Abstract:
:In women, acne can be successfully treated with oral contraceptives. This article focuses on the results of clinical studies on the treatment of acne with oral contraceptives. From the literature, 12 such studies could be traced over the last 10 years. Most of the studies were multicenter, randomized, and double blind. Five studies were placebo controlled. All of these studies were analyzed and compared with each other. Statistically, all placebo-controlled studies showed a better result with the active treatment, than with the placebo. However, the placebo groups also showed an improvement in the acne lesions. In seven studies, two oral contraceptives were compared for their effect on acne vulgaris. All oral contraceptives studied showed a beneficial effect on the severity of acne. It can be concluded, based on these studies, that all oral contraceptives have a more or less beneficial effect on mild to moderate acne in women. Comparing the various clinical trials, ethinylestradiol/drospirenone is as good as ethinylestradiol/cyproterone, which is slightly better than ethinylestradiol/desogestrel and ethinylestradiol/gestodene. Ethinylestradiol/chlormadinone is slightly better than ethinylestradiol/levonorgestrel, which is as effective as ethinylestradiol/norethindrone, which is far better than the placebo. Ethinylestradiol/norgestimate is better than placebo.
journal_name
Am J Clin Dermatoljournal_title
American journal of clinical dermatologyauthors
van Vloten WA,Sigurdsson Vdoi
10.2165/00128071-200405060-00008subject
Has Abstractpub_date
2004-01-01 00:00:00pages
435-41issue
6eissn
1175-0561issn
1179-1888pii
568journal_volume
5pub_type
杂志文章,评审abstract::Our ability to successfully treat patients with moderate to severe psoriasis has improved significantly over the last several years with the development of more targeted therapies. IL-17A, a member of the IL-17 family of interleukins, is involved in regulating the innate and adaptive immune systems and has been identi...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-015-0162-4
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Based on the results of numerous preclinical and clinical studies, sertaconazole can be considered a safe and effective drug for the treatment of fungal skin infections. OBJECTIVE:The objective of the study was to compare the efficacy of a solution containing 2% sertaconazole with the well established 2% se...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2165/00128071-200708060-00007
更新日期:2007-01-01 00:00:00
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200304080-00007
更新日期:2003-01-01 00:00:00
abstract::Most people in modern society are exposed daily to fragrance ingredients from one or more sources. Fragrance ingredients are also one of the most frequent causes of contact allergic reactions. The diagnosis is made by patch testing with a mixture of fragrance ingredients, the fragrance mix. This gives a positive patch...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200304110-00006
更新日期:2003-01-01 00:00:00
abstract::Postinflammatory hyperpigmentation (PIH) is a reactive hypermelanosis and sequela of a variety of inflammatory skin conditions. PIH can have a negative impact on a patient's quality of life, particularly for darker-skinned patients. Studies show that dyschromias, including PIH, are one of the most common presenting co...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/11536930-000000000-00000
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abstract::Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that may be caused by an adverse drug reaction. We discuss the clinical presentation and outcomes of 52 cases of drug-induced PG reported to date in the literature. We conducted our literature search for case reports of drug-induced PG using keywords on PubMe...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-017-0308-7
更新日期:2018-02-01 00:00:00
abstract::Ocular diseases associated with atopic dermatitis (AD) may be sight-threatening. A general understanding of the pathophysiology, diagnosis, and treatment of atopic eye disease may assist dermatologists in knowing when to refer to ophthalmology and in co-managing these diseases with ophthalmologists. Ocular diseases as...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-019-00455-5
更新日期:2019-12-01 00:00:00
abstract::Pantothenic acid is essential to normal epithelial function. It is a component of coenzyme A, which serves as a cofactor for a variety of enzyme-catalyzed reactions that are important in the metabolism of carbohydrates, fatty acids, proteins, gluconeogenesis, sterols, steroid hormones, and porphyrins. The topical use ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200203060-00005
更新日期:2002-01-01 00:00:00
abstract::Ultrapotent topical corticosteroids are the mainstay of psoriasis treatment, used either alone or in combination with a topical vitamin D analog. Traditionally used in an ointment vehicle for psoriasis, clobetasol propionate 0.05% is also available in spray, foam, lotion, and shampoo formulations, which may provide fo...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/11311020-000000000-00000
更新日期:2009-01-01 00:00:00
abstract::Hyperhidrosis is a common and distressing condition involving increased production of sweat. A variety of treatment modalities are used to try to control or reduce sweating. Sweat is secreted by eccrine glands innervated by cholinergic fibers from the sympathetic nervous system. Primary hyperhidrosis most commonly aff...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200304100-00003
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Information on the factors that influence treatment management decisions for psoriatic arthritis (PsA) is limited. OBJECTIVE:Our objective was to evaluate the impact of clinical specialty setting and geographic region on the management of patients with PsA in the USA. METHODS:LOOP was a multicenter, cross-...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,多中心研究
doi:10.1007/s40257-019-00470-6
更新日期:2019-12-01 00:00:00
abstract::Skin disorders are the most common adverse reactions attributed to drugs. Any skin disorder can be imitated, induced or aggravated by drugs. To help you keep up-to-date with the very latest skin reactions occurring with both new and established drugs, this section of the journal brings you information selected from th...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200304070-00007
更新日期:2003-01-01 00:00:00
abstract::Chronic itch is a common skin manifestation in many connective tissue diseases. However, the cause of chronic itch in these diseases is still not fully understood. The complex, and in some cases incomplete understanding of, pathogenesis in each condition makes it difficult to target specific mediators of chronic itch....
