoriasis; however, to date, no studies in Asia have repor...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.1007/s40257-018-00420-8
更新日期:2019-06-01 00:00:00
abstract::Psoriasis is a chronic inflammatory systemic disease associated with an important physical and physiological burden. It primarily affects the skin, but it is associated with several serious medical co-morbidities. One third of total psoriatic cases have their onset during the pediatric age, although some of them may n...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-017-0294-9
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Confluent and reticulate papillomatosis of Gougerot and Carteaud (CRP) is a rare dermatological condition, which has not been reported widely in Asian populations. AIM:To characterize the clinicopathological and diagnostic features of CRP in a South-East Asian population. METHODS:The medical records of 29 ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.1007/s40257-014-0110-8
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Evidence regarding what comprises effective education for acne vulgaris patients is lacking. Internet-based education may improve patient knowledge of this condition. OBJECTIVES:Our objective was to compare the effectiveness of standard web-based education and an automated counseling website in improving ac...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s40257-014-0104-6
更新日期:2015-02-01 00:00:00
abstract::There is a high unmet clinical need for new and better treatments in acne vulgaris. Propionibacterium acnes has a strong proinflammatory activity and targets molecules involved in the innate cutaneous immunity, keratinocytes and sebaceous glands of the pilosebaceous follicle. The role of P. acnes in acne confers legit...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-013-0042-8
更新日期:2013-12-01 00:00:00
abstract::Most people in modern society are exposed daily to fragrance ingredients from one or more sources. Fragrance ingredients are also one of the most frequent causes of contact allergic reactions. The diagnosis is made by patch testing with a mixture of fragrance ingredients, the fragrance mix. This gives a positive patch...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200304110-00006
更新日期:2003-01-01 00:00:00
abstract::Genital herpes, an incurable viral disease that can have a devastating impact on affected patients, is a serious public health concern affecting one in four Americans. Episodic treatment with nucleoside analogs for 3-5 days is the most common method of treatment; however, since maximum viral replication occurs within ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,随机对照试验,评审
doi:10.2165/00128071-200607040-00001
更新日期:2006-01-01 00:00:00
abstract::Superficial fungal infections are chronic and recurring conditions. Tinea capitis is a scalp infection, primarily affecting prepubescent children. Ringworm infections, such as tinea corporis and tinea cruris, involve the glabrous skin. Tinea nigra is a rare mycotic infection that may be related to travel abroad. Piedr...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200405040-00003
更新日期:2004-01-01 00:00:00
abstract::Cutaneous reactions to tattoos are not uncommon and various histologic patterns have been reported, including lichenoid, granulomatous, eczematous, and pseudolymphomatous reactions. Such patterns may develop with highly variable delay after the tattooing procedure. We report three strikingly similar cases of a fast-oc...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/00128071-200809050-00009
更新日期:2008-01-01 00:00:00
abstract::Topical pimecrolimus 1% cream (Elidel) [hereafter referred to as topical pimecrolimus] is a nonsteroidal alternative in the treatment of pediatric atopic dermatitis. In vehicle-controlled, short-term, continuous-use trials in pediatric patients with mild to moderate atopic dermatitis, topical pimecrolimus was effectiv...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/11204640-000000000-00000
更新日期:2010-01-01 00:00:00
abstract::Pemphigus vulgaris (PV) is a severe chronic autoimmune blistering disease that affects the skin and mucous membranes. It is characterized by suprabasal acantholysis due to disruption of desmosomal connections between keratinocytes. Autoantibodies against desmosomal cadherins, desmoglein 3 and 1, have been shown to ind...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.1007/s40257-020-00544-w
更新日期:2020-12-01 00:00:00