Abstract：
:As psoriasis and psoriatic arthritis are chronic in nature, ideal treatment should have sustained efficacy, with minimal short- and long-term toxicities to allow lifelong treatment. Traditional therapies used for psoriatic arthritis or psoriasis, including phototherapies and systemic agents, do not satisfy these criteria. Ninety percent of patients surveyed in 1998 by The National Psoriasis Foundation were not satisfied with their treatment options. Several observations have supported the introduction of the tumor necrosis factor (TNF) antagonist etanercept as a treatment for psoriatic disease, including the failure of traditional therapies to meet patient needs, evidence that TNF plays a fundamental role in the inflammatory processes underlying psoriatic arthritis and psoriasis, and the safety and efficacy of this agent in other inflammatory, immune-mediated diseases, such as rheumatoid arthritis (RA). Etanercept prevents initiation of the proinflammatory cascade by competitively binding TNF. First indicated for RA, etanercept is also approved for the treatment of psoriatic arthritis, juvenile RA, ankylosing spondylitis, and most recently psoriasis. Etanercept provides dermatologists with a safe, effective, and convenient treatment option for patients with psoriatic arthritis and psoriasis, which can be used continuously with or without traditional therapies. The self-administered injections provide a distinct advantage over traditional therapies that often require frequent office visits and laboratory monitoring, and other biologic agents that require administration in the doctor's office. Dermatologists should be aware of the ongoing research with etanercept in psoriasis and other dermatologic conditions.
journal_name
Am J Clin Dermatoljournal_title
American journal of clinical dermatologyauthors
Lebwohl MGdoi
10.2165/00128071-200506010-00006subject
Has Abstractpub_date
2005-01-01 00:00:00pages
49-59issue
1eissn
1175-0561issn
1179-1888pii
616journal_volume
6pub_type
杂志文章,评审abstract：BACKGROUND:Efforts have been recently made to investigate simple, objective, accurate, and reproducible methods of clinical/noninvasive assessment of nonsegmental vitiligo. However, studies have mostly considered quantitative or semiquantitative parameters, almost neglecting the purely qualitative appearance of vitilig...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.1007/s40257-012-0001-9
更新日期：2013-02-01 00:00:00
abstract：:In monosymptomatic hypochondriacal psychosis (MHP), such as delusional infestation (DI), the patient has a fixed, false, encapsulated belief associated with tactile hallucinations (TH), most commonly formication, which is defined as cutaneous sensations of crawling, stinging, biting, etc., without evidence of infestat...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-016-0219-z
更新日期：2016-12-01 00:00:00
abstract：:A 46-year-old man developed Stevens-Johnson syndrome and toxic epidermal necrolysis overlap, with severe localized denudation of the skin on the head and neck, following radiotherapy and oral temozolomide therapy for cranial glioblastoma multiforme. He also had a primary malignant fibrous histiocytoma of the thigh tha...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.2165/00128071-200910040-00007
更新日期：2009-01-01 00:00:00
abstract：:Epidermolysis bullosa (EB) represents a group of inherited blistering skin diseases, some forms of which are associated with considerable morbidity and increased mortality. Notably, in recessive dystrophic EB there can be extensive muco-cutaneous fragility and disease complications such as scars, contractures, anemia,...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-013-0059-z
更新日期：2014-02-01 00:00:00
abstract：:Of all the psychotropic medications currently available, the mood-stabilizing agents have the highest incidence of severe and life-threatening adverse cutaneous drug reactions (ACDRs). An exanthematous eruption in a patient treated with a mood-stabilizing agent should be viewed as possibly being the initial symptom of...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200304010-00003
更新日期：2003-01-01 00:00:00
abstract：:Skin disorders are the most common adverse reactions attributed to drugs. Any skin disorder can be imitated, induced or aggravated by drugs. To help you keep up-to-date with the very latest skin reactions occurring with both new and established drugs, this section of the journal brings you information selected from th...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200304070-00007
更新日期：2003-01-01 00:00:00
abstract：:Trigeminal trophic syndrome (TTS) is the historic name for neuropathic self-induced facial ulceration from abnormal sensory symptoms leading to uncontrolled scratching. Anatomic co-localization of sensory loss (numbness) plus neuropathic itch and pain permits painless scratching. If the itch is severe, some patients w...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.2165/11594060-000000000-00000
更新日期：2012-04-01 00:00:00
abstract：:The family of toll-like receptors (TLRs) plays a central role in the cutaneous immune defense system. To date, different TLRs have been found on several major cell populations of the skin, such as keratinocytes, fibroblasts, antigen-presenting cells, and melanocytes. Activation of TLRs leads, via different intracellul...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/11311110-000000000-00000