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-016-0201-9
更新日期:2016-10-01 00:00:00
abstract::Vitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproductive diseases, infections, and autoimmune and dermatological disorders. The two main sources of vitamin D are sun exposure and oral intake, including vitamin D supplementation and dietary intake. Mult...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-017-0323-8
更新日期:2018-04-01 00:00:00
abstract::Vulvar lichen sclerosus is an important skin disease that is common in women in their 50 s and beyond; however, it can also affect females of any age, including children. If not treated, it has the potential to cause significant and permanent scarring and deformity of the vulvar structure. In addition, if untreated, i...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-018-0364-7
更新日期:2018-10-01 00:00:00
abstract::Halobetasol propionate (HP) 0.5% ointment and cream are class I topical corticosteroids. We review the efficacy and tolerability of HP for treatment of plaque psoriasis in the English language literature. The efficacy of HP ointment and cream is consistently superior to other super-potent topical corticosteroids. Loca...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200506050-00004
更新日期:2005-01-01 00:00:00
abstract::Tumor necrosis factor (TNF)-α inhibitors are an alternative to oral systemic therapies for psoriasis. Data regarding the safety of TNF-α inhibitors from randomized clinical trials may not fully reflect the effects on the clinic patient population receiving the therapy, but other sources of information are available. W...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-013-0053-5
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Methotrexate (MTX) is an effective treatment for psoriasis but its use is limited by its toxicity. Folate supplementation can be used to reduce the adverse effects of MTX, though this may impact efficacy. The frequency of folic acid supplementation is not well characterized. PURPOSE:The objective of this st...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-013-0017-9
更新日期:2013-06-01 00:00:00
abstract::Superficial mycoses are becoming increasingly resistant to current antifungal medications. As alternative therapeutic options are limited, the increasing frequency of reports of antifungal resistance is alarming. This epidemic parallels the rise of antibiotic resistance; however, the significance of this problem has y...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
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更新日期:2020-12-22 00:00:00
abstract::The family of toll-like receptors (TLRs) plays a central role in the cutaneous immune defense system. To date, different TLRs have been found on several major cell populations of the skin, such as keratinocytes, fibroblasts, antigen-presenting cells, and melanocytes. Activation of TLRs leads, via different intracellul...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/11311110-000000000-00000
更新日期:2010-01-01 00:00:00
abstract::Recent advances in our understanding of the pathophysiology of atopic dermatitis (AD) have revealed that skin microbiome dysbiosis plays an important role in the disease. In this review, we describe how changes in the structure and function of the microbiome are involved in the pathogenesis of AD. We highlight recent ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
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更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Topical coal tar is a well known and effective treatment for psoriasis, but the messiness, staining, odor, and inconvenience associated with its use make patient satisfaction and compliance a challenge. OBJECTIVE:To determine the efficacy, patient tolerability, and cosmetic acceptability of a new topical li...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,随机对照试验
doi:10.2165/11530380-000000000-00000
更新日期:2010-01-01 00:00:00
abstract::Keratosis follicularis spinulosa decalvans is a rare, X-linked disorder characterized by scarring alopecia of the scalp and eyebrows in the setting of widespread keratosis pilaris. Less frequent associations are ocular abnormalities and palmoplantar keratoderma. Acne keloidalis nuchae has previously been described in ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/00128071-200809020-00009
更新日期:2008-01-01 00:00:00
abstract::At least 20 clinically relevant factors affect percutaneous absorption of drugs and chemicals: relevant physico-chemical properties, vehicle/formulation, drug exposure conditions (dose, duration, surface area, exposure frequency), skin appendages (hair follicles, glands) as sub-anatomical pathways, skin application si...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-019-00480-4
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Videodermatoscopy is a non-invasive technique that allows in vivo skin observation at high magnifications. OBJECTIVE:The goal of this study was to determine if videodermatoscopy enhances diagnostic capability beyond standard clinical observation in three series of patients: one group of patients with overt ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/00128071-200405030-00009
更新日期:2004-01-01 00:00:00
abstract::Granular parakeratosis (GP) is a rare, idiopathic, and benign skin condition that presents classically as erythematous to brown hyperkeratotic papules that can coalesce into plaques. Axillary GP was initially observed by Northcutt and colleagues and has since been described in various other areas of the body including...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-015-0148-2
更新日期:2015-12-01 00:00:00
abstract::Of all the psychotropic medications currently available, the mood-stabilizing agents have the highest incidence of severe and life-threatening adverse cutaneous drug reactions (ACDRs). An exanthematous eruption in a patient treated with a mood-stabilizing agent should be viewed as possibly being the initial symptom of...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200304010-00003
更新日期:2003-01-01 00:00:00
abstract::Genital herpes, an incurable viral disease that can have a devastating impact on affected patients, is a serious public health concern affecting one in four Americans. Episodic treatment with nucleoside analogs for 3-5 days is the most common method of treatment; however, since maximum viral replication occurs within ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,随机对照试验,评审
doi:10.2165/00128071-200607040-00001
更新日期:2006-01-01 00:00:00
abstract::Subcutaneous adalimumab (Humira®) is a tumour necrosis factor-α blocker that is the only approved agent for the treatment of moderate to severe hidradenitis suppurativa (HS) in several countries worldwide. This article reviews the clinical efficacy and safety of subcutaneous adalimumab in patients with moderate to sev...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-016-0220-6
更新日期:2016-10-01 00:00:00
abstract::Childhood-onset psoriasis affects approximately one-third of the psoriatic population. Among many potential treatments of childhood psoriasis, biological agents are emerging as a valuable option in the management of this disease. In Europe, etanercept has recently been approved for children aged 8 years and over. Data...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/1153415-S0-000000000-00000
更新日期:2010-01-01 00:00:00