Abstract:
:Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous tumor with a predilection for the head and neck of elderly Caucasian patients. Although much less common than melanoma, MCC has higher rates of sentinel lymph node involvement, local and regional recurrences, and mortality. The majority of MCC cases have been linked to the relatively newly discovered Merkel cell polyomavirus, which is a ubiquitous constituent of the skin flora. Recent discoveries regarding viral integration and carcinogenesis and the immunologic features of MCC have expanded the understanding of MCC. These discoveries have led to the development and application of emerging therapies such as somatostatin analogs, immune checkpoint inhibition, adoptive cell therapy, and other exciting possibilities for targeted therapy.
journal_name
Am J Clin Dermatoljournal_title
American journal of clinical dermatologyauthors
Brummer GC,Bowen AR,Bowen GMdoi
10.1007/s40257-015-0163-3subject
Has Abstractpub_date
2016-02-01 00:00:00pages
49-62issue
1eissn
1175-0561issn
1179-1888pii
10.1007/s40257-015-0163-3journal_volume
17pub_type
杂志文章,评审abstract::Chronic venous insufficiency (CVI) occurs in a relatively large proportion of the population and is associated with significant morbidity, high cost of healthcare, loss of productivity and reduced quality of life. Lower extremity ulcers related to CVI have been estimated to affect 0.2-1% of the population in developed...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200304080-00007
更新日期:2003-01-01 00:00:00
abstract::The treatment of cutaneous T cell lymphoma (CTCL), which includes mycosis fungoides and Sezary syndrome, has been in a state of continual change over recent decades, as new therapies are constantly emerging in the search for more effective treatments for the disease. However, prognosis and survival of patients with CT...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200203030-00006
更新日期:2002-01-01 00:00:00
abstract:UNLABELLED:Topical application of the antibacterial agent metronidazole is effective in the treatment of moderate to severe rosacea, although its mechanism of action has yet to be clearly established. Metronidazole preparations (0.75 and 1% cream, 0.75% gel and 0.75% lotion) were significantly more effective than place...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200001030-00007
更新日期:2000-05-01 00:00:00
abstract::Itch, also known as pruritus, is the major symptom in skin diseases with a variety of etiologies and pathophysiologies. Significant progress has been achieved in understanding the pathophysiology of itch in the last 5 years. Neurophysiological experiments in humans and animals have revealed that itch is carried by spe...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200304090-00004
更新日期:2003-01-01 00:00:00
abstract::Hyperhidrosis is a common and distressing condition involving increased production of sweat. A variety of treatment modalities are used to try to control or reduce sweating. Sweat is secreted by eccrine glands innervated by cholinergic fibers from the sympathetic nervous system. Primary hyperhidrosis most commonly aff...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200304100-00003
更新日期:2003-01-01 00:00:00
abstract::Systemic sclerosis is an extremely variable disease in its manifestations and consequently, treatment needs to be individualized depending on the specific problems that each patient has. Limited scleroderma patients have a prolonged duration of Raynaud's phenomenon and puffy fingers before they develop any skin thicke...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200102050-00006
更新日期:2001-01-01 00:00:00
abstract::Genital herpes, an incurable viral disease that can have a devastating impact on affected patients, is a serious public health concern affecting one in four Americans. Episodic treatment with nucleoside analogs for 3-5 days is the most common method of treatment; however, since maximum viral replication occurs within ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,随机对照试验,评审
doi:10.2165/00128071-200607040-00001
更新日期:2006-01-01 00:00:00
abstract::Of all the psychotropic medications currently available, the mood-stabilizing agents have the highest incidence of severe and life-threatening adverse cutaneous drug reactions (ACDRs). An exanthematous eruption in a patient treated with a mood-stabilizing agent should be viewed as possibly being the initial symptom of...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200304010-00003
更新日期:2003-01-01 00:00:00
