Abstract:
:Granuloma annulare (GA) is a chronic inflammatory disease of unknown etiology characterized by the development of plaques preferentially localized to the distal extremities. Spontaneous remission and relapses are quite common and the course of GA is not easy to predict. Moreover, most therapeutic regimens have been used anecdotally and with variable success. We report the case of a 62-year-old White female patient affected by disseminated GA unsuccessfully treated with psoralen plus UVA photochemotherapy, prednisone, and cyclosporine (ciclosporin) who responded to the anti-tumor necrosis factor-α monoclonal antibody infliximab administered intravenously at a dosage of 5 mg/kg at weeks 0, 2, and 6 and thereafter at monthly intervals for 10 additional months. Most of the GA lesions improved within 8 weeks and then slowly resolved within 10 months of treatment. We suggest that infliximab may be proposed as an additional therapeutic option in the treatment of recalcitrant forms of disseminated GA.
journal_name
Am J Clin Dermatoljournal_title
American journal of clinical dermatologyauthors
Murdaca G,Colombo BM,Barabino G,Caiti M,Cagnati P,Puppo Fdoi
10.2165/11311040-000000000-00000subject
Has Abstractpub_date
2010-12-01 00:00:00pages
437-9issue
6eissn
1175-0561issn
1179-1888journal_volume
11pub_type
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