Abstract:
BACKGROUND:Based on the results of numerous preclinical and clinical studies, sertaconazole can be considered a safe and effective drug for the treatment of fungal skin infections. OBJECTIVE:The objective of the study was to compare the efficacy of a solution containing 2% sertaconazole with the well established 2% sertaconazole cream formulation in patients with tinea corporis, tinea pedis interdigitalis, or a corresponding candidosis. METHODS:This was a prospective, open-label, randomized, controlled, parallel-group, multicenter, noninferiority therapy study. Patients received either sertaconazole solution or cream twice daily for 28 days. The full analysis set comprised 160 patients in the solution group and 153 patients in the cream group. The primary efficacy parameter was a combination of culture test result and total clinical score. Efficacy was defined by eradication of the pathogen and reduction of the total clinical score between pretreatment and the final visit. RESULTS:Efficacy was documented in 90.6% of patients using the solution and 88.9% of those using the cream (full analysis set). No adverse events occurred. CONCLUSION:Solution and cream formulations of 2% sertaconazole applied for 28 days were associated with comparable efficacy and safety in the treatment of fungal skin infections.
journal_name
Am J Clin Dermatoljournal_title
American journal of clinical dermatologyauthors
Borelli C,Klövekorn G,Ernst TM,Bödeker RH,Korting HC,Neumeister Cdoi
10.2165/00128071-200708060-00007subject
Has Abstractpub_date
2007-01-01 00:00:00pages
371-8issue
6eissn
1175-0561issn
1179-1888pii
867journal_volume
8pub_type
杂志文章,多中心研究,随机对照试验abstract::Diagnosing acne is easy. However, treatment must be adapted to the type and severity of acne, and must also take into account the impact of acne on patients' quality of life. As there is not always a correlation between the severity of acne and its impact on quality of life, it can be helpful for the dermatologist to ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200607020-00003
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journal_title:American journal of clinical dermatology
pub_type: 杂志文章,随机对照试验
doi:10.2165/00128071-200708050-00003
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pub_type: 杂志文章,meta分析
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journal_title:American journal of clinical dermatology
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