abstract::Most people in modern society are exposed daily to fragrance ingredients from one or more sources. Fragrance ingredients are also one of the most frequent causes of contact allergic reactions. The diagnosis is made by patch testing with a mixture of fragrance ingredients, the fragrance mix. This gives a positive patch...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200304110-00006
更新日期:2003-01-01 00:00:00
abstract::Recent advances in our understanding of the pathophysiology of atopic dermatitis (AD) have revealed that skin microbiome dysbiosis plays an important role in the disease. In this review, we describe how changes in the structure and function of the microbiome are involved in the pathogenesis of AD. We highlight recent ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-020-00538-8
更新日期:2020-09-01 00:00:00
abstract::Photodynamic therapy (PDT) is proposed as an effective therapy with a good safety profile for patients with actinic keratoses. PDT involves the application of a photosensitizer to dysplastic or neoplastic tissue such that when exposed to light of an appropriate wavelength, the target tissue undergoes a cytotoxic react...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200304030-00001
更新日期:2003-01-01 00:00:00
abstract::A 46-year-old man developed Stevens-Johnson syndrome and toxic epidermal necrolysis overlap, with severe localized denudation of the skin on the head and neck, following radiotherapy and oral temozolomide therapy for cranial glioblastoma multiforme. He also had a primary malignant fibrous histiocytoma of the thigh tha...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/00128071-200910040-00007
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Many dermatologic disorders are known to adversely affect quality of life (QoL) in close relatives or partners of patients; however, it is unknown whether vitiligo impacts the QoL of family members. OBJECTIVE:The aim of this study was to identify the level and domains in which the QoL of partners/relatives ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.1007/s40257-013-0037-5
更新日期:2013-12-01 00:00:00
abstract::Cutaneous reactions to tattoos are not uncommon and various histologic patterns have been reported, including lichenoid, granulomatous, eczematous, and pseudolymphomatous reactions. Such patterns may develop with highly variable delay after the tattooing procedure. We report three strikingly similar cases of a fast-oc...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/00128071-200809050-00009
更新日期:2008-01-01 00:00:00
abstract::Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that may be caused by an adverse drug reaction. We discuss the clinical presentation and outcomes of 52 cases of drug-induced PG reported to date in the literature. We conducted our literature search for case reports of drug-induced PG using keywords on PubMe...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-017-0308-7
更新日期:2018-02-01 00:00:00
abstract::There is a high unmet clinical need for new and better treatments in acne vulgaris. Propionibacterium acnes has a strong proinflammatory activity and targets molecules involved in the innate cutaneous immunity, keratinocytes and sebaceous glands of the pilosebaceous follicle. The role of P. acnes in acne confers legit...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.1007/s40257-013-0042-8
更新日期:2013-12-01 00:00:00
abstract::Occupational contact dermatitis (OCD) represents 90 to 95% of all occupational dermatoses. The incidence rate of OCD is estimated to be around 0.5 to 1.9 cases per full-time worker per year. However, epidemiologic data are lacking and incidence is probably underestimated, especially in the US. Over the past 20 years, ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200102060-00002
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Dementia is a syndrome that involves the deterioration of several higher mental functions in advanced age, and psoriasis is an autoimmune disease characterized by skin plaque. Epidemiological studies have indicated an association between dementia and psoriasis; however, to date, no studies in Asia have repor...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.1007/s40257-018-00420-8
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:5% topical minoxidil solution has been widely used to stimulate new hair growth and help stop hair loss in men with androgenetic alopecia (AGA). However, it is not convenient for patients to continue applying the solution twice daily on a regular basis. Tretinoin is known to increase the percutaneous absorpt...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,随机对照试验
doi:10.2165/00128071-200708050-00003
更新日期:2007-01-01 00:00:00