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Botulinum toxin (BTX) is a potent neurotoxin with a long history of therapeutic application in neurological and dermatological conditions, with a strong efficacy and safety profile. OBJECTIVE:Our aim was to assess whether intradermal injection with BTX-B is an effective treatment for hidradenitis suppurativ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.1007/s40257-020-00537-9
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Videodermatoscopy is a non-invasive technique that allows in vivo skin observation at high magnifications. OBJECTIVE:The goal of this study was to determine if videodermatoscopy enhances diagnostic capability beyond standard clinical observation in three series of patients: one group of patients with overt ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.2165/00128071-200405030-00009
更新日期：2004-01-01 00:00:00
abstract：:Topical retapamulin (Altabax, Altargo) is the first pleuromutilin antibacterial approved for the treatment of uncomplicated superficial skin infections caused by Staphylococcus aureus (excluding methicillin-resistant S. aureus [MRSA]) and Streptococcus pyogenes in patients aged > or = 9 months. In the EU, retapamulin ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.2165/0128071-200809060-00010
更新日期：2008-01-01 00:00:00
abstract：:Black hairy tongue (BHT) is a benign condition commonly found among people who smoke, have poor oral hygiene, are immunocompromised, or have a medical condition limiting their ability to practice good oral hygiene. Though this condition is harmless, patients need to be educated on etiology as many common medications a...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-017-0268-y
更新日期：2017-08-01 00:00:00
abstract：:Hyperhidrosis is a common and distressing condition involving increased production of sweat. A variety of treatment modalities are used to try to control or reduce sweating. Sweat is secreted by eccrine glands innervated by cholinergic fibers from the sympathetic nervous system. Primary hyperhidrosis most commonly aff...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200304100-00003
更新日期：2003-01-01 00:00:00
abstract：:Uncommon types of cutaneous cancers are mainly cited in the literature as case reports and their etiology, pathogenesis and prognosis have to be surmised because of their rarity. Within this group exist the rare and also the unusual, for instance a relatively common carcinoma arising in a strange circumstance. Initial...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200203020-00002
更新日期：2002-01-01 00:00:00
abstract：:A recent study demonstrated an association between psoriasis and dilated cardiomyopathy. Tumour necrosis factor alpha (TNFalpha) may be involved in the pathogenesis of dilated cardiomyopathy and therefore, anti-TNFalpha agents may play a role in the treatment of dilated cardiomyopathy. The case of a 51-year-old woman ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.2165/1153425-S0-000000000-00000
更新日期：2010-01-01 00:00:00
abstract：:We provide a guide for dermatologists to follow if they encounter patients with a rash and clinical history suspicious of Zika virus infection, including diagnostic testing and management options. We also provide an illustrative case report of a patient from Brazil who was diagnosed with Zika virus infection after pre...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-016-0243-z
更新日期：2017-04-01 00:00:00
abstract：:Disorders of cornification are a group of diseases that share abnormalities in the manufacture or desquamation of corneocytes. This paper reviews the major and a few of the rarer ones with a concentration on their therapy. Ichthyosis vulgaris is probably a post-translational defect in pro-filaggrin expression. It show...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200405010-00004
更新日期：2004-01-01 00:00:00
abstract：:Superficial fungal infections are chronic and recurring conditions. Tinea capitis is a scalp infection, primarily affecting prepubescent children. Ringworm infections, such as tinea corporis and tinea cruris, involve the glabrous skin. Tinea nigra is a rare mycotic infection that may be related to travel abroad. Piedr...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200405040-00003
更新日期：2004-01-01 00:00:00
abstract：:Skin disorders are the most common adverse reactions attributed to drugs. Any skin disorder can be imitated, induced or aggravated by drugs. To help you keep up-to-date with the very latest skin reactions occurring with both new and established drugs, this section of the journal brings you information selected from th...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.2165/00128071-200304050-00006
更新日期：2003-01-01 00:00:00
abstract：:Chronic itch is a common skin manifestation in many connective tissue diseases. However, the cause of chronic itch in these diseases is still not fully understood. The complex, and in some cases incomplete understanding of, pathogenesis in each condition makes it difficult to target specific mediators of chronic itch....
