Merkel Cell Carcinoma: Current Issues Regarding Diagnosis, Management, and Emerging Treatment Strategies.

Abstract:

:Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous tumor with a predilection for the head and neck of elderly Caucasian patients. Although much less common than melanoma, MCC has higher rates of sentinel lymph node involvement, local and regional recurrences, and mortality. The majority of MCC cases have been linked to the relatively newly discovered Merkel cell polyomavirus, which is a ubiquitous constituent of the skin flora. Recent discoveries regarding viral integration and carcinogenesis and the immunologic features of MCC have expanded the understanding of MCC. These discoveries have led to the development and application of emerging therapies such as somatostatin analogs, immune checkpoint inhibition, adoptive cell therapy, and other exciting possibilities for targeted therapy.

journal_name

Am J Clin Dermatol

authors

Brummer GC,Bowen AR,Bowen GM

doi

10.1007/s40257-015-0163-3

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

49-62

issue

1

eissn

1175-0561

issn

1179-1888

pii

10.1007/s40257-015-0163-3

journal_volume

17

pub_type

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