abstract::Superficial fungal infections are chronic and recurring conditions. Tinea capitis is a scalp infection, primarily affecting prepubescent children. Ringworm infections, such as tinea corporis and tinea cruris, involve the glabrous skin. Tinea nigra is a rare mycotic infection that may be related to travel abroad. Piedr...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200405040-00003
更新日期:2004-01-01 00:00:00
abstract::Erythema annulare centrifugum is a reactive erythema of various possible etiologies including, although less often, an associated cancer. Cancer-related erythema annulare centrifugum is most commonly associated with lymphoproliferative malignancies, specifically lymphoma and leukemia. Malignancy-associated erythema an...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/11596580-000000000-00000
更新日期:2012-08-01 00:00:00
abstract::Acne vulgaris is one of the most common inflammatory dermatoses and is seen in both the hospital setting and in general practice. Multiple factors are involved in the pathophysiology of acne, including: an alteration in the pattern of keratinization within the pilosebaceous follicles resulting in comedone formation; a...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200102030-00002
更新日期:2001-01-01 00:00:00
abstract::Keratosis follicularis spinulosa decalvans is a rare, X-linked disorder characterized by scarring alopecia of the scalp and eyebrows in the setting of widespread keratosis pilaris. Less frequent associations are ocular abnormalities and palmoplantar keratoderma. Acne keloidalis nuchae has previously been described in ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/00128071-200809020-00009
更新日期:2008-01-01 00:00:00
abstract::Spinosad 0.9% suspension is a topical treatment for head-lice infestation (pediculosis capitis) that has been approved in the US as a prescription medicine. Spinosad is a natural mixture of the pediculicidal tetracyclic macrolides spinosyn A and spinosyn D. Spinosad 0.9% mainly interferes with nicotinic acetylcholine ...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/11208070-000000000-00000
更新日期:2011-10-01 00:00:00
abstract::Intravenous immunoglobulin (IVIg) has been proposed as a treatment for toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS). A comprehensive search of the literature was conducted to examine the efficacy and safety of IVIg in TEN and SJS patients. Seventeen relevant articles (14 TEN, 3 SJS) were identif...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200607060-00004
更新日期:2006-01-01 00:00:00
abstract::As psoriasis and psoriatic arthritis are chronic in nature, ideal treatment should have sustained efficacy, with minimal short- and long-term toxicities to allow lifelong treatment. Traditional therapies used for psoriatic arthritis or psoriasis, including phototherapies and systemic agents, do not satisfy these crite...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200506010-00006
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:A meta-analysis of 3 major German studies conducted between 1989 and 1994 with cyclosporine in severe psoriasis was performed to allow an integrated evaluation of the efficacy and tolerability of cyclosporine in this indication. DESIGN AND SETTING:All 3 studies were prospective, randomized, parallel group st...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,meta分析
doi:10.2165/00128071-200102010-00007
更新日期:2001-01-01 00:00:00
abstract::The connection between the brain and the skin is more than a physiologic fact. Skin conditions can impose great effects on every field in the patients' lives. Reciprocally, skin diseases can be evoked by psychological problems. A psychodermatology clinic is the format that enables dermatology patients to receive a com...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.2165/11630950-000000000-00000
更新日期:2012-04-01 00:00:00
abstract::Pemphigus vulgaris (PV) is a severe chronic autoimmune blistering disease that affects the skin and mucous membranes. It is characterized by suprabasal acantholysis due to disruption of desmosomal connections between keratinocytes. Autoantibodies against desmosomal cadherins, desmoglein 3 and 1, have been shown to ind...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章
doi:10.1007/s40257-020-00544-w
更新日期:2020-12-01 00:00:00
abstract::In women, acne can be successfully treated with oral contraceptives. This article focuses on the results of clinical studies on the treatment of acne with oral contraceptives. From the literature, 12 such studies could be traced over the last 10 years. Most of the studies were multicenter, randomized, and double blind...
journal_title:American journal of clinical dermatology
pub_type: 杂志文章,评审
doi:10.2165/00128071-200405060-00008
更新日期:2004-01-01 00:00:00