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-016-0201-9
更新日期：2016-10-01 00:00:00
abstract：:Darier's disease is a rare cutaneous disease with an autosomal dominant mode of inheritance. Greasy papules and plaques arise on the seborrheic areas and in the flexures and almost all patients have nail abnormalities. Acantholysis and dyskeratosis are the typical histological findings. The underlying defect is a resu...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200304020-00003
更新日期：2003-01-01 00:00:00
abstract：:Pemphigus vulgaris (PV) is a severe chronic autoimmune blistering disease that affects the skin and mucous membranes. It is characterized by suprabasal acantholysis due to disruption of desmosomal connections between keratinocytes. Autoantibodies against desmosomal cadherins, desmoglein 3 and 1, have been shown to ind...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.1007/s40257-020-00544-w
更新日期：2020-12-01 00:00:00
abstract：:Postinflammatory hyperpigmentation (PIH) is a reactive hypermelanosis and sequela of a variety of inflammatory skin conditions. PIH can have a negative impact on a patient's quality of life, particularly for darker-skinned patients. Studies show that dyschromias, including PIH, are one of the most common presenting co...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/11536930-000000000-00000
更新日期：2011-04-01 00:00:00
abstract：:Aging of the skin is associated with skin thinning, atrophy, dryness, wrinkling, and delayed wound healing. These undesirable aging effects are exacerbated by declining estrogen levels in postmenopausal women. With the rise in interest in long-term postmenopausal skin management, studies on the restorative benefits th...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/11589180-000000000-00000
更新日期：2011-10-01 00:00:00
abstract：:In women, acne can be successfully treated with oral contraceptives. This article focuses on the results of clinical studies on the treatment of acne with oral contraceptives. From the literature, 12 such studies could be traced over the last 10 years. Most of the studies were multicenter, randomized, and double blind...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200405060-00008
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:Methotrexate (MTX) is an effective treatment for psoriasis but its use is limited by its toxicity. Folate supplementation can be used to reduce the adverse effects of MTX, though this may impact efficacy. The frequency of folic acid supplementation is not well characterized. PURPOSE:The objective of this st...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-013-0017-9
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND:Many dermatologic disorders are known to adversely affect quality of life (QoL) in close relatives or partners of patients; however, it is unknown whether vitiligo impacts the QoL of family members. OBJECTIVE:The aim of this study was to identify the level and domains in which the QoL of partners/relatives ...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章
doi：10.1007/s40257-013-0037-5
更新日期：2013-12-01 00:00:00
abstract：:Intravenous immunoglobulin (IVIg) has been proposed as a treatment for toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS). A comprehensive search of the literature was conducted to examine the efficacy and safety of IVIg in TEN and SJS patients. Seventeen relevant articles (14 TEN, 3 SJS) were identif...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.2165/00128071-200607060-00004
更新日期：2006-01-01 00:00:00
abstract：:Vulvar lichen sclerosus is an important skin disease that is common in women in their 50 s and beyond; however, it can also affect females of any age, including children. If not treated, it has the potential to cause significant and permanent scarring and deformity of the vulvar structure. In addition, if untreated, i...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-018-0364-7
更新日期：2018-10-01 00:00:00
abstract：:Our ability to successfully treat patients with moderate to severe psoriasis has improved significantly over the last several years with the development of more targeted therapies. IL-17A, a member of the IL-17 family of interleukins, is involved in regulating the innate and adaptive immune systems and has been identi...
journal_title：American journal of clinical dermatology
pub_type： 杂志文章,评审
doi：10.1007/s40257-015-0162-4
更新日期：2016-02-01 00:00:00
